Synovial fluid macrophages are capable of osteoclast formation and resorption

To determine whether synovial fluid (SF) macrophages isolated from the SF of osteoarthritis (OA), rheumatoid arthritis (RA) and pyrophosphate arthropathy (PPA) joints are capable of osteoclast formation, and to investigate the cellular and humoral factors required for this to occur, SF macrophages (...

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Veröffentlicht in:The Journal of pathology 2006-01, Vol.208 (1), p.35-43
Hauptverfasser: Adamopoulos, IE, Sabokbar, A, Wordsworth, BP, Carr, A, Ferguson, DJ, Athanasou, NA
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container_title The Journal of pathology
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creator Adamopoulos, IE
Sabokbar, A
Wordsworth, BP
Carr, A
Ferguson, DJ
Athanasou, NA
description To determine whether synovial fluid (SF) macrophages isolated from the SF of osteoarthritis (OA), rheumatoid arthritis (RA) and pyrophosphate arthropathy (PPA) joints are capable of osteoclast formation, and to investigate the cellular and humoral factors required for this to occur, SF macrophages (CD14+) were isolated from the knee joint SF from patients with OA, RA and PPA and cultured for up to 14 days with macrophage‐colony stimulating factor (M‐CSF) and soluble receptor activator for nuclear factor‐κB ligand (RANKL) or tumour‐necrosis factor‐α (TNFα) and interleukin‐1α (IL‐1α). Osteoclast differentiation was assessed by expression of tartrate‐resistant acid phosphatase (TRAP) and vitronectin receptor (VNR), F‐actin ring formation and lacunar resorption. Osteoclast formation and lacunar resorption was seen in RANKL‐treated cultures of SF macrophages isolated from OA, RA and PPA joints with the largest amount of resorption noted in RA and PPA SF macrophage cultures. In TNFα/IL‐1α‐treated RA and PPA SF macrophage cultures, osteoclasts capable of lacunar resorption were also formed. Lacunar resorption was more extensive in RANKL than TNFα/IL‐1α‐treated cultures. These findings indicate that SF macrophages are capable of differentiating into mature osteoclasts capable of lacunar resorption. M‐CSF in combination with RANKL or TNFα/IL‐1α was required for osteoclast formation. As inflammatory synovial fluids contain an increase in the number of macrophages and an increase in the amounts of RANKL, TNFα and IL‐1α, these findings suggest that one means whereby bone erosions may form in rheumatoid or crystal arthritis is by differentiation of synovial fluid macrophages into osteoclasts. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
doi_str_mv 10.1002/path.1891
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Osteoclast differentiation was assessed by expression of tartrate‐resistant acid phosphatase (TRAP) and vitronectin receptor (VNR), F‐actin ring formation and lacunar resorption. Osteoclast formation and lacunar resorption was seen in RANKL‐treated cultures of SF macrophages isolated from OA, RA and PPA joints with the largest amount of resorption noted in RA and PPA SF macrophage cultures. In TNFα/IL‐1α‐treated RA and PPA SF macrophage cultures, osteoclasts capable of lacunar resorption were also formed. Lacunar resorption was more extensive in RANKL than TNFα/IL‐1α‐treated cultures. These findings indicate that SF macrophages are capable of differentiating into mature osteoclasts capable of lacunar resorption. M‐CSF in combination with RANKL or TNFα/IL‐1α was required for osteoclast formation. As inflammatory synovial fluids contain an increase in the number of macrophages and an increase in the amounts of RANKL, TNFα and IL‐1α, these findings suggest that one means whereby bone erosions may form in rheumatoid or crystal arthritis is by differentiation of synovial fluid macrophages into osteoclasts. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.1891</identifier><identifier>PMID: 16278818</identifier><identifier>CODEN: JPTLAS</identifier><language>eng</language><publisher>Chichester, UK: John Wiley &amp; Sons, Ltd</publisher><subject>Aged ; Arthritis, Rheumatoid - immunology ; Arthritis, Rheumatoid - physiopathology ; Biological and medical sciences ; Bone Resorption - immunology ; Bone Resorption - physiopathology ; Carrier Proteins - immunology ; Carrier Proteins - physiology ; Cell Differentiation - immunology ; Cell Differentiation - physiology ; Cells, Cultured ; Chondrocalcinosis - immunology ; Chondrocalcinosis - physiopathology ; Diseases of the osteoarticular system ; Female ; Humans ; Interleukin-1 - immunology ; Interleukin-1 - physiology ; Investigative techniques, diagnostic techniques (general aspects) ; Knee Joint - immunology ; Knee Joint - physiopathology ; Lipopolysaccharide Receptors - immunology ; macrophages ; Macrophages - immunology ; Macrophages - physiology ; Male ; Medical sciences ; Membrane Glycoproteins - immunology ; Membrane Glycoproteins - physiology ; Middle Aged ; Osteoarthritis ; Osteoarthritis, Knee - immunology ; Osteoarthritis, Knee - physiopathology ; osteoclasts ; Osteoclasts - immunology ; Osteoclasts - physiology ; Osteogenesis - immunology ; Osteogenesis - physiology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Phenotype ; pyrophosphate ; RANK Ligand ; Receptor Activator of Nuclear Factor-kappa B ; rheumatoid arthritis ; synovial fluid ; Synovial Fluid - immunology ; Synovial Fluid - physiology ; Tumor Necrosis Factor-alpha - immunology ; Tumor Necrosis Factor-alpha - physiology</subject><ispartof>The Journal of pathology, 2006-01, Vol.208 (1), p.35-43</ispartof><rights>Copyright © 2005 Pathological Society of Great Britain and Ireland. 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Pathol</addtitle><description>To determine whether synovial fluid (SF) macrophages isolated from the SF of osteoarthritis (OA), rheumatoid arthritis (RA) and pyrophosphate arthropathy (PPA) joints are capable of osteoclast formation, and to investigate the cellular and humoral factors required for this to occur, SF macrophages (CD14+) were isolated from the knee joint SF from patients with OA, RA and PPA and cultured for up to 14 days with macrophage‐colony stimulating factor (M‐CSF) and soluble receptor activator for nuclear factor‐κB ligand (RANKL) or tumour‐necrosis factor‐α (TNFα) and interleukin‐1α (IL‐1α). Osteoclast differentiation was assessed by expression of tartrate‐resistant acid phosphatase (TRAP) and vitronectin receptor (VNR), F‐actin ring formation and lacunar resorption. 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Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Phenotype</subject><subject>pyrophosphate</subject><subject>RANK Ligand</subject><subject>Receptor Activator of Nuclear Factor-kappa B</subject><subject>rheumatoid arthritis</subject><subject>synovial fluid</subject><subject>Synovial Fluid - immunology</subject><subject>Synovial Fluid - physiology</subject><subject>Tumor Necrosis Factor-alpha - immunology</subject><subject>Tumor Necrosis Factor-alpha - physiology</subject><issn>0022-3417</issn><issn>1096-9896</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EosvCgT-AcgGJQ1p_xLF9rCpokbYFRCkSF2vs2DTgxKmdBfbf49VG9IQ4zYzmeWc07yD0nOBjgjE9mWC-PSZSkQdoRbBqayVV-xCtSo_WrCHiCD3J-TvGWCnOH6Mj0lIhJZErdPlpN8afPYTKh23fVQPYFKdb-OZyBclVFiYwwVXRVzHPLtoAea58TAPMfRwrGLsquRzTtC-fokceQnbPlrhGn9--uT67qDfvz9-dnW5q21BKatMaxUwDpusMMM9dSRihYCnmyptWccq8dQybrrFWNIoR3jlshGeS0iJZo1eHuVOKd1uXZz302boQYHRxm7XAREkh5H9BIhqBOccFfH0Ay_k5J-f1lPoB0k4TrPcm673Jem9yYV8sQ7dmcN09ubhagJcLANlC8AlG2-d7TjAmWblxjU4O3K8-uN2_N-oPp9cXy-r6oOjLM37_VUD6oVvBBNdfrs711UfW3Nx8vdQb9gc-4KRt</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Adamopoulos, IE</creator><creator>Sabokbar, A</creator><creator>Wordsworth, BP</creator><creator>Carr, A</creator><creator>Ferguson, DJ</creator><creator>Athanasou, NA</creator><general>John Wiley &amp; Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>Synovial fluid macrophages are capable of osteoclast formation and resorption</title><author>Adamopoulos, IE ; Sabokbar, A ; Wordsworth, BP ; Carr, A ; Ferguson, DJ ; Athanasou, NA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4221-b6b93b4abddba3f5ebdd312ac2059fb69523fce30bd4cc749315de0b7f3822ba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Arthritis, Rheumatoid - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Bone Resorption - immunology</topic><topic>Bone Resorption - physiopathology</topic><topic>Carrier Proteins - immunology</topic><topic>Carrier Proteins - physiology</topic><topic>Cell Differentiation - immunology</topic><topic>Cell Differentiation - physiology</topic><topic>Cells, Cultured</topic><topic>Chondrocalcinosis - immunology</topic><topic>Chondrocalcinosis - physiopathology</topic><topic>Diseases of the osteoarticular system</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-1 - immunology</topic><topic>Interleukin-1 - physiology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Knee Joint - immunology</topic><topic>Knee Joint - physiopathology</topic><topic>Lipopolysaccharide Receptors - immunology</topic><topic>macrophages</topic><topic>Macrophages - immunology</topic><topic>Macrophages - physiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - immunology</topic><topic>Membrane Glycoproteins - physiology</topic><topic>Middle Aged</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Knee - immunology</topic><topic>Osteoarthritis, Knee - physiopathology</topic><topic>osteoclasts</topic><topic>Osteoclasts - immunology</topic><topic>Osteoclasts - physiology</topic><topic>Osteogenesis - immunology</topic><topic>Osteogenesis - physiology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Phenotype</topic><topic>pyrophosphate</topic><topic>RANK Ligand</topic><topic>Receptor Activator of Nuclear Factor-kappa B</topic><topic>rheumatoid arthritis</topic><topic>synovial fluid</topic><topic>Synovial Fluid - immunology</topic><topic>Synovial Fluid - physiology</topic><topic>Tumor Necrosis Factor-alpha - immunology</topic><topic>Tumor Necrosis Factor-alpha - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adamopoulos, IE</creatorcontrib><creatorcontrib>Sabokbar, A</creatorcontrib><creatorcontrib>Wordsworth, BP</creatorcontrib><creatorcontrib>Carr, A</creatorcontrib><creatorcontrib>Ferguson, DJ</creatorcontrib><creatorcontrib>Athanasou, NA</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adamopoulos, IE</au><au>Sabokbar, A</au><au>Wordsworth, BP</au><au>Carr, A</au><au>Ferguson, DJ</au><au>Athanasou, NA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synovial fluid macrophages are capable of osteoclast formation and resorption</atitle><jtitle>The Journal of pathology</jtitle><addtitle>J. Pathol</addtitle><date>2006-01</date><risdate>2006</risdate><volume>208</volume><issue>1</issue><spage>35</spage><epage>43</epage><pages>35-43</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><coden>JPTLAS</coden><abstract>To determine whether synovial fluid (SF) macrophages isolated from the SF of osteoarthritis (OA), rheumatoid arthritis (RA) and pyrophosphate arthropathy (PPA) joints are capable of osteoclast formation, and to investigate the cellular and humoral factors required for this to occur, SF macrophages (CD14+) were isolated from the knee joint SF from patients with OA, RA and PPA and cultured for up to 14 days with macrophage‐colony stimulating factor (M‐CSF) and soluble receptor activator for nuclear factor‐κB ligand (RANKL) or tumour‐necrosis factor‐α (TNFα) and interleukin‐1α (IL‐1α). Osteoclast differentiation was assessed by expression of tartrate‐resistant acid phosphatase (TRAP) and vitronectin receptor (VNR), F‐actin ring formation and lacunar resorption. Osteoclast formation and lacunar resorption was seen in RANKL‐treated cultures of SF macrophages isolated from OA, RA and PPA joints with the largest amount of resorption noted in RA and PPA SF macrophage cultures. In TNFα/IL‐1α‐treated RA and PPA SF macrophage cultures, osteoclasts capable of lacunar resorption were also formed. Lacunar resorption was more extensive in RANKL than TNFα/IL‐1α‐treated cultures. These findings indicate that SF macrophages are capable of differentiating into mature osteoclasts capable of lacunar resorption. M‐CSF in combination with RANKL or TNFα/IL‐1α was required for osteoclast formation. As inflammatory synovial fluids contain an increase in the number of macrophages and an increase in the amounts of RANKL, TNFα and IL‐1α, these findings suggest that one means whereby bone erosions may form in rheumatoid or crystal arthritis is by differentiation of synovial fluid macrophages into osteoclasts. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley &amp; Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley &amp; Sons, Ltd</pub><pmid>16278818</pmid><doi>10.1002/path.1891</doi><tpages>9</tpages></addata></record>
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subjects Aged
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - physiopathology
Biological and medical sciences
Bone Resorption - immunology
Bone Resorption - physiopathology
Carrier Proteins - immunology
Carrier Proteins - physiology
Cell Differentiation - immunology
Cell Differentiation - physiology
Cells, Cultured
Chondrocalcinosis - immunology
Chondrocalcinosis - physiopathology
Diseases of the osteoarticular system
Female
Humans
Interleukin-1 - immunology
Interleukin-1 - physiology
Investigative techniques, diagnostic techniques (general aspects)
Knee Joint - immunology
Knee Joint - physiopathology
Lipopolysaccharide Receptors - immunology
macrophages
Macrophages - immunology
Macrophages - physiology
Male
Medical sciences
Membrane Glycoproteins - immunology
Membrane Glycoproteins - physiology
Middle Aged
Osteoarthritis
Osteoarthritis, Knee - immunology
Osteoarthritis, Knee - physiopathology
osteoclasts
Osteoclasts - immunology
Osteoclasts - physiology
Osteogenesis - immunology
Osteogenesis - physiology
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Phenotype
pyrophosphate
RANK Ligand
Receptor Activator of Nuclear Factor-kappa B
rheumatoid arthritis
synovial fluid
Synovial Fluid - immunology
Synovial Fluid - physiology
Tumor Necrosis Factor-alpha - immunology
Tumor Necrosis Factor-alpha - physiology
title Synovial fluid macrophages are capable of osteoclast formation and resorption
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