The NKG2D receptor: immunobiology and clinical implications
NK cells are critical components of our immune system functioning, in part, to recognize and then eradicate virally infected or tumorigenic cells without previous sensitization. One of the best-characterized activating receptors expressed on NK cells is the NKG2D receptor, which is capable of transm...
Gespeichert in:
| Veröffentlicht in: | Immunologic research 2008-01, Vol.40 (1), p.18-34 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 34 |
|---|---|
| container_issue | 1 |
| container_start_page | 18 |
| container_title | Immunologic research |
| container_volume | 40 |
| creator | Burgess, Steven J. Maasho, Kerima Masilamani, Madhan Narayanan, Sriram Borrego, Francisco Coligan, John E. |
| description | NK cells are critical components of our immune system functioning, in part, to recognize and then eradicate virally infected or tumorigenic cells without previous sensitization. One of the best-characterized activating receptors expressed on NK cells is the NKG2D receptor, which is capable of transmitting co-stimulatory signals by subsets of T cells. Viruses and tumors have evolved strategies to evade NKG2D-mediated immune recognition thus highlighting the importance of this receptor in immunity. This review will focus on the structure of NKG2D and its interaction with its diverse array of ligands, as well as highlighting current knowledge regarding NKG2D signal transduction and biological mechanisms that govern its cell surface expression. The impact that NKG2D has in disease pathologies is also assessed. |
| doi_str_mv | 10.1007/s12026-007-0060-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70198673</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1897192491</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-113288da6505cb77cc15c8e8a685c001aa57a4b4a47420a6a5a6bf889d794f803</originalsourceid><addsrcrecordid>eNqFkM9LwzAUx4Mobk7_AC9SPHirJml-6kmmTnHoZYK3kKbp7GibmqyH_fdmdKAI4uHxvvA-7_uSLwCnCF4iCPlVQBhilkYZi8FU7oExolSmkFO6D8YQU55izt9H4CiEFYSIEZIdghESSGYZQ2Nws_iwycvzDN8l3hrbrZ2_Tqqm6VuXV652y02i2yIxddVWRtdx1NVRrCvXhmNwUOo62JNdn4C3h_vF9DGdv86eprfz1BDG1ilCGRai0IxCanLOjUHUCCs0E9TEN2lNuSY50YQTDDXTVLO8FEIWXJJSwGwCLgbfzrvP3oa1aqpgbF3r1ro-KA6RFIxn_4IYCiohQRE8_wWuXO_b-AmFZEQyKmWE0AAZ70LwtlSdrxrtNwpBtc1fDfmrrdzmr7Y7ZzvjPm9s8b2xCzwCeABCHLVL639c_tP1C7Cgjcg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>195903599</pqid></control><display><type>article</type><title>The NKG2D receptor: immunobiology and clinical implications</title><source>MEDLINE</source><source>Springer Nature</source><creator>Burgess, Steven J. ; Maasho, Kerima ; Masilamani, Madhan ; Narayanan, Sriram ; Borrego, Francisco ; Coligan, John E.</creator><creatorcontrib>Burgess, Steven J. ; Maasho, Kerima ; Masilamani, Madhan ; Narayanan, Sriram ; Borrego, Francisco ; Coligan, John E.</creatorcontrib><description>NK cells are critical components of our immune system functioning, in part, to recognize and then eradicate virally infected or tumorigenic cells without previous sensitization. One of the best-characterized activating receptors expressed on NK cells is the NKG2D receptor, which is capable of transmitting co-stimulatory signals by subsets of T cells. Viruses and tumors have evolved strategies to evade NKG2D-mediated immune recognition thus highlighting the importance of this receptor in immunity. This review will focus on the structure of NKG2D and its interaction with its diverse array of ligands, as well as highlighting current knowledge regarding NKG2D signal transduction and biological mechanisms that govern its cell surface expression. The impact that NKG2D has in disease pathologies is also assessed.</description><identifier>ISSN: 0257-277X</identifier><identifier>EISSN: 1559-0755</identifier><identifier>DOI: 10.1007/s12026-007-0060-9</identifier><identifier>PMID: 18193361</identifier><language>eng</language><publisher>New York: Humana Press Inc</publisher><subject>Allergology ; Animals ; Autoimmunity - immunology ; Biomedical and Life Sciences ; Biomedicine ; Cells ; Communicable Diseases - immunology ; Humans ; Immunology ; Internal Medicine ; Killer Cells, Natural - immunology ; Killer Cells, Natural - metabolism ; Ligands ; Medicine/Public Health ; Neoplasms - immunology ; NK Cell Lectin-Like Receptor Subfamily K ; Receptors, Immunologic - metabolism ; Receptors, Immunologic - physiology ; Receptors, Natural Killer Cell ; Signal Transduction - immunology ; Studies</subject><ispartof>Immunologic research, 2008-01, Vol.40 (1), p.18-34</ispartof><rights>Humana Press Inc. 2007</rights><rights>Humana Press 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-113288da6505cb77cc15c8e8a685c001aa57a4b4a47420a6a5a6bf889d794f803</citedby><cites>FETCH-LOGICAL-c466t-113288da6505cb77cc15c8e8a685c001aa57a4b4a47420a6a5a6bf889d794f803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12026-007-0060-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12026-007-0060-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18193361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Burgess, Steven J.</creatorcontrib><creatorcontrib>Maasho, Kerima</creatorcontrib><creatorcontrib>Masilamani, Madhan</creatorcontrib><creatorcontrib>Narayanan, Sriram</creatorcontrib><creatorcontrib>Borrego, Francisco</creatorcontrib><creatorcontrib>Coligan, John E.</creatorcontrib><title>The NKG2D receptor: immunobiology and clinical implications</title><title>Immunologic research</title><addtitle>Immunol Res</addtitle><addtitle>Immunol Res</addtitle><description>NK cells are critical components of our immune system functioning, in part, to recognize and then eradicate virally infected or tumorigenic cells without previous sensitization. One of the best-characterized activating receptors expressed on NK cells is the NKG2D receptor, which is capable of transmitting co-stimulatory signals by subsets of T cells. Viruses and tumors have evolved strategies to evade NKG2D-mediated immune recognition thus highlighting the importance of this receptor in immunity. This review will focus on the structure of NKG2D and its interaction with its diverse array of ligands, as well as highlighting current knowledge regarding NKG2D signal transduction and biological mechanisms that govern its cell surface expression. The impact that NKG2D has in disease pathologies is also assessed.</description><subject>Allergology</subject><subject>Animals</subject><subject>Autoimmunity - immunology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cells</subject><subject>Communicable Diseases - immunology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Internal Medicine</subject><subject>Killer Cells, Natural - immunology</subject><subject>Killer Cells, Natural - metabolism</subject><subject>Ligands</subject><subject>Medicine/Public Health</subject><subject>Neoplasms - immunology</subject><subject>NK Cell Lectin-Like Receptor Subfamily K</subject><subject>Receptors, Immunologic - metabolism</subject><subject>Receptors, Immunologic - physiology</subject><subject>Receptors, Natural Killer Cell</subject><subject>Signal Transduction - immunology</subject><subject>Studies</subject><issn>0257-277X</issn><issn>1559-0755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkM9LwzAUx4Mobk7_AC9SPHirJml-6kmmTnHoZYK3kKbp7GibmqyH_fdmdKAI4uHxvvA-7_uSLwCnCF4iCPlVQBhilkYZi8FU7oExolSmkFO6D8YQU55izt9H4CiEFYSIEZIdghESSGYZQ2Nws_iwycvzDN8l3hrbrZ2_Tqqm6VuXV652y02i2yIxddVWRtdx1NVRrCvXhmNwUOo62JNdn4C3h_vF9DGdv86eprfz1BDG1ilCGRai0IxCanLOjUHUCCs0E9TEN2lNuSY50YQTDDXTVLO8FEIWXJJSwGwCLgbfzrvP3oa1aqpgbF3r1ro-KA6RFIxn_4IYCiohQRE8_wWuXO_b-AmFZEQyKmWE0AAZ70LwtlSdrxrtNwpBtc1fDfmrrdzmr7Y7ZzvjPm9s8b2xCzwCeABCHLVL639c_tP1C7Cgjcg</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Burgess, Steven J.</creator><creator>Maasho, Kerima</creator><creator>Masilamani, Madhan</creator><creator>Narayanan, Sriram</creator><creator>Borrego, Francisco</creator><creator>Coligan, John E.</creator><general>Humana Press Inc</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>The NKG2D receptor: immunobiology and clinical implications</title><author>Burgess, Steven J. ; Maasho, Kerima ; Masilamani, Madhan ; Narayanan, Sriram ; Borrego, Francisco ; Coligan, John E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-113288da6505cb77cc15c8e8a685c001aa57a4b4a47420a6a5a6bf889d794f803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Allergology</topic><topic>Animals</topic><topic>Autoimmunity - immunology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cells</topic><topic>Communicable Diseases - immunology</topic><topic>Humans</topic><topic>Immunology</topic><topic>Internal Medicine</topic><topic>Killer Cells, Natural - immunology</topic><topic>Killer Cells, Natural - metabolism</topic><topic>Ligands</topic><topic>Medicine/Public Health</topic><topic>Neoplasms - immunology</topic><topic>NK Cell Lectin-Like Receptor Subfamily K</topic><topic>Receptors, Immunologic - metabolism</topic><topic>Receptors, Immunologic - physiology</topic><topic>Receptors, Natural Killer Cell</topic><topic>Signal Transduction - immunology</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burgess, Steven J.</creatorcontrib><creatorcontrib>Maasho, Kerima</creatorcontrib><creatorcontrib>Masilamani, Madhan</creatorcontrib><creatorcontrib>Narayanan, Sriram</creatorcontrib><creatorcontrib>Borrego, Francisco</creatorcontrib><creatorcontrib>Coligan, John E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Immunologic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burgess, Steven J.</au><au>Maasho, Kerima</au><au>Masilamani, Madhan</au><au>Narayanan, Sriram</au><au>Borrego, Francisco</au><au>Coligan, John E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The NKG2D receptor: immunobiology and clinical implications</atitle><jtitle>Immunologic research</jtitle><stitle>Immunol Res</stitle><addtitle>Immunol Res</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>40</volume><issue>1</issue><spage>18</spage><epage>34</epage><pages>18-34</pages><issn>0257-277X</issn><eissn>1559-0755</eissn><abstract>NK cells are critical components of our immune system functioning, in part, to recognize and then eradicate virally infected or tumorigenic cells without previous sensitization. One of the best-characterized activating receptors expressed on NK cells is the NKG2D receptor, which is capable of transmitting co-stimulatory signals by subsets of T cells. Viruses and tumors have evolved strategies to evade NKG2D-mediated immune recognition thus highlighting the importance of this receptor in immunity. This review will focus on the structure of NKG2D and its interaction with its diverse array of ligands, as well as highlighting current knowledge regarding NKG2D signal transduction and biological mechanisms that govern its cell surface expression. The impact that NKG2D has in disease pathologies is also assessed.</abstract><cop>New York</cop><pub>Humana Press Inc</pub><pmid>18193361</pmid><doi>10.1007/s12026-007-0060-9</doi><tpages>17</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0257-277X |
| ispartof | Immunologic research, 2008-01, Vol.40 (1), p.18-34 |
| issn | 0257-277X 1559-0755 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70198673 |
| source | MEDLINE; Springer Nature |
| subjects | Allergology Animals Autoimmunity - immunology Biomedical and Life Sciences Biomedicine Cells Communicable Diseases - immunology Humans Immunology Internal Medicine Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Ligands Medicine/Public Health Neoplasms - immunology NK Cell Lectin-Like Receptor Subfamily K Receptors, Immunologic - metabolism Receptors, Immunologic - physiology Receptors, Natural Killer Cell Signal Transduction - immunology Studies |
| title | The NKG2D receptor: immunobiology and clinical implications |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T21%3A21%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20NKG2D%20receptor:%20immunobiology%20and%20clinical%20implications&rft.jtitle=Immunologic%20research&rft.au=Burgess,%20Steven%20J.&rft.date=2008-01-01&rft.volume=40&rft.issue=1&rft.spage=18&rft.epage=34&rft.pages=18-34&rft.issn=0257-277X&rft.eissn=1559-0755&rft_id=info:doi/10.1007/s12026-007-0060-9&rft_dat=%3Cproquest_cross%3E1897192491%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=195903599&rft_id=info:pmid/18193361&rfr_iscdi=true |