Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers
Autologous Preparation Rich in Growth Factors (PRGF), a small volume of plasma enriched in platelets, is a novel therapeutic strategy for the acceleration of the wound healing of a wide range of tissues because of the continuous release of multiple growth factors, including PDGF‐AB, TGF‐β1, IGF‐I, H...
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| Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2008-02, Vol.84B (2), p.415-421 |
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| container_title | Journal of biomedical materials research. Part B, Applied biomaterials |
| container_volume | 84B |
| creator | Anitua, Eduardo Aguirre, José J. Algorta, Jaime Ayerdi, Eduardo Cabezas, Ana I. Orive, Gorka Andia, Isabel |
| description | Autologous Preparation Rich in Growth Factors (PRGF), a small volume of plasma enriched in platelets, is a novel therapeutic strategy for the acceleration of the wound healing of a wide range of tissues because of the continuous release of multiple growth factors, including PDGF‐AB, TGF‐β1, IGF‐I, HGF, VEGF‐A, and EGF. In this article, we have characterized the PRGF preparation and designed a randomized open‐label controlled pilot trial to evaluate the effectiveness of PRGF in the treatment of chronic cutaneous ulcers. Results showed that at 8 weeks, the mean percentage of surface healed in the PRGF group was 72.94% ± 22.25% whereas it was 21.48% ± 33.56% in the control group (p < 0.05). These results, with the limitations of a pilot study, suggest that topical application of PRGF is more effective than standard therapy in helping a chronic ulcer to heal. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2008 |
| doi_str_mv | 10.1002/jbm.b.30886 |
| format | Article |
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In this article, we have characterized the PRGF preparation and designed a randomized open‐label controlled pilot trial to evaluate the effectiveness of PRGF in the treatment of chronic cutaneous ulcers. Results showed that at 8 weeks, the mean percentage of surface healed in the PRGF group was 72.94% ± 22.25% whereas it was 21.48% ± 33.56% in the control group (p < 0.05). These results, with the limitations of a pilot study, suggest that topical application of PRGF is more effective than standard therapy in helping a chronic ulcer to heal. © 2007 Wiley Periodicals, Inc. 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Part B, Applied biomaterials</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Autologous Preparation Rich in Growth Factors (PRGF), a small volume of plasma enriched in platelets, is a novel therapeutic strategy for the acceleration of the wound healing of a wide range of tissues because of the continuous release of multiple growth factors, including PDGF‐AB, TGF‐β1, IGF‐I, HGF, VEGF‐A, and EGF. In this article, we have characterized the PRGF preparation and designed a randomized open‐label controlled pilot trial to evaluate the effectiveness of PRGF in the treatment of chronic cutaneous ulcers. Results showed that at 8 weeks, the mean percentage of surface healed in the PRGF group was 72.94% ± 22.25% whereas it was 21.48% ± 33.56% in the control group (p < 0.05). These results, with the limitations of a pilot study, suggest that topical application of PRGF is more effective than standard therapy in helping a chronic ulcer to heal. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2008</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood Transfusion, Autologous</subject><subject>chronic cutaneous ulcers</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>growth factors</subject><subject>Humans</subject><subject>Intercellular Signaling Peptides and Proteins - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pilot Projects</subject><subject>platelet</subject><subject>Platelet Transfusion</subject><subject>PRGF</subject><subject>randomized trial</subject><subject>Skin Ulcer - therapy</subject><subject>Wound Healing - physiology</subject><issn>1552-4973</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQRi0EomXhxB35xAVlsePYjo9sVQqlwKUIiYtlO-OuSxIvtkPpvydLlnKjp5mR3jyN5kPoOSVrSkj9-toOa7tmpG3FA3RMOa-rRrX04V0v2RF6kvP1DAvC2WN0RCVXnLD6GPWn3oMr4SeMkDOOHpupxD5exSnjXYKdSaaEOOIU3BaHEV-leFO22BtXYsrYx4TLFnBJYMoAY9kr3DbFMTjspmJG2Jum3kHKT9Ejb_oMzw51hb68Pb08eVddfD57f_LmonKN4qISnesE9V1rgSnVUGmca6W3xs9DKwyFltvaEiMoMcw2rDGNVEw2tKOKsYat0MvFu0vxxwS56CFkB32_XKMloaplRN0LMjp_inN2L1gTTqmYX7pCrxbQpZhzAq93KQwm3WpK9D4uPcelrf4T10y_OGgnO0D3jz3kMwN0AW5CD7f_c-nzzce_0mrZCbnAr7sdk75rIZnk-uunM33-gV9uNuSbVuw3hnGweg</recordid><startdate>200802</startdate><enddate>200802</enddate><creator>Anitua, Eduardo</creator><creator>Aguirre, José J.</creator><creator>Algorta, Jaime</creator><creator>Ayerdi, Eduardo</creator><creator>Cabezas, Ana I.</creator><creator>Orive, Gorka</creator><creator>Andia, Isabel</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>200802</creationdate><title>Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers</title><author>Anitua, Eduardo ; Aguirre, José J. ; Algorta, Jaime ; Ayerdi, Eduardo ; Cabezas, Ana I. ; Orive, Gorka ; Andia, Isabel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4956-6dcd61fd8be399417acc87fbaf94186a1e85b2b0a610a3b434a4793741d193343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Blood Transfusion, Autologous</topic><topic>chronic cutaneous ulcers</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>growth factors</topic><topic>Humans</topic><topic>Intercellular Signaling Peptides and Proteins - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pilot Projects</topic><topic>platelet</topic><topic>Platelet Transfusion</topic><topic>PRGF</topic><topic>randomized trial</topic><topic>Skin Ulcer - therapy</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anitua, Eduardo</creatorcontrib><creatorcontrib>Aguirre, José J.</creatorcontrib><creatorcontrib>Algorta, Jaime</creatorcontrib><creatorcontrib>Ayerdi, Eduardo</creatorcontrib><creatorcontrib>Cabezas, Ana I.</creatorcontrib><creatorcontrib>Orive, Gorka</creatorcontrib><creatorcontrib>Andia, Isabel</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research. 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These results, with the limitations of a pilot study, suggest that topical application of PRGF is more effective than standard therapy in helping a chronic ulcer to heal. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2008</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17595032</pmid><doi>10.1002/jbm.b.30886</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Blood Transfusion, Autologous chronic cutaneous ulcers Chronic Disease Female growth factors Humans Intercellular Signaling Peptides and Proteins - therapeutic use Male Middle Aged Pilot Projects platelet Platelet Transfusion PRGF randomized trial Skin Ulcer - therapy Wound Healing - physiology |
| title | Effectiveness of autologous preparation rich in growth factors for the treatment of chronic cutaneous ulcers |
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