Impact of rosiglitazone on beta-cell function, insulin resistance, and adiponectin concentrations: results from a double-blind oral combination study with glimepiride

Addition of rosiglitazone to sulfonylurea has been shown to improve glycemic control in patients with type 2 diabetes previously treated with sulfonylurea monotherapy alone. This investigation was performed to assess the specific impact of rosiglitazone on insulin resistance, beta-cell function, car...

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Veröffentlicht in:	Metabolism, clinical and experimental clinical and experimental, 2006, Vol.55 (1), p.20-25
Hauptverfasser:	Pfützner, Andreas, Schöndorf, Thomas, Seidel, Daniela, Winkler, Karl, Matthaei, Stephan, Hamann, Andreas, Forst, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin - blood Aged Biological and medical sciences C-Reactive Protein - metabolism Cardiovascular Diseases - epidemiology Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Dose-Response Relationship, Drug Double-Blind Method Drug Combinations Female Glycated Hemoglobin A - metabolism Humans Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Insulin - blood Insulin Resistance - physiology Insulin-Secreting Cells - drug effects Male Medical sciences Metabolic diseases Middle Aged Pancreatic Function Tests Proinsulin - blood Prospective Studies Risk Factors Sulfonylurea Compounds - pharmacology Thiazolidinediones - pharmacology Thiazolidinediones - therapeutic use
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