Development of natural antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A and pneumolysin in Filipino pregnant women and their infants in relation to pneumococcal carriage
For vaccine development it is important to know how antibodies develop after natural pneumococcal contacts. This work was done to receive information about the development of natural antibodies to pneumococcal surface protein A (PspA), pneumococcal surface adhesin A (PsaA) and pneumolysin (Ply), in...
Gespeichert in:
| Veröffentlicht in: | Vaccine 2006-01, Vol.24 (1), p.57-65 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 65 |
|---|---|
| container_issue | 1 |
| container_start_page | 57 |
| container_title | Vaccine |
| container_volume | 24 |
| creator | Holmlund, Emma Quiambao, Beatriz Ollgren, Jukka Nohynek, Hanna Käyhty, Helena |
| description | For vaccine development it is important to know how antibodies develop after natural pneumococcal contacts. This work was done to receive information about the development of natural antibodies to pneumococcal surface protein A (PspA), pneumococcal surface adhesin A (PsaA) and pneumolysin (Ply), in early infancy and to receive information on how nasopharyngeal carriage of
Streptococcus pneumoniae in infants affects the antibody concentrations. The antibody concentrations to PspA, PsaA and Ply were measured by EIA in serum samples of 51 pregnant women, in six consecutive serum samples of 173 infants (samples from 7 to 48 weeks of age), as well as in 39 cord bloods. Nasopharyngeal swabs were also collected from the infants and cultured for pneumococci. The geometric mean concentration (GMC) of anti-PspA and -Ply decreased until 18 weeks of age and started to increase thereafter, but was still at 48 weeks lower than in the mothers. The GMC of anti-PsaA in the infants increased significantly by age and reached the GMC of the mothers already at 14 weeks of age. The increase in antibody concentration in the infants was associated with pneumococcal carriage, but followed the different kinetics depending on the antigen. High maternal anti-Ply antibodies were negatively associated with the risk of pneumococcal carriage (OR 0.78, 0.61–0.99). This indicates that high maternal anti-Ply could be associated with lower pneumococcal carriage acquisition in infants. |
| doi_str_mv | 10.1016/j.vaccine.2005.07.055 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70197874</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0264410X05007310</els_id><sourcerecordid>3379189741</sourcerecordid><originalsourceid>FETCH-LOGICAL-c452t-67a313b0db0daeefce936dbde63571b299987ec9c1e3010da2664cc193dd410e3</originalsourceid><addsrcrecordid>eNqFktGK1TAQhoso7nH1EZSC6JWtSdMk7ZUs664KC94oeBfSZLqbQ5vUpD2yD-h7Od1TWFBhYSAw8-XPzOTPspeUlJRQ8X5fHrQxzkNZEcJLIkvC-aNsRxvJiorT5nG2I5Woi5qSHyfZs5T2BEFG26fZCRWUcknYLvv9EQ4whGkEP-ehz72el6iHXPvZdcE6SPkc8snDMgYTjMFSWmKvDeRTDDM4n5-9-39d2xtIax3F7IYMt2sG49INbnIepSNce3wt_xWwhzt0vgEXEeoxnVY4wqBnF_w_rRgdo9PX8Dx70ushwYvtPM2-X158O_9cXH399OX87KowNa_mQkjNKOuIxdAAvYGWCdtZEIxL2lVt2zYSTGsoMEKRqYSojaEtsxbXCOw0e3vUxdl_LpBmNbpkYBi0h7AkJQltZSPrB0Eqq5oxQRF8_Re4D0v0OISivJaEt6JhSPEjZWJIKUKvpuhGHW8VJWq1g9qrzQ5qtYMiUqEd8N6rTX3pRrD3t7b_R-DNBuiEC-2j9sale04y2YhGIPfhyAFu9-AgqmQceAPWRTCzssE90MofXCPavA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1547059683</pqid></control><display><type>article</type><title>Development of natural antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A and pneumolysin in Filipino pregnant women and their infants in relation to pneumococcal carriage</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Holmlund, Emma ; Quiambao, Beatriz ; Ollgren, Jukka ; Nohynek, Hanna ; Käyhty, Helena</creator><creatorcontrib>Holmlund, Emma ; Quiambao, Beatriz ; Ollgren, Jukka ; Nohynek, Hanna ; Käyhty, Helena</creatorcontrib><description>For vaccine development it is important to know how antibodies develop after natural pneumococcal contacts. This work was done to receive information about the development of natural antibodies to pneumococcal surface protein A (PspA), pneumococcal surface adhesin A (PsaA) and pneumolysin (Ply), in early infancy and to receive information on how nasopharyngeal carriage of
Streptococcus pneumoniae in infants affects the antibody concentrations. The antibody concentrations to PspA, PsaA and Ply were measured by EIA in serum samples of 51 pregnant women, in six consecutive serum samples of 173 infants (samples from 7 to 48 weeks of age), as well as in 39 cord bloods. Nasopharyngeal swabs were also collected from the infants and cultured for pneumococci. The geometric mean concentration (GMC) of anti-PspA and -Ply decreased until 18 weeks of age and started to increase thereafter, but was still at 48 weeks lower than in the mothers. The GMC of anti-PsaA in the infants increased significantly by age and reached the GMC of the mothers already at 14 weeks of age. The increase in antibody concentration in the infants was associated with pneumococcal carriage, but followed the different kinetics depending on the antigen. High maternal anti-Ply antibodies were negatively associated with the risk of pneumococcal carriage (OR 0.78, 0.61–0.99). This indicates that high maternal anti-Ply could be associated with lower pneumococcal carriage acquisition in infants.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2005.07.055</identifier><identifier>PMID: 16115703</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adhesins, Bacterial - immunology ; Age ; Antibodies, Bacterial - blood ; Applied microbiology ; Bacterial Proteins - immunology ; Bacteriology ; Biological and medical sciences ; Disease ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunity, Maternally-Acquired ; Infant ; Infant, Newborn ; Infants ; Logistic Models ; Maternal antibodies ; Microbiology ; Miscellaneous ; Mothers ; Nasopharynx - microbiology ; Pneumococcal carriage ; Pneumococcal protein antibodies ; Pneumococcal Vaccines - immunology ; Pneumonia ; Pregnancy ; Proteins ; Streptococcus infections ; Streptococcus pneumoniae ; Streptococcus pneumoniae - immunology ; Streptococcus pneumoniae - isolation & purification ; Streptolysins - immunology ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2006-01, Vol.24 (1), p.57-65</ispartof><rights>2005 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jan 9, 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-67a313b0db0daeefce936dbde63571b299987ec9c1e3010da2664cc193dd410e3</citedby><cites>FETCH-LOGICAL-c452t-67a313b0db0daeefce936dbde63571b299987ec9c1e3010da2664cc193dd410e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X05007310$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17378686$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16115703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holmlund, Emma</creatorcontrib><creatorcontrib>Quiambao, Beatriz</creatorcontrib><creatorcontrib>Ollgren, Jukka</creatorcontrib><creatorcontrib>Nohynek, Hanna</creatorcontrib><creatorcontrib>Käyhty, Helena</creatorcontrib><title>Development of natural antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A and pneumolysin in Filipino pregnant women and their infants in relation to pneumococcal carriage</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>For vaccine development it is important to know how antibodies develop after natural pneumococcal contacts. This work was done to receive information about the development of natural antibodies to pneumococcal surface protein A (PspA), pneumococcal surface adhesin A (PsaA) and pneumolysin (Ply), in early infancy and to receive information on how nasopharyngeal carriage of
Streptococcus pneumoniae in infants affects the antibody concentrations. The antibody concentrations to PspA, PsaA and Ply were measured by EIA in serum samples of 51 pregnant women, in six consecutive serum samples of 173 infants (samples from 7 to 48 weeks of age), as well as in 39 cord bloods. Nasopharyngeal swabs were also collected from the infants and cultured for pneumococci. The geometric mean concentration (GMC) of anti-PspA and -Ply decreased until 18 weeks of age and started to increase thereafter, but was still at 48 weeks lower than in the mothers. The GMC of anti-PsaA in the infants increased significantly by age and reached the GMC of the mothers already at 14 weeks of age. The increase in antibody concentration in the infants was associated with pneumococcal carriage, but followed the different kinetics depending on the antigen. High maternal anti-Ply antibodies were negatively associated with the risk of pneumococcal carriage (OR 0.78, 0.61–0.99). This indicates that high maternal anti-Ply could be associated with lower pneumococcal carriage acquisition in infants.</description><subject>Adhesins, Bacterial - immunology</subject><subject>Age</subject><subject>Antibodies, Bacterial - blood</subject><subject>Applied microbiology</subject><subject>Bacterial Proteins - immunology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Disease</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunity, Maternally-Acquired</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infants</subject><subject>Logistic Models</subject><subject>Maternal antibodies</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Mothers</subject><subject>Nasopharynx - microbiology</subject><subject>Pneumococcal carriage</subject><subject>Pneumococcal protein antibodies</subject><subject>Pneumococcal Vaccines - immunology</subject><subject>Pneumonia</subject><subject>Pregnancy</subject><subject>Proteins</subject><subject>Streptococcus infections</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - immunology</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><subject>Streptolysins - immunology</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFktGK1TAQhoso7nH1EZSC6JWtSdMk7ZUs664KC94oeBfSZLqbQ5vUpD2yD-h7Od1TWFBhYSAw8-XPzOTPspeUlJRQ8X5fHrQxzkNZEcJLIkvC-aNsRxvJiorT5nG2I5Woi5qSHyfZs5T2BEFG26fZCRWUcknYLvv9EQ4whGkEP-ehz72el6iHXPvZdcE6SPkc8snDMgYTjMFSWmKvDeRTDDM4n5-9-39d2xtIax3F7IYMt2sG49INbnIepSNce3wt_xWwhzt0vgEXEeoxnVY4wqBnF_w_rRgdo9PX8Dx70ushwYvtPM2-X158O_9cXH399OX87KowNa_mQkjNKOuIxdAAvYGWCdtZEIxL2lVt2zYSTGsoMEKRqYSojaEtsxbXCOw0e3vUxdl_LpBmNbpkYBi0h7AkJQltZSPrB0Eqq5oxQRF8_Re4D0v0OISivJaEt6JhSPEjZWJIKUKvpuhGHW8VJWq1g9qrzQ5qtYMiUqEd8N6rTX3pRrD3t7b_R-DNBuiEC-2j9sale04y2YhGIPfhyAFu9-AgqmQceAPWRTCzssE90MofXCPavA</recordid><startdate>20060109</startdate><enddate>20060109</enddate><creator>Holmlund, Emma</creator><creator>Quiambao, Beatriz</creator><creator>Ollgren, Jukka</creator><creator>Nohynek, Hanna</creator><creator>Käyhty, Helena</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20060109</creationdate><title>Development of natural antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A and pneumolysin in Filipino pregnant women and their infants in relation to pneumococcal carriage</title><author>Holmlund, Emma ; Quiambao, Beatriz ; Ollgren, Jukka ; Nohynek, Hanna ; Käyhty, Helena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-67a313b0db0daeefce936dbde63571b299987ec9c1e3010da2664cc193dd410e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adhesins, Bacterial - immunology</topic><topic>Age</topic><topic>Antibodies, Bacterial - blood</topic><topic>Applied microbiology</topic><topic>Bacterial Proteins - immunology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Disease</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunity, Maternally-Acquired</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infants</topic><topic>Logistic Models</topic><topic>Maternal antibodies</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Mothers</topic><topic>Nasopharynx - microbiology</topic><topic>Pneumococcal carriage</topic><topic>Pneumococcal protein antibodies</topic><topic>Pneumococcal Vaccines - immunology</topic><topic>Pneumonia</topic><topic>Pregnancy</topic><topic>Proteins</topic><topic>Streptococcus infections</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - immunology</topic><topic>Streptococcus pneumoniae - isolation & purification</topic><topic>Streptolysins - immunology</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holmlund, Emma</creatorcontrib><creatorcontrib>Quiambao, Beatriz</creatorcontrib><creatorcontrib>Ollgren, Jukka</creatorcontrib><creatorcontrib>Nohynek, Hanna</creatorcontrib><creatorcontrib>Käyhty, Helena</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Biological Sciences</collection><collection>ProQuest Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Healthcare Administration Database</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holmlund, Emma</au><au>Quiambao, Beatriz</au><au>Ollgren, Jukka</au><au>Nohynek, Hanna</au><au>Käyhty, Helena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of natural antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A and pneumolysin in Filipino pregnant women and their infants in relation to pneumococcal carriage</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2006-01-09</date><risdate>2006</risdate><volume>24</volume><issue>1</issue><spage>57</spage><epage>65</epage><pages>57-65</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>For vaccine development it is important to know how antibodies develop after natural pneumococcal contacts. This work was done to receive information about the development of natural antibodies to pneumococcal surface protein A (PspA), pneumococcal surface adhesin A (PsaA) and pneumolysin (Ply), in early infancy and to receive information on how nasopharyngeal carriage of
Streptococcus pneumoniae in infants affects the antibody concentrations. The antibody concentrations to PspA, PsaA and Ply were measured by EIA in serum samples of 51 pregnant women, in six consecutive serum samples of 173 infants (samples from 7 to 48 weeks of age), as well as in 39 cord bloods. Nasopharyngeal swabs were also collected from the infants and cultured for pneumococci. The geometric mean concentration (GMC) of anti-PspA and -Ply decreased until 18 weeks of age and started to increase thereafter, but was still at 48 weeks lower than in the mothers. The GMC of anti-PsaA in the infants increased significantly by age and reached the GMC of the mothers already at 14 weeks of age. The increase in antibody concentration in the infants was associated with pneumococcal carriage, but followed the different kinetics depending on the antigen. High maternal anti-Ply antibodies were negatively associated with the risk of pneumococcal carriage (OR 0.78, 0.61–0.99). This indicates that high maternal anti-Ply could be associated with lower pneumococcal carriage acquisition in infants.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16115703</pmid><doi>10.1016/j.vaccine.2005.07.055</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2006-01, Vol.24 (1), p.57-65 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70197874 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adhesins, Bacterial - immunology Age Antibodies, Bacterial - blood Applied microbiology Bacterial Proteins - immunology Bacteriology Biological and medical sciences Disease Female Fundamental and applied biological sciences. Psychology Humans Immunity, Maternally-Acquired Infant Infant, Newborn Infants Logistic Models Maternal antibodies Microbiology Miscellaneous Mothers Nasopharynx - microbiology Pneumococcal carriage Pneumococcal protein antibodies Pneumococcal Vaccines - immunology Pneumonia Pregnancy Proteins Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - immunology Streptococcus pneumoniae - isolation & purification Streptolysins - immunology Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Development of natural antibodies to pneumococcal surface protein A, pneumococcal surface adhesin A and pneumolysin in Filipino pregnant women and their infants in relation to pneumococcal carriage |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T18%3A49%3A47IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20natural%20antibodies%20to%20pneumococcal%20surface%20protein%20A,%20pneumococcal%20surface%20adhesin%20A%20and%20pneumolysin%20in%20Filipino%20pregnant%20women%20and%20their%20infants%20in%20relation%20to%20pneumococcal%20carriage&rft.jtitle=Vaccine&rft.au=Holmlund,%20Emma&rft.date=2006-01-09&rft.volume=24&rft.issue=1&rft.spage=57&rft.epage=65&rft.pages=57-65&rft.issn=0264-410X&rft.eissn=1873-2518&rft.coden=VACCDE&rft_id=info:doi/10.1016/j.vaccine.2005.07.055&rft_dat=%3Cproquest_cross%3E3379189741%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1547059683&rft_id=info:pmid/16115703&rft_els_id=S0264410X05007310&rfr_iscdi=true |