Blood banking-induced alteration of red blood cell flow properties
BACKGROUND: Blood banking procedures are associated with damage to red blood cell (RBC) membranes, which can impair their flow properties, namely, their deformability, aggregability, and adherence to endothelial cells (ECs) and thus possibly introducing a circulatory risk to recipients. This study w...
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| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2008-01, Vol.48 (1), p.136-146 |
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| creator | Relevy, Hanna Koshkaryev, Alexander Manny, Noga Yedgar, Saul Barshtein, Gregory |
| description | BACKGROUND: Blood banking procedures are associated with damage to red blood cell (RBC) membranes, which can impair their flow properties, namely, their deformability, aggregability, and adherence to endothelial cells (ECs) and thus possibly introducing a circulatory risk to recipients. This study was undertaken to comprehensively explore the effect of cold storage and gamma irradiation on RBC flow properties.
STUDY DESIGN AND METHODS: RBC flow properties were monitored as a function of shear stress with a computerized cell flow properties analyzer. Because we had previously studied storage effect on RBC aggregability (Transfusion 1999;39:277‐81), here we determined the storage effect on RBC adherence and deformability, by measuring them before (control) and during storage. Gamma irradiation effect on RBC aggregability, adherence, and deformability was determined before (control) and after irradiation.
RESULTS: Cold storage significantly elevated the number of adherent RBCs and the strength of their interaction with ECs, and was marked by decreased RBC deformability as early as 2 weeks into the storage period. The elevation of RBC–EC interaction was well correlated with translocation of phosphatidylserine to the RBC surface. Gamma irradiation induced an immediate and marked increase in the number of rigid cells, but did not affect RBC adherence and aggregability.
CONCLUSION: RBC flow properties appear to be especially sensitive to cold storage and gamma irradiation because they are impaired long before the expiration date. Because impaired RBC flow properties facilitate circulatory disorders, the potential circulatory risk of transfusion RBC with blood banking–impaired rheology should be considered. |
| doi_str_mv | 10.1111/j.1537-2995.2007.01491.x |
| format | Article |
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STUDY DESIGN AND METHODS: RBC flow properties were monitored as a function of shear stress with a computerized cell flow properties analyzer. Because we had previously studied storage effect on RBC aggregability (Transfusion 1999;39:277‐81), here we determined the storage effect on RBC adherence and deformability, by measuring them before (control) and during storage. Gamma irradiation effect on RBC aggregability, adherence, and deformability was determined before (control) and after irradiation.
RESULTS: Cold storage significantly elevated the number of adherent RBCs and the strength of their interaction with ECs, and was marked by decreased RBC deformability as early as 2 weeks into the storage period. The elevation of RBC–EC interaction was well correlated with translocation of phosphatidylserine to the RBC surface. Gamma irradiation induced an immediate and marked increase in the number of rigid cells, but did not affect RBC adherence and aggregability.
CONCLUSION: RBC flow properties appear to be especially sensitive to cold storage and gamma irradiation because they are impaired long before the expiration date. Because impaired RBC flow properties facilitate circulatory disorders, the potential circulatory risk of transfusion RBC with blood banking–impaired rheology should be considered.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/j.1537-2995.2007.01491.x</identifier><identifier>PMID: 17900281</identifier><identifier>CODEN: TRANAT</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Blood Banks - standards ; Blood Circulation ; Blood Preservation - adverse effects ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Cell Adhesion ; Cells, Cultured ; Cold Temperature ; Erythrocyte Aggregation ; Erythrocyte Deformability ; Erythrocytes - cytology ; Erythrocytes - physiology ; Erythrocytes - radiation effects ; Gamma Rays ; Hemorheology ; Humans ; Medical sciences ; Stress, Mechanical ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>Transfusion (Philadelphia, Pa.), 2008-01, Vol.48 (1), p.136-146</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5521-ad4792c038461b1c5434864b91a3502ab95779fb778f6c4ae9c8bcd76e0e6c7d3</citedby><cites>FETCH-LOGICAL-c5521-ad4792c038461b1c5434864b91a3502ab95779fb778f6c4ae9c8bcd76e0e6c7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1537-2995.2007.01491.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1537-2995.2007.01491.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20029115$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17900281$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Relevy, Hanna</creatorcontrib><creatorcontrib>Koshkaryev, Alexander</creatorcontrib><creatorcontrib>Manny, Noga</creatorcontrib><creatorcontrib>Yedgar, Saul</creatorcontrib><creatorcontrib>Barshtein, Gregory</creatorcontrib><title>Blood banking-induced alteration of red blood cell flow properties</title><title>Transfusion (Philadelphia, Pa.)</title><addtitle>Transfusion</addtitle><description>BACKGROUND: Blood banking procedures are associated with damage to red blood cell (RBC) membranes, which can impair their flow properties, namely, their deformability, aggregability, and adherence to endothelial cells (ECs) and thus possibly introducing a circulatory risk to recipients. This study was undertaken to comprehensively explore the effect of cold storage and gamma irradiation on RBC flow properties.
STUDY DESIGN AND METHODS: RBC flow properties were monitored as a function of shear stress with a computerized cell flow properties analyzer. Because we had previously studied storage effect on RBC aggregability (Transfusion 1999;39:277‐81), here we determined the storage effect on RBC adherence and deformability, by measuring them before (control) and during storage. Gamma irradiation effect on RBC aggregability, adherence, and deformability was determined before (control) and after irradiation.
RESULTS: Cold storage significantly elevated the number of adherent RBCs and the strength of their interaction with ECs, and was marked by decreased RBC deformability as early as 2 weeks into the storage period. The elevation of RBC–EC interaction was well correlated with translocation of phosphatidylserine to the RBC surface. Gamma irradiation induced an immediate and marked increase in the number of rigid cells, but did not affect RBC adherence and aggregability.
CONCLUSION: RBC flow properties appear to be especially sensitive to cold storage and gamma irradiation because they are impaired long before the expiration date. Because impaired RBC flow properties facilitate circulatory disorders, the potential circulatory risk of transfusion RBC with blood banking–impaired rheology should be considered.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Blood Banks - standards</subject><subject>Blood Circulation</subject><subject>Blood Preservation - adverse effects</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Cell Adhesion</subject><subject>Cells, Cultured</subject><subject>Cold Temperature</subject><subject>Erythrocyte Aggregation</subject><subject>Erythrocyte Deformability</subject><subject>Erythrocytes - cytology</subject><subject>Erythrocytes - physiology</subject><subject>Erythrocytes - radiation effects</subject><subject>Gamma Rays</subject><subject>Hemorheology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Stress, Mechanical</subject><subject>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1PwyAUhonR6Jz-BdMbvWvlUFrKjYlbnB9Z1OiMl4RSati6dkKXzX8v3ZZ5KzecwHPec_IgFACOwJ_raQRJzELCeRIRjFmEgXKI1geot_84RD2MKYQAMTlBp85NMcaEYzhGJ8C4rzPoocGgapoiyGU9M_VXaOpiqXQRyKrVVramqYOmDKx_yTec0lUVlFWzCha2WWjbGu3O0FEpK6fPd3cffYzuJsOHcPxy_zi8HYcqSQiEsqCME4XjjKaQg0poTLOU5hxknGAic54wxsucsaxMFZWaqyxXBUs11qliRdxHV9tcP_p7qV0r5sZ1C8laN0snGAbOfIQHsy2obOOc1aVYWDOX9kcAFp0_MRWdJtFpEp0_sfEn1r71Yjdjmc918de4E-aByx0gnZJVaWWtjNtzpFMMPryPbrbcylT6598LiMnbaFP6gHAbYFyr1_sAaWciZTFLxOfzvXgYvj5l6TsRNP4FpJuZug</recordid><startdate>200801</startdate><enddate>200801</enddate><creator>Relevy, Hanna</creator><creator>Koshkaryev, Alexander</creator><creator>Manny, Noga</creator><creator>Yedgar, Saul</creator><creator>Barshtein, Gregory</creator><general>Blackwell Publishing Inc</general><general>Blackwell Publishing</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200801</creationdate><title>Blood banking-induced alteration of red blood cell flow properties</title><author>Relevy, Hanna ; Koshkaryev, Alexander ; Manny, Noga ; Yedgar, Saul ; Barshtein, Gregory</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5521-ad4792c038461b1c5434864b91a3502ab95779fb778f6c4ae9c8bcd76e0e6c7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Blood Banks - standards</topic><topic>Blood Circulation</topic><topic>Blood Preservation - adverse effects</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Cell Adhesion</topic><topic>Cells, Cultured</topic><topic>Cold Temperature</topic><topic>Erythrocyte Aggregation</topic><topic>Erythrocyte Deformability</topic><topic>Erythrocytes - cytology</topic><topic>Erythrocytes - physiology</topic><topic>Erythrocytes - radiation effects</topic><topic>Gamma Rays</topic><topic>Hemorheology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Stress, Mechanical</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Relevy, Hanna</creatorcontrib><creatorcontrib>Koshkaryev, Alexander</creatorcontrib><creatorcontrib>Manny, Noga</creatorcontrib><creatorcontrib>Yedgar, Saul</creatorcontrib><creatorcontrib>Barshtein, Gregory</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Relevy, Hanna</au><au>Koshkaryev, Alexander</au><au>Manny, Noga</au><au>Yedgar, Saul</au><au>Barshtein, Gregory</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood banking-induced alteration of red blood cell flow properties</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><addtitle>Transfusion</addtitle><date>2008-01</date><risdate>2008</risdate><volume>48</volume><issue>1</issue><spage>136</spage><epage>146</epage><pages>136-146</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><coden>TRANAT</coden><abstract>BACKGROUND: Blood banking procedures are associated with damage to red blood cell (RBC) membranes, which can impair their flow properties, namely, their deformability, aggregability, and adherence to endothelial cells (ECs) and thus possibly introducing a circulatory risk to recipients. This study was undertaken to comprehensively explore the effect of cold storage and gamma irradiation on RBC flow properties.
STUDY DESIGN AND METHODS: RBC flow properties were monitored as a function of shear stress with a computerized cell flow properties analyzer. Because we had previously studied storage effect on RBC aggregability (Transfusion 1999;39:277‐81), here we determined the storage effect on RBC adherence and deformability, by measuring them before (control) and during storage. Gamma irradiation effect on RBC aggregability, adherence, and deformability was determined before (control) and after irradiation.
RESULTS: Cold storage significantly elevated the number of adherent RBCs and the strength of their interaction with ECs, and was marked by decreased RBC deformability as early as 2 weeks into the storage period. The elevation of RBC–EC interaction was well correlated with translocation of phosphatidylserine to the RBC surface. Gamma irradiation induced an immediate and marked increase in the number of rigid cells, but did not affect RBC adherence and aggregability.
CONCLUSION: RBC flow properties appear to be especially sensitive to cold storage and gamma irradiation because they are impaired long before the expiration date. Because impaired RBC flow properties facilitate circulatory disorders, the potential circulatory risk of transfusion RBC with blood banking–impaired rheology should be considered.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17900281</pmid><doi>10.1111/j.1537-2995.2007.01491.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Banks - standards Blood Circulation Blood Preservation - adverse effects Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Bone marrow, stem cells transplantation. Graft versus host reaction Cell Adhesion Cells, Cultured Cold Temperature Erythrocyte Aggregation Erythrocyte Deformability Erythrocytes - cytology Erythrocytes - physiology Erythrocytes - radiation effects Gamma Rays Hemorheology Humans Medical sciences Stress, Mechanical Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Blood banking-induced alteration of red blood cell flow properties |
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