Acetoxy drug: Protein transacetylase catalyzed activation of human platelet nitric oxide synthase by polyphenolic peracetates

Polyphenolic acetates are the novel potent enhancers of intracellular nitric oxide. An enhanced intracellular level of Nitric oxide (NO) is essential to ameliorate several pathological conditions of heart and vasculature necessitating the activation of NOS. We have projected in this report the acety...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-01, Vol.14 (2), p.575-583
Hauptverfasser:	Khurana, Pulkit, Kumari, Ranju, Vohra, Parag, Kumar, Ajit, Seema, Gupta, Garima, Raj, Hanumantharao G., Dwarakanath, Bilikere S., Parmar, Virinder S., Saluja, Daman, Bose, Mridula, Vij, Anjana, Chaudhary, Nabo K., Adhikari, Jawahar S., Tyagi, Yogesh K., Kohli, Ekta
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetates - chemistry Acetates - pharmacology Acetylation Acyltransferases - metabolism Biological and medical sciences Blood Platelets - enzymology Blood. Blood coagulation. Reticuloendothelial system Blotting, Western Cardiovascular system Catalysis Cytochromes c - metabolism Enzyme Activation Flavonoids - chemistry Humans Medical sciences Microscopy, Confocal Miscellaneous Nitric oxide Nitric oxide synthase Nitric Oxide Synthase - metabolism Pharmacology. Drug treatments Phenols - chemistry Platelet aggregation Polyphenolic peracetate Polyphenols Protein acetylation Transacetylase
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