Guanine-specific DNA damage photosensitized by the dihydroxo(tetraphenylporphyrinato)antimony(V) complex

The dihydroxo(tetraphenylporphyrinato)antimony(V) complex (SbTPP) demonstrates bactericidal activity under visible-light irradiation. This phototoxic effect could be caused by photodamage to biomolecules, but the mechanism has not been well understood. In this study, to clarify the mechanism of phot...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 2006-01, Vol.82 (1), p.37-44
Hauptverfasser:	Hirakawa, Kazutaka, Kawanishi, Shosuke, Matsumoto, Jin, Shiragami, Tsutomu, Yasuda, Masahide
Format:	Artikel
Sprache:	eng
Schlagworte:	Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism Dihydroxo(tetraphenylporphyrinato)antimony(V) complex DNA - metabolism DNA damage DNA Damage - drug effects DNA, Single-Stranded - metabolism DNA-Formamidopyrimidine Glycosylase - pharmacology Electron transfer Electron Transport - drug effects Escherichia coli Escherichia coli Proteins - pharmacology Guanine - analogs & derivatives Guanine - metabolism Light Membrane Lipids - metabolism Metalloporphyrins - pharmacology Oxidation-Reduction Phospholipids - metabolism Photocatalyst Photosensitizing Agents - pharmacology Piperidines - pharmacology Proteins - metabolism Singlet oxygen Singlet Oxygen - metabolism
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