A Metathesis-Based Approach to the Synthesis of 2-Pyridones and Pyridines

The ring-closing metathesis reaction has been successfully employed to form a range of dihydropyridone intermediates, which are in the correct oxidation state to undergo a base-induced elimination to reveal the aromatic 2-pyridone. This mild and novel approach to six-membered heteroaromatic compound...

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Veröffentlicht in:	Organic letters 2008-01, Vol.10 (2), p.285-288
Hauptverfasser:	Donohoe, Timothy J, Fishlock, Lisa P, Procopiou, Panayiotis A
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Cyclization Molecular Structure Oxidation-Reduction Pyridines - chemical synthesis Pyridines - chemistry Pyridones - chemical synthesis Pyridones - chemistry
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description	The ring-closing metathesis reaction has been successfully employed to form a range of dihydropyridone intermediates, which are in the correct oxidation state to undergo a base-induced elimination to reveal the aromatic 2-pyridone. This mild and novel approach to six-membered heteroaromatic compounds then provides access to a wide variety of substituted pyridines in excellent overall yield.
doi_str_mv	10.1021/ol702684d
format	Article
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source	MEDLINE; American Chemical Society Journals
subjects	Catalysis Cyclization Molecular Structure Oxidation-Reduction Pyridines - chemical synthesis Pyridines - chemistry Pyridones - chemical synthesis Pyridones - chemistry
title	A Metathesis-Based Approach to the Synthesis of 2-Pyridones and Pyridines
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