Reduced sarcoplasmic reticulum Ca2+ -ATPase activity and dephosphorylated phospholamban contribute to contractile dysfunction in human hibernating myocardium

Human hibernating myocardium (HHM) is characterized by reversible contractile dysfunction during chronic ischemia. A disturbed calcium-homeostasis is a decisive factor for reduced functional capacity in heart diseases. We therefore investigated calcium-handling proteins in HHM. In 12 patients suffer...

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Veröffentlicht in:	Molecular and cellular biochemistry 2006-01, Vol.282 (1-2), p.53-63
Hauptverfasser:	Nef, Holger M, Möllmann, Helge, Skwara, Woitek, Bölck, Birgit, Schwinger, Robert H G, Hamm, Ch, Kostin, Sawa, Schaper, Jutta, Elsässer, Albrecht
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Calcium Calcium - metabolism Calcium-Binding Proteins - metabolism Calcium-Transporting ATPases - metabolism Cardiovascular diseases Homeodomain Proteins - metabolism Humans Investigations Microscopy, Electron, Transmission Middle Aged Myocardial Contraction Myocardial Stunning - metabolism Myocardial Stunning - pathology Myocardial Stunning - physiopathology Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - ultrastructure Phosphorylation Proteins Ryanodine Receptor Calcium Release Channel - metabolism Sarcomeres - ultrastructure Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum - ultrastructure Sarcoplasmic Reticulum Calcium-Transporting ATPases Thallium
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