In Vitro Candidacidal Action of Korean Red Ginseng Saponins against Candida albicans
Korean red ginseng saponins (ginsenosides) have been reported as having various biological properties, but the antifungal effects and the mode of action of ginsenosides remain mostly unknown. In this study, saponins were isolated from Korean red ginseng, and the antifungal effects of ginsenosides we...
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| Veröffentlicht in: | Biological & Pharmaceutical Bulletin 2008/01/01, Vol.31(1), pp.139-142 |
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| creator | Sung, Woo Sang Lee, Dong Gun |
| description | Korean red ginseng saponins (ginsenosides) have been reported as having various biological properties, but the antifungal effects and the mode of action of ginsenosides remain mostly unknown. In this study, saponins were isolated from Korean red ginseng, and the antifungal effects of ginsenosides were investigated. Ginsenosides showed fungicidal effects toward pathogenic fungi tested. To elucidate the antifungal mode of action of ginsenosides, flow cytometry analysis and the change in membrane dynamics using 1,6-diphenyl-1,3,5-hexatriene (DPH), as a plasma membrane probe, were performed with Candida albicans. The results suggest that ginsenosides may exert antifungal activity by disrupting the structure of cell membrane. The present study indicates that ginsenosides have considerable antifungal activity, deserving further investigation for clinical applications. |
| doi_str_mv | 10.1248/bpb.31.139 |
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In this study, saponins were isolated from Korean red ginseng, and the antifungal effects of ginsenosides were investigated. Ginsenosides showed fungicidal effects toward pathogenic fungi tested. To elucidate the antifungal mode of action of ginsenosides, flow cytometry analysis and the change in membrane dynamics using 1,6-diphenyl-1,3,5-hexatriene (DPH), as a plasma membrane probe, were performed with Candida albicans. The results suggest that ginsenosides may exert antifungal activity by disrupting the structure of cell membrane. The present study indicates that ginsenosides have considerable antifungal activity, deserving further investigation for clinical applications.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.31.139</identifier><identifier>PMID: 18175957</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>antifungal activity ; Antifungal Agents - pharmacology ; Candida albicans ; Candida albicans - drug effects ; candidacidal activity ; Cell Membrane - drug effects ; ginsenoside ; Ginsenosides - pharmacology ; Korea ; Korean red ginseng ; Membrane Potentials - drug effects ; Panax - chemistry</subject><ispartof>Biological and Pharmaceutical Bulletin, 2008/01/01, Vol.31(1), pp.139-142</ispartof><rights>2008 The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c716t-3ccccf4c2441338e800c660df249a7da4e13b5965ba6b729b5ab0f5d9b7639be3</citedby><cites>FETCH-LOGICAL-c716t-3ccccf4c2441338e800c660df249a7da4e13b5965ba6b729b5ab0f5d9b7639be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18175957$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sung, Woo Sang</creatorcontrib><creatorcontrib>Lee, Dong Gun</creatorcontrib><creatorcontrib>Department of Microbiology</creatorcontrib><creatorcontrib>College of Natural Sciences</creatorcontrib><creatorcontrib>Kyungpook National University</creatorcontrib><title>In Vitro Candidacidal Action of Korean Red Ginseng Saponins against Candida albicans</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Korean red ginseng saponins (ginsenosides) have been reported as having various biological properties, but the antifungal effects and the mode of action of ginsenosides remain mostly unknown. In this study, saponins were isolated from Korean red ginseng, and the antifungal effects of ginsenosides were investigated. Ginsenosides showed fungicidal effects toward pathogenic fungi tested. To elucidate the antifungal mode of action of ginsenosides, flow cytometry analysis and the change in membrane dynamics using 1,6-diphenyl-1,3,5-hexatriene (DPH), as a plasma membrane probe, were performed with Candida albicans. The results suggest that ginsenosides may exert antifungal activity by disrupting the structure of cell membrane. The present study indicates that ginsenosides have considerable antifungal activity, deserving further investigation for clinical applications.</description><subject>antifungal activity</subject><subject>Antifungal Agents - pharmacology</subject><subject>Candida albicans</subject><subject>Candida albicans - drug effects</subject><subject>candidacidal activity</subject><subject>Cell Membrane - drug effects</subject><subject>ginsenoside</subject><subject>Ginsenosides - pharmacology</subject><subject>Korea</subject><subject>Korean red ginseng</subject><subject>Membrane Potentials - drug effects</subject><subject>Panax - chemistry</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVGLEzEQx4MoXj198QNIQLgHoXVmk2w2T3IUrYcHgp6-hiSbrSnbpCbbB7-9Kdu7A18MZCaQ3_xnkj8hrxFW2PDuvT3YFcMVMvWELJBxuRQNiqdkAQq7ZYuiuyAvStkBgISGPScX2KEUSsgFubuJ9GeYcqJrE_vQG1f3SK_dFFKkaaBfUvYm0m--p5sQi49b-t0cUqxnarampum-lJrRBmdieUmeDWYs_tU5X5Ifnz7erT8vb79ubtbXt0snsZ2WzNU1cNdwjox1vgNwbQv90HBlZG-4R2aFaoU1rZWNssJYGESvrGyZsp5dkqtZ95DT76Mvk96H4vw4mujTsWgJqDgK8V-wgZYjyBP49h9wl4451kdo5FwxiQp4pd7NlMuplOwHfchhb_IfjaBPluhqiWaoqyUVfnOWPNq97x_RswcV2MxAva3fN6Y4hugfG7sibUhjqlNCpwEYAmpohIYqXwNvEKCO1VSlD7PSrkxm6x9amTwFN_qHqeZwqr6_cb9M1j6yv6xSskE</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Sung, Woo Sang</creator><creator>Lee, Dong Gun</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>In Vitro Candidacidal Action of Korean Red Ginseng Saponins against Candida albicans</title><author>Sung, Woo Sang ; Lee, Dong Gun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c716t-3ccccf4c2441338e800c660df249a7da4e13b5965ba6b729b5ab0f5d9b7639be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>antifungal activity</topic><topic>Antifungal Agents - pharmacology</topic><topic>Candida albicans</topic><topic>Candida albicans - drug effects</topic><topic>candidacidal activity</topic><topic>Cell Membrane - drug effects</topic><topic>ginsenoside</topic><topic>Ginsenosides - pharmacology</topic><topic>Korea</topic><topic>Korean red ginseng</topic><topic>Membrane Potentials - drug effects</topic><topic>Panax - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sung, Woo Sang</creatorcontrib><creatorcontrib>Lee, Dong Gun</creatorcontrib><creatorcontrib>Department of Microbiology</creatorcontrib><creatorcontrib>College of Natural Sciences</creatorcontrib><creatorcontrib>Kyungpook National University</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Biological & Pharmaceutical Bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sung, Woo Sang</au><au>Lee, Dong Gun</au><aucorp>Department of Microbiology</aucorp><aucorp>College of Natural Sciences</aucorp><aucorp>Kyungpook National University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro Candidacidal Action of Korean Red Ginseng Saponins against Candida albicans</atitle><jtitle>Biological & Pharmaceutical Bulletin</jtitle><addtitle>Biol Pharm Bull</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>31</volume><issue>1</issue><spage>139</spage><epage>142</epage><pages>139-142</pages><issn>0918-6158</issn><eissn>1347-5215</eissn><abstract>Korean red ginseng saponins (ginsenosides) have been reported as having various biological properties, but the antifungal effects and the mode of action of ginsenosides remain mostly unknown. In this study, saponins were isolated from Korean red ginseng, and the antifungal effects of ginsenosides were investigated. Ginsenosides showed fungicidal effects toward pathogenic fungi tested. To elucidate the antifungal mode of action of ginsenosides, flow cytometry analysis and the change in membrane dynamics using 1,6-diphenyl-1,3,5-hexatriene (DPH), as a plasma membrane probe, were performed with Candida albicans. The results suggest that ginsenosides may exert antifungal activity by disrupting the structure of cell membrane. The present study indicates that ginsenosides have considerable antifungal activity, deserving further investigation for clinical applications.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>18175957</pmid><doi>10.1248/bpb.31.139</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | antifungal activity Antifungal Agents - pharmacology Candida albicans Candida albicans - drug effects candidacidal activity Cell Membrane - drug effects ginsenoside Ginsenosides - pharmacology Korea Korean red ginseng Membrane Potentials - drug effects Panax - chemistry |
| title | In Vitro Candidacidal Action of Korean Red Ginseng Saponins against Candida albicans |
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