Application of enriched stable isotopes as tracers in biological systems: a critical review
The application of enriched stable isotopes of minerals and trace elements as tracers in biological systems is a rapidly growing research field that benefits from the many new developments in inorganic mass spectrometric instrumentation, primarily within inductively coupled plasma mass spectrometry...
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| Veröffentlicht in: | Analytical and bioanalytical chemistry 2008, Vol.390 (2), p.541-554 |
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| container_title | Analytical and bioanalytical chemistry |
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| creator | Stürup, Stefan Hansen, Helle Rüsz Gammelgaard, Bente |
| description | The application of enriched stable isotopes of minerals and trace elements as tracers in biological systems is a rapidly growing research field that benefits from the many new developments in inorganic mass spectrometric instrumentation, primarily within inductively coupled plasma mass spectrometry (ICP-MS) instrumentation, such as reaction/collision cell ICP-MS and multicollector ICP-MS with improved isotope ratio measurement and interference removal capabilities. Adaptation and refinement of radioisotope tracer experiment methodologies for enriched stable isotope experiments, and the development of new methodologies coupled with more advanced compartmental and mathematical models for the distribution of elements in living organisms has enabled a broader use of enriched stable isotope experiments in the biological sciences. This review discusses the current and future uses of enriched stable isotope experiments in biological systems. |
| doi_str_mv | 10.1007/s00216-007-1638-8 |
| format | Article |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Analytical Chemistry Animals Bioanalytical methods Biochemistry Biology - methods Cell Culture Techniques Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Ecosystem Food Science Humans Isotopes - analysis Isotopes - chemistry Isotopes - metabolism Laboratory Medicine Mass spectrometry/ICP-MS Monitoring/Environmental Analysis Research Design Review trace elements |
| title | Application of enriched stable isotopes as tracers in biological systems: a critical review |
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