Coccidioidal Meningitis

Residents of the area now occupied by the southwestern United States and northwestern Mexico have had to deal with coccidioidomycosis and complicating meningitis for >1500 years. The hundredth anniversary of the reporting of disseminated coccidioidomycosis has just passed. This year has the dubio...

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Veröffentlicht in:Clinical infectious diseases 2006-01, Vol.42 (1), p.103-107
Hauptverfasser: Goldstein, Ellie J. C., Johnson, Royce H., Einstein, Hans E.
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container_title Clinical infectious diseases
container_volume 42
creator Goldstein, Ellie J. C.
Johnson, Royce H.
Einstein, Hans E.
description Residents of the area now occupied by the southwestern United States and northwestern Mexico have had to deal with coccidioidomycosis and complicating meningitis for >1500 years. The hundredth anniversary of the reporting of disseminated coccidioidomycosis has just passed. This year has the dubious distinction of being the hundredth anniversary of the first description of coccidioidal meningitis. Although intrathecal amphotericin B began to be used for therapy 50 years ago, and although we have benefited from azole therapy for >10 years, the morbidity and mortality associated with this all-too-common disease remain unacceptably high. This review will endeavor to discuss the pathogenic, pathophysiologic, clinical, laboratory, radiologic, and therapeutic features of meningitis secondary to Coccidioides infection.
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subjects Arachnoiditis
Clinical Practice
Coccidioides
Coccidioidomycosis
Coccidioidomycosis - diagnosis
Coccidioidomycosis - drug therapy
Drug therapy
Epidemiology
Humans
Hydrocephalus
Infections
Medical treatment
Meningitis
Meningitis, Fungal - diagnosis
Meningitis, Fungal - drug therapy
Nervous system diseases
Pathology
Pregnancy complications
Risk factors
title Coccidioidal Meningitis
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