Biodegradable pH-Sensing Dendritic Nanoprobes for Near-Infrared Fluorescence Lifetime and Intensity Imaging
The overproduction of acidic byproducts is implicated in the development of numerous diseases, and there is currently great interest in developing contrast agents that can image acidic tissue in vivo. Here we report a biodegradable pH-sensing near-infrared (NIR) nanoprobe capable of providing both f...
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| Veröffentlicht in: | Journal of the American Chemical Society 2008-01, Vol.130 (2), p.444-445 |
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| container_end_page | 445 |
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| container_issue | 2 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 130 |
| creator | Almutairi, Adah Guillaudeu, Steven J Berezin, Mikhail Y Achilefu, Samuel Fréchet, Jean M. J |
| description | The overproduction of acidic byproducts is implicated in the development of numerous diseases, and there is currently great interest in developing contrast agents that can image acidic tissue in vivo. Here we report a biodegradable pH-sensing near-infrared (NIR) nanoprobe capable of providing both fluorescence intensity amplification and lifetime information. The pH-sensing NIR nanoprobe is synthesized, in six high yielding and scalable steps, and functions within the tissue transparency window. Both fluorescence intensity and lifetime provided complementary physiological (low pH) and molecular (released fluorophore binding to albumin) information, respectively. |
| doi_str_mv | 10.1021/ja078147e |
| format | Article |
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| ispartof | Journal of the American Chemical Society, 2008-01, Vol.130 (2), p.444-445 |
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| language | eng |
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| source | MEDLINE; ACS Publications |
| subjects | Acidosis - diagnosis Acids - analysis Animals Dendrimers - chemical synthesis Dendrimers - chemistry Fluorescence Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Humans Hydrogen-Ion Concentration Nanoparticles - chemistry Spectroscopy, Near-Infrared |
| title | Biodegradable pH-Sensing Dendritic Nanoprobes for Near-Infrared Fluorescence Lifetime and Intensity Imaging |
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