Axotomy-induced dopaminergic neurodegeneration is accompanied with c-Jun phosphorylation and activation transcription factor 3 expression

Accumulating evidence has shown that both phosphorylated c-Jun (pc-Jun) and activating transcription factor 3 (ATF3) were upregulated in a variety of tissue injuries and proposed to play an important role in cell death/survival. To elucidate the significance and functional role of these immediate-ea...

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Veröffentlicht in:	Experimental neurology 2008-01, Vol.209 (1), p.268-278
Hauptverfasser:	Song, Dae Y., Yang, Young C., Shin, Dong H., Sugama, Shuei, Kim, Yoon S., Lee, Bong H., Joh, Tong H., Cho, Byung P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated microglia Activating Transcription Factor 3 - biosynthesis Animals Antibodies, Monoclonal - metabolism ATF3 Axotomy Biological and medical sciences Cell Count Dopamine - physiology Dopaminergic neuron Drug toxicity and drugs side effects treatment Fluorescent Antibody Technique Fluorescent Dyes Genes, MHC Class II - genetics Image Processing, Computer-Assisted Immunohistochemistry Male Medical sciences MFB axotomy Microglia - physiology Nerve Degeneration - metabolism Nerve Degeneration - physiopathology Neurodegeneration Neurology Pc-Jun Phagocytosis - genetics Phagocytosis - physiology Pharmacology. Drug treatments Phosphorylation Proto-Oncogene Proteins c-jun - metabolism Rats Rats, Wistar Stilbamidines Substantia nigra Substantia Nigra - metabolism Toxicity: nervous system and muscle Tyrosine 3-Monooxygenase - metabolism
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