Gender Differences in Bone Mineral Density in Epilepsy
Summary Purpose: Bone accrual in adolescence is a major determinant of peak bone mass and risk of osteoporotic fractures later in life. Postmenopausal women are at highest risk, although, both men and premenopausal women with epilepsy experience adverse bone effects. We examined gender differences i...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 2008-01, Vol.49 (1), p.125-131 |
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| creator | Sheth, Raj D. Binkley, Neil Hermann, Bruce P. |
| description | Summary
Purpose: Bone accrual in adolescence is a major determinant of peak bone mass and risk of osteoporotic fractures later in life. Postmenopausal women are at highest risk, although, both men and premenopausal women with epilepsy experience adverse bone effects. We examined gender differences in bone density in epilepsy.
Methods: Cross‐sectional study examining age and gender‐specific z‐score total bone mineral density (z‐BMD) in 108 ambulatory children with epilepsy between 6 and 18 years of age (61 females 12.8 ± 3.6 years; 47 males 12.4 ± 3.1 years) compared to 35 healthy controls who were first‐degree cousins of patients (21 females 13.8 ± 2.5 years and 14 males 11.7 ± 2.5 years).
Results: Patients with epilepsy accrued lower z‐BMD compared to controls (0.27 ± 0.77 vs. 0.53 ± 1.1, p < 0.05), and were reduced for both females (0.23 ± 1.1 vs. 0.47 ± 0.76; p = 0.14, NS) and males (0.3 ± 1.1 vs. 0.8 ± 0.5; p = 0.11, NS). Increasing duration of epilepsy was associated with lower BMD in males (correlation coefficient = 0.06; p = 0.05). Males with ≥6 years of epilepsy experienced the lowest z‐BMD compared to controls (−0.89 ± 0.80 vs. 0.62 ± 0.80; p = 0.45). Fractures occurred in two females with epilepsy for ≥6 years and z‐BMD of −1.5 and −2.7.
Conclusions: BMD in both males and females with epilepsy is reduced. Young males with more chronic epilepsy (≥6 years) had the lowest BMD. Age at onset of epilepsy, growth trends, and hormonal differences may underlie these gender differences. Lower bone accrual in adolescence may contribute to increased fracture risk for both men and women with epilepsy. |
| doi_str_mv | 10.1111/j.1528-1167.2007.01253.x |
| format | Article |
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Purpose: Bone accrual in adolescence is a major determinant of peak bone mass and risk of osteoporotic fractures later in life. Postmenopausal women are at highest risk, although, both men and premenopausal women with epilepsy experience adverse bone effects. We examined gender differences in bone density in epilepsy.
Methods: Cross‐sectional study examining age and gender‐specific z‐score total bone mineral density (z‐BMD) in 108 ambulatory children with epilepsy between 6 and 18 years of age (61 females 12.8 ± 3.6 years; 47 males 12.4 ± 3.1 years) compared to 35 healthy controls who were first‐degree cousins of patients (21 females 13.8 ± 2.5 years and 14 males 11.7 ± 2.5 years).
Results: Patients with epilepsy accrued lower z‐BMD compared to controls (0.27 ± 0.77 vs. 0.53 ± 1.1, p < 0.05), and were reduced for both females (0.23 ± 1.1 vs. 0.47 ± 0.76; p = 0.14, NS) and males (0.3 ± 1.1 vs. 0.8 ± 0.5; p = 0.11, NS). Increasing duration of epilepsy was associated with lower BMD in males (correlation coefficient = 0.06; p = 0.05). Males with ≥6 years of epilepsy experienced the lowest z‐BMD compared to controls (−0.89 ± 0.80 vs. 0.62 ± 0.80; p = 0.45). Fractures occurred in two females with epilepsy for ≥6 years and z‐BMD of −1.5 and −2.7.
Conclusions: BMD in both males and females with epilepsy is reduced. Young males with more chronic epilepsy (≥6 years) had the lowest BMD. Age at onset of epilepsy, growth trends, and hormonal differences may underlie these gender differences. Lower bone accrual in adolescence may contribute to increased fracture risk for both men and women with epilepsy.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/j.1528-1167.2007.01253.x</identifier><identifier>PMID: 17683508</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Absorptiometry, Photon - statistics & numerical data ; Adolescent ; Age Factors ; Anticonvulsants - therapeutic use ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Bone ; Bone Density - physiology ; Bone Diseases, Metabolic - diagnosis ; Bone Diseases, Metabolic - epidemiology ; Bone mineral density ; Calcium, Dietary - administration & dosage ; Child ; Comorbidity ; Control Groups ; Cross-Sectional Studies ; Epilepsy - diagnosis ; Epilepsy - drug therapy ; Epilepsy - epidemiology ; Female ; Fractures ; Gender ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropharmacology ; Pediatric epilepsy ; Pharmacology. Drug treatments ; Risk Factors ; Sex Factors</subject><ispartof>Epilepsia (Copenhagen), 2008-01, Vol.49 (1), p.125-131</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4633-a9db6de85d608e1856e200f65be61450cd447790cf96dea6cc8a205d5f9adcd03</citedby><cites>FETCH-LOGICAL-c4633-a9db6de85d608e1856e200f65be61450cd447790cf96dea6cc8a205d5f9adcd03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1528-1167.2007.01253.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1528-1167.2007.01253.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27922,27923,45572,45573,46407,46831</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20031112$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17683508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sheth, Raj D.</creatorcontrib><creatorcontrib>Binkley, Neil</creatorcontrib><creatorcontrib>Hermann, Bruce P.</creatorcontrib><title>Gender Differences in Bone Mineral Density in Epilepsy</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Summary
Purpose: Bone accrual in adolescence is a major determinant of peak bone mass and risk of osteoporotic fractures later in life. Postmenopausal women are at highest risk, although, both men and premenopausal women with epilepsy experience adverse bone effects. We examined gender differences in bone density in epilepsy.
Methods: Cross‐sectional study examining age and gender‐specific z‐score total bone mineral density (z‐BMD) in 108 ambulatory children with epilepsy between 6 and 18 years of age (61 females 12.8 ± 3.6 years; 47 males 12.4 ± 3.1 years) compared to 35 healthy controls who were first‐degree cousins of patients (21 females 13.8 ± 2.5 years and 14 males 11.7 ± 2.5 years).
Results: Patients with epilepsy accrued lower z‐BMD compared to controls (0.27 ± 0.77 vs. 0.53 ± 1.1, p < 0.05), and were reduced for both females (0.23 ± 1.1 vs. 0.47 ± 0.76; p = 0.14, NS) and males (0.3 ± 1.1 vs. 0.8 ± 0.5; p = 0.11, NS). Increasing duration of epilepsy was associated with lower BMD in males (correlation coefficient = 0.06; p = 0.05). Males with ≥6 years of epilepsy experienced the lowest z‐BMD compared to controls (−0.89 ± 0.80 vs. 0.62 ± 0.80; p = 0.45). Fractures occurred in two females with epilepsy for ≥6 years and z‐BMD of −1.5 and −2.7.
Conclusions: BMD in both males and females with epilepsy is reduced. Young males with more chronic epilepsy (≥6 years) had the lowest BMD. Age at onset of epilepsy, growth trends, and hormonal differences may underlie these gender differences. Lower bone accrual in adolescence may contribute to increased fracture risk for both men and women with epilepsy.</description><subject>Absorptiometry, Photon - statistics & numerical data</subject><subject>Adolescent</subject><subject>Age Factors</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Bone</subject><subject>Bone Density - physiology</subject><subject>Bone Diseases, Metabolic - diagnosis</subject><subject>Bone Diseases, Metabolic - epidemiology</subject><subject>Bone mineral density</subject><subject>Calcium, Dietary - administration & dosage</subject><subject>Child</subject><subject>Comorbidity</subject><subject>Control Groups</subject><subject>Cross-Sectional Studies</subject><subject>Epilepsy - diagnosis</subject><subject>Epilepsy - drug therapy</subject><subject>Epilepsy - epidemiology</subject><subject>Female</subject><subject>Fractures</subject><subject>Gender</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Pediatric epilepsy</subject><subject>Pharmacology. Drug treatments</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkDtPwzAQgC0EouXxF1AW2BLOce04AwO0pVQqggFmy7UvUqo0CXYr2n-PQ6Oy4uWsu-8e-giJKCQ0vPtVQnkqY0pFlqQAWQI05SzZnZDhsXBKhgCUxTmXMCAX3q8gkCJj52RAMyEZBzkkYoa1RRdNyqJAh7VBH5V19NTUGL2WNTpdRROsfbnZd_lpW1bY-v0VOSt05fG6j5fk83n6MX6JF2-z-fhxEZuRYCzWuV0Ki5JbARKp5ALDuYXgSxR0xMHY0SjLcjBFHjAtjJE6BW55kWtrLLBLcneY27rma4t-o9alN1hVusZm61UGNE9TYAGUB9C4xnuHhWpdudZuryiozplaqU6N6tSozpn6daZ2ofWm37FdrtH-NfaSAnDbA9obXRVO16b0Ry4MY2FBGriHA_cdJO3_fYCavs-7H_sBu-WF-A</recordid><startdate>200801</startdate><enddate>200801</enddate><creator>Sheth, Raj D.</creator><creator>Binkley, Neil</creator><creator>Hermann, Bruce P.</creator><general>Blackwell Publishing Inc</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200801</creationdate><title>Gender Differences in Bone Mineral Density in Epilepsy</title><author>Sheth, Raj D. ; Binkley, Neil ; Hermann, Bruce P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4633-a9db6de85d608e1856e200f65be61450cd447790cf96dea6cc8a205d5f9adcd03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Absorptiometry, Photon - statistics & numerical data</topic><topic>Adolescent</topic><topic>Age Factors</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Bone</topic><topic>Bone Density - physiology</topic><topic>Bone Diseases, Metabolic - diagnosis</topic><topic>Bone Diseases, Metabolic - epidemiology</topic><topic>Bone mineral density</topic><topic>Calcium, Dietary - administration & dosage</topic><topic>Child</topic><topic>Comorbidity</topic><topic>Control Groups</topic><topic>Cross-Sectional Studies</topic><topic>Epilepsy - diagnosis</topic><topic>Epilepsy - drug therapy</topic><topic>Epilepsy - epidemiology</topic><topic>Female</topic><topic>Fractures</topic><topic>Gender</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Pediatric epilepsy</topic><topic>Pharmacology. Drug treatments</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sheth, Raj D.</creatorcontrib><creatorcontrib>Binkley, Neil</creatorcontrib><creatorcontrib>Hermann, Bruce P.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sheth, Raj D.</au><au>Binkley, Neil</au><au>Hermann, Bruce P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender Differences in Bone Mineral Density in Epilepsy</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2008-01</date><risdate>2008</risdate><volume>49</volume><issue>1</issue><spage>125</spage><epage>131</epage><pages>125-131</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Summary
Purpose: Bone accrual in adolescence is a major determinant of peak bone mass and risk of osteoporotic fractures later in life. Postmenopausal women are at highest risk, although, both men and premenopausal women with epilepsy experience adverse bone effects. We examined gender differences in bone density in epilepsy.
Methods: Cross‐sectional study examining age and gender‐specific z‐score total bone mineral density (z‐BMD) in 108 ambulatory children with epilepsy between 6 and 18 years of age (61 females 12.8 ± 3.6 years; 47 males 12.4 ± 3.1 years) compared to 35 healthy controls who were first‐degree cousins of patients (21 females 13.8 ± 2.5 years and 14 males 11.7 ± 2.5 years).
Results: Patients with epilepsy accrued lower z‐BMD compared to controls (0.27 ± 0.77 vs. 0.53 ± 1.1, p < 0.05), and were reduced for both females (0.23 ± 1.1 vs. 0.47 ± 0.76; p = 0.14, NS) and males (0.3 ± 1.1 vs. 0.8 ± 0.5; p = 0.11, NS). Increasing duration of epilepsy was associated with lower BMD in males (correlation coefficient = 0.06; p = 0.05). Males with ≥6 years of epilepsy experienced the lowest z‐BMD compared to controls (−0.89 ± 0.80 vs. 0.62 ± 0.80; p = 0.45). Fractures occurred in two females with epilepsy for ≥6 years and z‐BMD of −1.5 and −2.7.
Conclusions: BMD in both males and females with epilepsy is reduced. Young males with more chronic epilepsy (≥6 years) had the lowest BMD. Age at onset of epilepsy, growth trends, and hormonal differences may underlie these gender differences. Lower bone accrual in adolescence may contribute to increased fracture risk for both men and women with epilepsy.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17683508</pmid><doi>10.1111/j.1528-1167.2007.01253.x</doi><tpages>7</tpages></addata></record> |
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| ispartof | Epilepsia (Copenhagen), 2008-01, Vol.49 (1), p.125-131 |
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| source | IngentaConnect Journals (Open Access); MEDLINE; Wiley Online Library; Wiley Free Archive; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Absorptiometry, Photon - statistics & numerical data Adolescent Age Factors Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Bone Bone Density - physiology Bone Diseases, Metabolic - diagnosis Bone Diseases, Metabolic - epidemiology Bone mineral density Calcium, Dietary - administration & dosage Child Comorbidity Control Groups Cross-Sectional Studies Epilepsy - diagnosis Epilepsy - drug therapy Epilepsy - epidemiology Female Fractures Gender Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pediatric epilepsy Pharmacology. Drug treatments Risk Factors Sex Factors |
| title | Gender Differences in Bone Mineral Density in Epilepsy |
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