receptor that mediates the post-mating switch in Drosophila reproductive behaviour
Mating in many species induces a dramatic switch in female reproductive behaviour. In most insects, this switch is triggered by factors present in the male's seminal fluid. How these factors exert such profound effects in females is unknown. Here we identify a receptor for the Drosophila melano...
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| Veröffentlicht in: | Nature 2008-01, Vol.451 (7174), p.33-37 |
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| creator | Yapici, N Kim, Y.J Ribeiro, C Dickson, B.J |
| description | Mating in many species induces a dramatic switch in female reproductive behaviour. In most insects, this switch is triggered by factors present in the male's seminal fluid. How these factors exert such profound effects in females is unknown. Here we identify a receptor for the Drosophila melanogaster sex peptide (SP, also known as Acp70A), the primary trigger of post-mating responses in this species. Females that lack the sex peptide receptor (SPR, also known as CG16752), either entirely or only in the nervous system, fail to respond to SP and continue to show virgin behaviours even after mating. SPR is expressed in the female's reproductive tract and central nervous system. The behavioural functions of SPR map to the subset of neurons that also express the fruitless gene, a key determinant of sex-specific reproductive behaviour. SPR is highly conserved across insects, opening up the prospect of new strategies to control the reproductive and host-seeking behaviours of agricultural pests and human disease vectors. |
| doi_str_mv | 10.1038/nature06483 |
| format | Article |
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In most insects, this switch is triggered by factors present in the male's seminal fluid. How these factors exert such profound effects in females is unknown. Here we identify a receptor for the Drosophila melanogaster sex peptide (SP, also known as Acp70A), the primary trigger of post-mating responses in this species. Females that lack the sex peptide receptor (SPR, also known as CG16752), either entirely or only in the nervous system, fail to respond to SP and continue to show virgin behaviours even after mating. SPR is expressed in the female's reproductive tract and central nervous system. The behavioural functions of SPR map to the subset of neurons that also express the fruitless gene, a key determinant of sex-specific reproductive behaviour. SPR is highly conserved across insects, opening up the prospect of new strategies to control the reproductive and host-seeking behaviours of agricultural pests and human disease vectors.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>EISSN: 1476-4679</identifier><identifier>DOI: 10.1038/nature06483</identifier><identifier>PMID: 18066048</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Biological and medical sciences ; Cell receptors ; Cell structures and functions ; central nervous system ; Central Nervous System - metabolism ; Conserved Sequence ; copulation ; Copulation - physiology ; Drosophila melanogaster ; Drosophila melanogaster - cytology ; Drosophila melanogaster - physiology ; Drosophila Proteins - chemistry ; Drosophila Proteins - deficiency ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Female ; female reproductive system ; females ; Fundamental and applied biological sciences. Psychology ; Genitalia, Female - metabolism ; Humanities and Social Sciences ; Male ; Miscellaneous ; Molecular and cellular biology ; multidisciplinary ; Nerve Tissue Proteins - metabolism ; neurons ; Neurons - metabolism ; peptides ; Peptides - chemistry ; Peptides - deficiency ; Peptides - genetics ; Peptides - metabolism ; receptors ; Receptors, Peptide ; reproductive behavior ; Science ; Science (multidisciplinary) ; sex peptide receptor ; Sexual Behavior, Animal - physiology ; Substrate Specificity ; Transcription Factors - metabolism</subject><ispartof>Nature, 2008-01, Vol.451 (7174), p.33-37</ispartof><rights>Springer Nature Limited 2007</rights><rights>2008 INIST-CNRS</rights><rights>COPYRIGHT 2008 Nature Publishing Group</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-f27954b73366ac59cd83ad81e9175853eb463e1dbf3d159ef9a80d0d54198e563</citedby><cites>FETCH-LOGICAL-c573t-f27954b73366ac59cd83ad81e9175853eb463e1dbf3d159ef9a80d0d54198e563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20176110$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18066048$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yapici, N</creatorcontrib><creatorcontrib>Kim, Y.J</creatorcontrib><creatorcontrib>Ribeiro, C</creatorcontrib><creatorcontrib>Dickson, B.J</creatorcontrib><title>receptor that mediates the post-mating switch in Drosophila reproductive behaviour</title><title>Nature</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Mating in many species induces a dramatic switch in female reproductive behaviour. In most insects, this switch is triggered by factors present in the male's seminal fluid. How these factors exert such profound effects in females is unknown. Here we identify a receptor for the Drosophila melanogaster sex peptide (SP, also known as Acp70A), the primary trigger of post-mating responses in this species. Females that lack the sex peptide receptor (SPR, also known as CG16752), either entirely or only in the nervous system, fail to respond to SP and continue to show virgin behaviours even after mating. SPR is expressed in the female's reproductive tract and central nervous system. The behavioural functions of SPR map to the subset of neurons that also express the fruitless gene, a key determinant of sex-specific reproductive behaviour. SPR is highly conserved across insects, opening up the prospect of new strategies to control the reproductive and host-seeking behaviours of agricultural pests and human disease vectors.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>central nervous system</subject><subject>Central Nervous System - metabolism</subject><subject>Conserved Sequence</subject><subject>copulation</subject><subject>Copulation - physiology</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - cytology</subject><subject>Drosophila melanogaster - physiology</subject><subject>Drosophila Proteins - chemistry</subject><subject>Drosophila Proteins - deficiency</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Female</subject><subject>female reproductive system</subject><subject>females</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genitalia, Female - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Male</subject><subject>Miscellaneous</subject><subject>Molecular and cellular biology</subject><subject>multidisciplinary</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>neurons</subject><subject>Neurons - metabolism</subject><subject>peptides</subject><subject>Peptides - chemistry</subject><subject>Peptides - deficiency</subject><subject>Peptides - genetics</subject><subject>Peptides - metabolism</subject><subject>receptors</subject><subject>Receptors, Peptide</subject><subject>reproductive behavior</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>sex peptide receptor</subject><subject>Sexual Behavior, Animal - physiology</subject><subject>Substrate Specificity</subject><subject>Transcription Factors - metabolism</subject><issn>0028-0836</issn><issn>1476-4687</issn><issn>1476-4679</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0s1rFDEUAPAgil1XT951KlgQnZpMMvk4llq1UBBaew6ZzJvZlPlqkqn63xuZpXZhRXIISX55L-Q9hF4SfEwwlR8HE2cPmDNJH6EVYYLnjEvxGK0wLmSOJeUH6FkINxjjkgj2FB0QiTnHTK7QpQcLUxx9FjcmZj3UzkQIaQXZNIaY9ya6oc3CDxftJnND9smPYZw2rjOZh8mP9Wyju4Osgo25c-Psn6MnjekCvNjOa3T9-ez76df84tuX89OTi9yWgsa8KYQqWSUo5dzYUtlaUlNLAoqIUpYUKsYpkLpqaE1KBY0yEte4LhlREkpO1-hoiZsecTtDiLp3wULXmQHGOWiBiSqwYP-FBVaC8EIkmC-wNR1oNzRj9Ma2MIA33ThA49L2CZFKMEWpTP7NHm8nd6sfouM9KI0aemf3Rn23cyGZCD9ja-YQ9PnV5a59v1ibqhI8NHryrjf-lyZY_-kO_aA7kn61_Yi5SpX-a7ftkMDbLTDBmq7xZrAu3LsCE8FJCrtGHxYX0tHQgtc3qfBDqvY_8h4ufNm8j7drXi-mMaM2rU9pr69SQoqxVAXjnP4G5x_k7w</recordid><startdate>20080103</startdate><enddate>20080103</enddate><creator>Yapici, N</creator><creator>Kim, Y.J</creator><creator>Ribeiro, C</creator><creator>Dickson, B.J</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080103</creationdate><title>receptor that mediates the post-mating switch in Drosophila reproductive behaviour</title><author>Yapici, N ; Kim, Y.J ; Ribeiro, C ; Dickson, B.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-f27954b73366ac59cd83ad81e9175853eb463e1dbf3d159ef9a80d0d54198e563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>central nervous system</topic><topic>Central Nervous System - metabolism</topic><topic>Conserved Sequence</topic><topic>copulation</topic><topic>Copulation - physiology</topic><topic>Drosophila melanogaster</topic><topic>Drosophila melanogaster - cytology</topic><topic>Drosophila melanogaster - physiology</topic><topic>Drosophila Proteins - chemistry</topic><topic>Drosophila Proteins - deficiency</topic><topic>Drosophila Proteins - genetics</topic><topic>Drosophila Proteins - metabolism</topic><topic>Female</topic><topic>female reproductive system</topic><topic>females</topic><topic>Fundamental and applied biological sciences. 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In most insects, this switch is triggered by factors present in the male's seminal fluid. How these factors exert such profound effects in females is unknown. Here we identify a receptor for the Drosophila melanogaster sex peptide (SP, also known as Acp70A), the primary trigger of post-mating responses in this species. Females that lack the sex peptide receptor (SPR, also known as CG16752), either entirely or only in the nervous system, fail to respond to SP and continue to show virgin behaviours even after mating. SPR is expressed in the female's reproductive tract and central nervous system. The behavioural functions of SPR map to the subset of neurons that also express the fruitless gene, a key determinant of sex-specific reproductive behaviour. 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| subjects | Animals Biological and medical sciences Cell receptors Cell structures and functions central nervous system Central Nervous System - metabolism Conserved Sequence copulation Copulation - physiology Drosophila melanogaster Drosophila melanogaster - cytology Drosophila melanogaster - physiology Drosophila Proteins - chemistry Drosophila Proteins - deficiency Drosophila Proteins - genetics Drosophila Proteins - metabolism Female female reproductive system females Fundamental and applied biological sciences. Psychology Genitalia, Female - metabolism Humanities and Social Sciences Male Miscellaneous Molecular and cellular biology multidisciplinary Nerve Tissue Proteins - metabolism neurons Neurons - metabolism peptides Peptides - chemistry Peptides - deficiency Peptides - genetics Peptides - metabolism receptors Receptors, Peptide reproductive behavior Science Science (multidisciplinary) sex peptide receptor Sexual Behavior, Animal - physiology Substrate Specificity Transcription Factors - metabolism |
| title | receptor that mediates the post-mating switch in Drosophila reproductive behaviour |
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