DNA histochemical analysis in oral squamous cell carcinoma
Recent years have witnessed an increasing emphasis on the role of nuclear DNA and its application in experimental pathological diagnosis to predict prognosis and management of certain neoplasm. to establish objective criteria for the degree of differentiation and histochemical quantitative of nuclea...
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| Veröffentlicht in: | Archives of oral biology 2006, Vol.51 (1), p.64-68 |
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| container_title | Archives of oral biology |
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| creator | Al-Azzawi, Lehadh M. Al-Talabani, Nazar G. Al-Salihi, Anam R. |
| description | Recent years have witnessed an increasing emphasis on the role of nuclear DNA and its application in experimental pathological diagnosis to predict prognosis and management of certain neoplasm.
to establish objective criteria for the degree of differentiation and histochemical quantitative of nuclear DNA of oral squamous cell carcinoma (OSCC) using microspectrophotometric analysis.
The study was conducted on histologic materials from patient with OSCC. Two histological grading systems were used; Broder's and invasive front grading system were recorded. Microspectrophotometry was applied on Feulgen-stained sections to determine the quality of tumour nuclear DNA content in two different histological grading systems of OSCC.
Nuclear DNA content increased significantly with decreasing tissue differentiation as well with increasing tumour size.
The grading system and DNA content provides more objective and accurate criteria which relate the morphologic finding to biologic activity and growth patterns of oral cancer as compared to histologic differentiation alone. |
| doi_str_mv | 10.1016/j.archoralbio.2005.05.006 |
| format | Article |
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to establish objective criteria for the degree of differentiation and histochemical quantitative of nuclear DNA of oral squamous cell carcinoma (OSCC) using microspectrophotometric analysis.
The study was conducted on histologic materials from patient with OSCC. Two histological grading systems were used; Broder's and invasive front grading system were recorded. Microspectrophotometry was applied on Feulgen-stained sections to determine the quality of tumour nuclear DNA content in two different histological grading systems of OSCC.
Nuclear DNA content increased significantly with decreasing tissue differentiation as well with increasing tumour size.
The grading system and DNA content provides more objective and accurate criteria which relate the morphologic finding to biologic activity and growth patterns of oral cancer as compared to histologic differentiation alone.</description><identifier>ISSN: 0003-9969</identifier><identifier>EISSN: 1879-1506</identifier><identifier>DOI: 10.1016/j.archoralbio.2005.05.006</identifier><identifier>PMID: 16055079</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aneuploidy ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - pathology ; Dentistry ; DNA, Neoplasm - analysis ; Humans ; Image Cytometry ; Mouth Neoplasms - genetics ; Mouth Neoplasms - pathology ; Oral squamous cell carcinoma ; OSCC ; Predictive Value of Tests ; Staining and Labeling</subject><ispartof>Archives of oral biology, 2006, Vol.51 (1), p.64-68</ispartof><rights>2005 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-6c1f3b13137d58849a029bf9b526ef0c7281286d55ddba74258b454f628664e23</citedby><cites>FETCH-LOGICAL-c375t-6c1f3b13137d58849a029bf9b526ef0c7281286d55ddba74258b454f628664e23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.archoralbio.2005.05.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,4025,27928,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16055079$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Azzawi, Lehadh M.</creatorcontrib><creatorcontrib>Al-Talabani, Nazar G.</creatorcontrib><creatorcontrib>Al-Salihi, Anam R.</creatorcontrib><title>DNA histochemical analysis in oral squamous cell carcinoma</title><title>Archives of oral biology</title><addtitle>Arch Oral Biol</addtitle><description>Recent years have witnessed an increasing emphasis on the role of nuclear DNA and its application in experimental pathological diagnosis to predict prognosis and management of certain neoplasm.
to establish objective criteria for the degree of differentiation and histochemical quantitative of nuclear DNA of oral squamous cell carcinoma (OSCC) using microspectrophotometric analysis.
The study was conducted on histologic materials from patient with OSCC. Two histological grading systems were used; Broder's and invasive front grading system were recorded. Microspectrophotometry was applied on Feulgen-stained sections to determine the quality of tumour nuclear DNA content in two different histological grading systems of OSCC.
Nuclear DNA content increased significantly with decreasing tissue differentiation as well with increasing tumour size.
The grading system and DNA content provides more objective and accurate criteria which relate the morphologic finding to biologic activity and growth patterns of oral cancer as compared to histologic differentiation alone.</description><subject>Aneuploidy</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Dentistry</subject><subject>DNA, Neoplasm - analysis</subject><subject>Humans</subject><subject>Image Cytometry</subject><subject>Mouth Neoplasms - genetics</subject><subject>Mouth Neoplasms - pathology</subject><subject>Oral squamous cell carcinoma</subject><subject>OSCC</subject><subject>Predictive Value of Tests</subject><subject>Staining and Labeling</subject><issn>0003-9969</issn><issn>1879-1506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUE1LxDAQDaK46-pfkHrx1jpJm7TxJusnLHrRc0iTlM3SNrtJK-y_N2UX9Cg8GGZ4897MQ-gGQ4YBs7tNJr1aOy_b2rqMANBsArATNMdVyVNMgZ2iOQDkKeeMz9BFCJvYUsbwOZphBpRCyefo_vH9IVnbMDi1Np1Vsk1kL9t9sCGxfTJ5JGE3ys6NIVGmbRMVvW3vOnmJzhrZBnN1rAv09fz0uXxNVx8vb8uHVarykg4pU7jJa5zjvNS0qgougfC64TUlzDSgSlJhUjFNqda1LAtCq7qgRcPikBWG5At0e9DdercbTRhEZ8N0iuxNvEqUgDnmUX-B-IGovAvBm0Zsve2k3wsMYgpObMSf4MQUnJgALO5eH03GujP6d_OYVCQsDwQTX_22xougrOmV0dYbNQjt7D9sfgAZ3IPD</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>Al-Azzawi, Lehadh M.</creator><creator>Al-Talabani, Nazar G.</creator><creator>Al-Salihi, Anam R.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2006</creationdate><title>DNA histochemical analysis in oral squamous cell carcinoma</title><author>Al-Azzawi, Lehadh M. ; Al-Talabani, Nazar G. ; Al-Salihi, Anam R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-6c1f3b13137d58849a029bf9b526ef0c7281286d55ddba74258b454f628664e23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aneuploidy</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Dentistry</topic><topic>DNA, Neoplasm - analysis</topic><topic>Humans</topic><topic>Image Cytometry</topic><topic>Mouth Neoplasms - genetics</topic><topic>Mouth Neoplasms - pathology</topic><topic>Oral squamous cell carcinoma</topic><topic>OSCC</topic><topic>Predictive Value of Tests</topic><topic>Staining and Labeling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Azzawi, Lehadh M.</creatorcontrib><creatorcontrib>Al-Talabani, Nazar G.</creatorcontrib><creatorcontrib>Al-Salihi, Anam R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of oral biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Azzawi, Lehadh M.</au><au>Al-Talabani, Nazar G.</au><au>Al-Salihi, Anam R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA histochemical analysis in oral squamous cell carcinoma</atitle><jtitle>Archives of oral biology</jtitle><addtitle>Arch Oral Biol</addtitle><date>2006</date><risdate>2006</risdate><volume>51</volume><issue>1</issue><spage>64</spage><epage>68</epage><pages>64-68</pages><issn>0003-9969</issn><eissn>1879-1506</eissn><abstract>Recent years have witnessed an increasing emphasis on the role of nuclear DNA and its application in experimental pathological diagnosis to predict prognosis and management of certain neoplasm.
to establish objective criteria for the degree of differentiation and histochemical quantitative of nuclear DNA of oral squamous cell carcinoma (OSCC) using microspectrophotometric analysis.
The study was conducted on histologic materials from patient with OSCC. Two histological grading systems were used; Broder's and invasive front grading system were recorded. Microspectrophotometry was applied on Feulgen-stained sections to determine the quality of tumour nuclear DNA content in two different histological grading systems of OSCC.
Nuclear DNA content increased significantly with decreasing tissue differentiation as well with increasing tumour size.
The grading system and DNA content provides more objective and accurate criteria which relate the morphologic finding to biologic activity and growth patterns of oral cancer as compared to histologic differentiation alone.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>16055079</pmid><doi>10.1016/j.archoralbio.2005.05.006</doi><tpages>5</tpages></addata></record> |
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| ispartof | Archives of oral biology, 2006, Vol.51 (1), p.64-68 |
| issn | 0003-9969 1879-1506 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aneuploidy Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Dentistry DNA, Neoplasm - analysis Humans Image Cytometry Mouth Neoplasms - genetics Mouth Neoplasms - pathology Oral squamous cell carcinoma OSCC Predictive Value of Tests Staining and Labeling |
| title | DNA histochemical analysis in oral squamous cell carcinoma |
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