Prolongation of Composite Tissue Allograft Survival by Immature Recipient Dendritic Cells Pulsed with Donor Antigen and Transient Low-Dose Immunosuppression

Composite tissue allograft transplantation is limited by risks of long-term immunosuppression. The authors investigated whether short-term immunosuppression combined with recipient immature dendritic cells pulsed with donor antigens promotes composite tissue allograft survival. Orthotopic hind-limb...

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Veröffentlicht in:	Plastic and reconstructive surgery (1963) 2008-01, Vol.121 (1), p.37-49
Hauptverfasser:	Sacks, Justin M., Kuo, Yur-Ren, Taieb, Aurele, Breitinger, Jeremy, Nguyen, Vu T., Thomson, Angus W., Feili-Hariri, Maryam, Lee, W P. Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - immunology Antilymphocyte Serum - pharmacology Biological and medical sciences Cyclosporine - pharmacology Dendritic Cells - immunology Disease Models, Animal Graft Survival - drug effects Graft Survival - immunology Immunosuppressive Agents - pharmacology Male Medical sciences Rats Rats, Inbred Lew Rats, Inbred WF Spleen - cytology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue Transplantation - physiology Transplantation, Homologous - immunology
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