Deguelin Represses Both the Expression of Nucleophosmin and some Nucleoporins: Nup88 and Nup214 in Jurkat Cells

Since the first report about cytoplasmic nucleophosmin (NPM) in acute myelogenous leukemia with a normal karyotype was announced, the shuttling activity of NPM and its proper subcellular localization have drawn many attentions. Mechanisms that regulate nucleocytoplasmic transport of proteins may pro...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2008/01/01, Vol.31(1), pp.27-32
Hauptverfasser:	Shu, Wenxiu, Chen, Yan, Wu, Qing, Li, Rui, Cui, Guohui
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Antineoplastic Agents - pharmacology apoptosis Apoptosis - drug effects Cell Proliferation - drug effects deguelin Dose-Response Relationship, Drug Down-Regulation Humans Jurkat Cells leukemia Leukemia - drug therapy Nuclear Pore Complex Proteins - antagonists & inhibitors Nuclear Pore Complex Proteins - genetics Nuclear Pore Complex Proteins - metabolism nucleophosmin nucleoporin Rotenone - analogs & derivatives Rotenone - pharmacology
Online-Zugang:	Volltext
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