Testicular germ cell tumors exhibit evidence of hormone dependence

The aim of this investigation was to test the hypothesis that testicular germ cell tumors (TGCTs) are hormone‐dependent cancers. Human TGCT cells were implanted in the left testis of male severe combined immunodeficient mice receiving either no treatment or hormone manipulation treatment [blockade o...

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Veröffentlicht in:	International journal of cancer 2006-01, Vol.118 (1), p.98-102
Hauptverfasser:	Douglas, Meaghan L., Richardson, Michelle M., Nicol, David L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal tumors. Experimental tumors Animals Antineoplastic Agents, Hormonal - pharmacology Aromatase - biosynthesis Biological and medical sciences Estrogens - biosynthesis Experimental tumors, general aspects Gene Expression Profiling gonadotropin‐releasing hormone Humans Leuprolide - pharmacology Male Medical sciences Mice Mice, SCID Neoplasms, Germ Cell and Embryonal - physiopathology orthotopic xenograft model Receptors, FSH - biosynthesis Receptors, LH - biosynthesis Reverse Transcriptase Polymerase Chain Reaction testicular cancer Testicular Neoplasms - physiopathology Testosterone - physiology Transplantation, Heterologous Tumors
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