Features of trinucleotide repeat instability in vivo
Unstable repeats are associated with various types of cancer and have been implicated in more than 40 neurode-generative disorders. Trinucleotide repeats are located in non-coding and coding regions of the genome. Studies of bacteria, yeast, mice and man have helped to unravel some features of the m...
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| Veröffentlicht in: | Cell research 2008, Vol.18 (1), p.198-213 |
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| creator | Kovtun, Irina V McMurray, Cynthia T |
| description | Unstable repeats are associated with various types of cancer and have been implicated in more than 40 neurode-generative disorders. Trinucleotide repeats are located in non-coding and coding regions of the genome. Studies of bacteria, yeast, mice and man have helped to unravel some features of the mechanism of trinucleotide expansion. Looped DNA structures comprising trinucleotide repeats are processed during replication and/or repair to generate deletions or expansions. Most in vivo data are consistent with a model in which expansion and deletion occur by different mechanisms. In mammals, microsatellite instability is complex and appears to be influenced by genetic, epigenetic and developmental factors. |
| doi_str_mv | 10.1038/cr.2008.5 |
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Trinucleotide repeats are located in non-coding and coding regions of the genome. Studies of bacteria, yeast, mice and man have helped to unravel some features of the mechanism of trinucleotide expansion. Looped DNA structures comprising trinucleotide repeats are processed during replication and/or repair to generate deletions or expansions. Most in vivo data are consistent with a model in which expansion and deletion occur by different mechanisms. 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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Animals Base Sequence Biomedical and Life Sciences Cell Biology Chromatin - physiology Deoxyribonucleic acid DNA Gene Frequency Genetic Diseases, Inborn - epidemiology Genetic Diseases, Inborn - genetics Humans Incidence Life Sciences Mammals Microsatellite Instability Models, Biological Molecular Sequence Data Nucleic Acid Conformation Regulatory Elements, Transcriptional - physiology review Trinucleotide Repeats - genetics Trinucleotide Repeats - physiology Yeasts 三核苷酸 不稳定性 生物结构 |
| title | Features of trinucleotide repeat instability in vivo |
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