Troponin C/calmodulin chimeras as erythrocyte plasma membrane Ca2+-ATPase activators

Calmodulin (CaM) and troponin C (TnC) are EF-hand proteins that play fundamentally different roles in animal physiology. TnC has a very low affinity for the plasma membrane Ca2+-ATPase and is a poor substitute for CaM in increasing the enzyme's affinity for Ca2+ and the rate of ATP hydrolysis....

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2006-02, Vol.38 (2), p.209-221
Hauptverfasser:	Fidalgo da Silva, Elizabeth, Freire, Mônica M, Barrabin, Hector, Sorenson, Martha M, Tikunova, Svetlana, Johnson, J David, Chandra, Murali, Pearlstone, Joyce R, Scofano, Helena M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Brain - metabolism Calcium - metabolism Calcium-Transporting ATPases - genetics Calcium-Transporting ATPases - metabolism Calmodulin - genetics Calmodulin - metabolism Cattle Chickens Enzyme Activation Erythrocyte Membrane - metabolism Models, Molecular Molecular Sequence Data Muscle, Skeletal - metabolism Protein Conformation Protein Structure, Tertiary Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Sequence Alignment Signal Transduction - physiology Swine Troponin C - genetics Troponin C - metabolism
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