The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each passage through the cell cycle. It is therefore not surprising that metabolic activities in proliferating cells are fundamentally different from those in nonproliferating c...
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| Veröffentlicht in: | Cell metabolism 2008-01, Vol.7 (1), p.11-20 |
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| creator | DeBerardinis, Ralph J. Lum, Julian J. Hatzivassiliou, Georgia Thompson, Craig B. |
| description | Cell proliferation requires nutrients, energy, and biosynthetic activity to duplicate all macromolecular components during each passage through the cell cycle. It is therefore not surprising that metabolic activities in proliferating cells are fundamentally different from those in nonproliferating cells. This review examines the idea that several core fluxes, including aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis, form a stereotyped platform supporting proliferation of diverse cell types. We also consider regulation of these fluxes by cellular mediators of signal transduction and gene expression, including the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR system, hypoxia-inducible factor 1 (HIF-1), and Myc, during physiologic cell proliferation and tumorigenesis. |
| doi_str_mv | 10.1016/j.cmet.2007.10.002 |
| format | Article |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Cell Proliferation Humans Hypoxia-Inducible Factor 1 - metabolism Models, Biological Neoplasms - metabolism Neoplasms - pathology Phosphatidylinositol 3-Kinases - metabolism Signal Transduction |
| title | The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation |
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