Mismatch repair protein expression in Amsterdam II criteria-positive patients in Taiwan

Background: Hereditary non‐polyposis colorectal cancer (HNPCC) is characterized genetically by germline mutations in DNA mismatch repair (MMR) genes. Immunohistochemistry (IHC) has high sensitivity and specificity for identifying MMR‐deficient tumours. This study investigated the clinical presentati...

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Veröffentlicht in:	British journal of surgery 2008-01, Vol.95 (1), p.102-110
Hauptverfasser:	Chen, J. R., Chiang, J. M., Changchien, C. R., Chen, J. S., Tang, R. P., Wang, J. Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Adenosine Triphosphatases - deficiency Adenosine Triphosphatases - genetics Adult Aged Biological and medical sciences Cohort Studies Colonic Polyps - epidemiology Colonic Polyps - genetics Colonic Polyps - metabolism Colorectal Neoplasms, Hereditary Nonpolyposis - epidemiology Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism DNA Mismatch Repair DNA Repair Enzymes - deficiency DNA Repair Enzymes - genetics DNA-Binding Proteins - deficiency DNA-Binding Proteins - genetics Female General aspects Humans Immunohistochemistry Male Medical sciences Middle Aged Mismatch Repair Endonuclease PMS2 MutL Protein Homolog 1 MutS Homolog 2 Protein - deficiency MutS Homolog 2 Protein - genetics MutS Homolog 2 Protein - metabolism Neoplasm Proteins - metabolism Neoplasms, Second Primary - epidemiology Neoplasms, Second Primary - genetics Neoplasms, Second Primary - metabolism Nuclear Proteins - deficiency Nuclear Proteins - genetics Nuclear Proteins - metabolism Prevalence Taiwan - epidemiology
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