Nanoparticles of poly(lactide)/vitamin E TPGS copolymer for cancer chemotherapy: Synthesis, formulation, characterization and in vitro drug release

Paclitaxel is one of the best anticancer drugs, which has excellent therapeutic effects against a wide spectrum of cancers. The formulation of paclitaxel used in its currently clinical administration includes Cremophor EL, which has been found to cause serious side effects. Nanoparticle formulation...

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Veröffentlicht in:	Biomaterials 2006, Vol.27 (2), p.262-270
Hauptverfasser:	Zhang, Zhiping, Feng, Si-Shen
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - metabolism Antineoplastic Agents, Phytogenic - therapeutic use Biodegradable polymers Cancer nanotechnology Chemotherapy Drug Carriers - chemistry Drug Therapy - methods Humans Lactic Acid - chemistry Lactic Acid - metabolism Molecular Structure Molecular Weight Nanostructures Neoplasms - drug therapy Paclitaxel Paclitaxel - administration & dosage Paclitaxel - chemistry Paclitaxel - metabolism Paclitaxel - therapeutic use Particle Size Polyesters Polyethylene Glycols - chemistry Polyethylene Glycols - metabolism Polymers - chemistry Polymers - metabolism Surface Properties Taxol Vitamin E - analogs & derivatives Vitamin E - chemistry Vitamin E - metabolism
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