The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak

Aberrant wound-healing responses to injury have been implicated in the development of pulmonary fibrosis, but the mediators directing these pathologic responses have yet to be fully identified. We show that lysophosphatidic acid levels increase in bronchoalveolar lavage fluid following lung injury i...

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Veröffentlicht in:	Nature medicine 2008, Vol.14 (1), p.45-54
Hauptverfasser:	Tager, Andrew M, LaCamera, Peter, Shea, Barry S, Campanella, Gabriele S, Selman, Moisés, Zhao, Zhenwen, Polosukhin, Vasiliy, Wain, John, Karimi-Shah, Banu A, Kim, Nancy D, Hart, William K, Pardo, Annie, Blackwell, Timothy S, Xu, Yan, Chun, Jerold, Luster, Andrew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscess Animals Biomedical and Life Sciences Biomedicine Bleomycin - pharmacology Body fluids Bronchoalveolar Lavage Fluid Cancer Research Cellular signal transduction Chemokine receptors Cystic fibrosis Development and progression Female Fibroblasts - metabolism Infectious Diseases Leukocytes - metabolism Lung - pathology Lung Injury Lungs Lysophospholipids - metabolism Male Medical research Metabolic Diseases Mice Mice, Inbred C57BL Mice, Knockout Models, Biological Molecular Medicine Mortality Neurosciences Pulmonary fibrosis Pulmonary Fibrosis - pathology Receptors, Lysophosphatidic Acid - metabolism Receptors, Lysophosphatidic Acid - physiology Risk factors Wound healing
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