Effects of bovine serum concentrate, with or without supplemental micronutrients, on the growth, morbidity, and micronutrient status of young children in a low-income, peri-urban Guatemalan community
Objective: To determine the effects of dietary supplements containing bovine serum concentrate (BSC, a source of immunoglobulins) and/or multiple micronutrients (MMN) on children's growth velocity, rates of common infections, and MN status. Design: Randomized, controlled, community-based interv...
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| Veröffentlicht in: | European journal of clinical nutrition 2008-01, Vol.62 (1), p.39-50 |
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| description | Objective: To determine the effects of dietary supplements containing bovine serum concentrate (BSC, a source of immunoglobulins) and/or multiple micronutrients (MMN) on children's growth velocity, rates of common infections, and MN status. Design: Randomized, controlled, community-based intervention trial. Setting: Low-income, peri-urban Guatemalan community. Subjects: Children aged 6-7 months initially. Interventions: Children received one of four maize-based dietary supplements daily for 8 months, containing: (1) BSC, (2) whey protein concentrate (WPC, control group), (3) WPC+MMN, or (4) BSC+MMN. Results: There were no significant differences in growth or rates of morbidity by treatment group. Children who received MMN had lower rates of anemia and (in the group that received WPC+MMN) less of a decline in serum ferritin than those who did not, but there were no differences in other biochemical indicators of MN status by treatment group. Conclusions: MMN supplementation reduced anemia and iron deficiency in this population, but the MMN content and source of protein in the supplements did not affect other indicators of MN status, growth or morbidity. |
| doi_str_mv | 10.1038/sj.ejcn.1602682 |
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Design: Randomized, controlled, community-based intervention trial. Setting: Low-income, peri-urban Guatemalan community. Subjects: Children aged 6-7 months initially. Interventions: Children received one of four maize-based dietary supplements daily for 8 months, containing: (1) BSC, (2) whey protein concentrate (WPC, control group), (3) WPC+MMN, or (4) BSC+MMN. Results: There were no significant differences in growth or rates of morbidity by treatment group. Children who received MMN had lower rates of anemia and (in the group that received WPC+MMN) less of a decline in serum ferritin than those who did not, but there were no differences in other biochemical indicators of MN status by treatment group. Conclusions: MMN supplementation reduced anemia and iron deficiency in this population, but the MMN content and source of protein in the supplements did not affect other indicators of MN status, growth or morbidity.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/sj.ejcn.1602682</identifier><identifier>PMID: 17299460</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Anemia - drug therapy ; Anemia - epidemiology ; Anemia - mortality ; Biological and medical sciences ; bovine serum albumin ; Child Development - drug effects ; Children & youth ; Clinical Nutrition ; Complications and side effects ; Corn ; Deficiency Diseases - drug therapy ; Deficiency Diseases - epidemiology ; Deficiency Diseases - mortality ; Diet therapy ; dietary mineral supplements ; Dietary minerals ; Dietary Supplements ; Double-Blind Method ; Epidemiology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Growth - drug effects ; Growth disorders ; Growth Disorders - epidemiology ; Growth Disorders - mortality ; Growth Disorders - prevention & control ; growth retardation ; Guatemala ; Health aspects ; Human growth ; Humans ; Immunoglobulins ; Income ; Infant ; Infant Food ; infant growth ; infant nutrition ; Infant Nutritional Physiological Phenomena ; infants ; Internal Medicine ; low income households ; Male ; Malnutrition in children ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Micronutrients ; Micronutrients - administration & dosage ; Micronutrients - pharmacology ; Milk Proteins ; Morbidity ; Nutrient deficiency ; nutrient reserves ; Nutrition ; nutrition assessment ; Nutritional aspects ; Nutritional Status ; Obesity ; original-article ; Prevalence ; Public Health ; Serum ; Serum Albumin, Bovine - administration & dosage ; Serum Albumin, Bovine - pharmacology ; Socioeconomic Factors ; Treatment Outcome ; urban areas ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; vitamin supplements ; Vitamins ; whey protein ; Whey Proteins</subject><ispartof>European journal of clinical nutrition, 2008-01, Vol.62 (1), p.39-50</ispartof><rights>Springer Nature Limited 2008</rights><rights>2008 INIST-CNRS</rights><rights>COPYRIGHT 2008 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c566t-40fd8728c082accd6b6e1459a0b2b491ab1cd0fe939c8b5a65c11a713edcaf803</citedby><cites>FETCH-LOGICAL-c566t-40fd8728c082accd6b6e1459a0b2b491ab1cd0fe939c8b5a65c11a713edcaf803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ejcn.1602682$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ejcn.1602682$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20043274$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17299460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Begin, F</creatorcontrib><creatorcontrib>Santizo, M.C</creatorcontrib><creatorcontrib>Peerson, J.M</creatorcontrib><creatorcontrib>Torun, B</creatorcontrib><creatorcontrib>Brown, K.H</creatorcontrib><title>Effects of bovine serum concentrate, with or without supplemental micronutrients, on the growth, morbidity, and micronutrient status of young children in a low-income, peri-urban Guatemalan community</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Objective: To determine the effects of dietary supplements containing bovine serum concentrate (BSC, a source of immunoglobulins) and/or multiple micronutrients (MMN) on children's growth velocity, rates of common infections, and MN status. Design: Randomized, controlled, community-based intervention trial. Setting: Low-income, peri-urban Guatemalan community. Subjects: Children aged 6-7 months initially. Interventions: Children received one of four maize-based dietary supplements daily for 8 months, containing: (1) BSC, (2) whey protein concentrate (WPC, control group), (3) WPC+MMN, or (4) BSC+MMN. Results: There were no significant differences in growth or rates of morbidity by treatment group. Children who received MMN had lower rates of anemia and (in the group that received WPC+MMN) less of a decline in serum ferritin than those who did not, but there were no differences in other biochemical indicators of MN status by treatment group. Conclusions: MMN supplementation reduced anemia and iron deficiency in this population, but the MMN content and source of protein in the supplements did not affect other indicators of MN status, growth or morbidity.</description><subject>Anemia - drug therapy</subject><subject>Anemia - epidemiology</subject><subject>Anemia - mortality</subject><subject>Biological and medical sciences</subject><subject>bovine serum albumin</subject><subject>Child Development - drug effects</subject><subject>Children & youth</subject><subject>Clinical Nutrition</subject><subject>Complications and side effects</subject><subject>Corn</subject><subject>Deficiency Diseases - drug therapy</subject><subject>Deficiency Diseases - epidemiology</subject><subject>Deficiency Diseases - mortality</subject><subject>Diet therapy</subject><subject>dietary mineral supplements</subject><subject>Dietary minerals</subject><subject>Dietary Supplements</subject><subject>Double-Blind Method</subject><subject>Epidemiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth - drug effects</subject><subject>Growth disorders</subject><subject>Growth Disorders - epidemiology</subject><subject>Growth Disorders - mortality</subject><subject>Growth Disorders - prevention & control</subject><subject>growth retardation</subject><subject>Guatemala</subject><subject>Health aspects</subject><subject>Human growth</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Income</subject><subject>Infant</subject><subject>Infant Food</subject><subject>infant growth</subject><subject>infant nutrition</subject><subject>Infant Nutritional Physiological Phenomena</subject><subject>infants</subject><subject>Internal Medicine</subject><subject>low income households</subject><subject>Male</subject><subject>Malnutrition in children</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Micronutrients</subject><subject>Micronutrients - administration & dosage</subject><subject>Micronutrients - pharmacology</subject><subject>Milk Proteins</subject><subject>Morbidity</subject><subject>Nutrient deficiency</subject><subject>nutrient reserves</subject><subject>Nutrition</subject><subject>nutrition assessment</subject><subject>Nutritional aspects</subject><subject>Nutritional Status</subject><subject>Obesity</subject><subject>original-article</subject><subject>Prevalence</subject><subject>Public Health</subject><subject>Serum</subject><subject>Serum Albumin, Bovine - administration & dosage</subject><subject>Serum Albumin, Bovine - pharmacology</subject><subject>Socioeconomic Factors</subject><subject>Treatment Outcome</subject><subject>urban areas</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>vitamin supplements</subject><subject>Vitamins</subject><subject>whey protein</subject><subject>Whey Proteins</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kk1v1DAQhiMEokvhzA0sJHrabG0ncZJjVZWCVIkD9Bw5zjjrVWIv_mC1v5C_xbS7ohQV-TC255kPj98se8voitGiOQ-bFWyUXTFBuWj4s2zBylrklSjp82xB26rMC0rrk-xVCBtK0Vnzl9kJq3nbloIusl9XWoOKgThNevfTWCABfJqJclaBjV5GWJKdiWvi_L11KZKQttsJZvTLicxGeWdT9AbPYUmcJXENZPRuF9dLMjvfm8HE_ZJIOzymSYgypvvie5fsSNTaTIMHS4wlkkxulxur3IwtbMGbPPleWnKdsKlZTrhF35wsJn-dvdByCvDmaE-z209X3y8_5zdfr79cXtzkqhIi5iXVQ1PzRtGGS6UG0QtgZdVK2vO-bJnsmRqohrZoVdNXUlSKMVmzAgYldUOL0-zskHfr3Y8EIXazCQombAZcCl1NWVPUdYHgh3_AjUveYm8dZ62oKeUcofwAjXKCzljtcOBqBAteTs6CNnh9wdqyLRnmRH71BI9rAJzrkwFnfwWsQU5xHdyUonE2PAbPDyD-TggedLf1ZpZ-3zHa3UmtC5vuTmrdUWoY8e74wNTPMDzwR20h8PEIyKDkpL20yoQ_HKe0LHhdIkcPXECXHcE_TOr_td8fQrR0nRw9pr39xilDrTei5VVb_Abo1Pqo</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Begin, F</creator><creator>Santizo, M.C</creator><creator>Peerson, J.M</creator><creator>Torun, B</creator><creator>Brown, K.H</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Effects of bovine serum concentrate, with or without supplemental micronutrients, on the growth, morbidity, and micronutrient status of young children in a low-income, peri-urban Guatemalan community</title><author>Begin, F ; Santizo, M.C ; Peerson, J.M ; Torun, B ; Brown, K.H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c566t-40fd8728c082accd6b6e1459a0b2b491ab1cd0fe939c8b5a65c11a713edcaf803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anemia - drug therapy</topic><topic>Anemia - epidemiology</topic><topic>Anemia - mortality</topic><topic>Biological and medical sciences</topic><topic>bovine serum albumin</topic><topic>Child Development - drug effects</topic><topic>Children & youth</topic><topic>Clinical Nutrition</topic><topic>Complications and side effects</topic><topic>Corn</topic><topic>Deficiency Diseases - drug therapy</topic><topic>Deficiency Diseases - epidemiology</topic><topic>Deficiency Diseases - mortality</topic><topic>Diet therapy</topic><topic>dietary mineral supplements</topic><topic>Dietary minerals</topic><topic>Dietary Supplements</topic><topic>Double-Blind Method</topic><topic>Epidemiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth - drug effects</topic><topic>Growth disorders</topic><topic>Growth Disorders - epidemiology</topic><topic>Growth Disorders - mortality</topic><topic>Growth Disorders - prevention & control</topic><topic>growth retardation</topic><topic>Guatemala</topic><topic>Health aspects</topic><topic>Human growth</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Income</topic><topic>Infant</topic><topic>Infant Food</topic><topic>infant growth</topic><topic>infant nutrition</topic><topic>Infant Nutritional Physiological Phenomena</topic><topic>infants</topic><topic>Internal Medicine</topic><topic>low income households</topic><topic>Male</topic><topic>Malnutrition in children</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Micronutrients</topic><topic>Micronutrients - administration & dosage</topic><topic>Micronutrients - pharmacology</topic><topic>Milk Proteins</topic><topic>Morbidity</topic><topic>Nutrient deficiency</topic><topic>nutrient reserves</topic><topic>Nutrition</topic><topic>nutrition assessment</topic><topic>Nutritional aspects</topic><topic>Nutritional Status</topic><topic>Obesity</topic><topic>original-article</topic><topic>Prevalence</topic><topic>Public Health</topic><topic>Serum</topic><topic>Serum Albumin, Bovine - administration & dosage</topic><topic>Serum Albumin, Bovine - pharmacology</topic><topic>Socioeconomic Factors</topic><topic>Treatment Outcome</topic><topic>urban areas</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>vitamin supplements</topic><topic>Vitamins</topic><topic>whey protein</topic><topic>Whey Proteins</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Begin, F</creatorcontrib><creatorcontrib>Santizo, M.C</creatorcontrib><creatorcontrib>Peerson, J.M</creatorcontrib><creatorcontrib>Torun, B</creatorcontrib><creatorcontrib>Brown, K.H</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Begin, F</au><au>Santizo, M.C</au><au>Peerson, J.M</au><au>Torun, B</au><au>Brown, K.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of bovine serum concentrate, with or without supplemental micronutrients, on the growth, morbidity, and micronutrient status of young children in a low-income, peri-urban Guatemalan community</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>62</volume><issue>1</issue><spage>39</spage><epage>50</epage><pages>39-50</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Objective: To determine the effects of dietary supplements containing bovine serum concentrate (BSC, a source of immunoglobulins) and/or multiple micronutrients (MMN) on children's growth velocity, rates of common infections, and MN status. Design: Randomized, controlled, community-based intervention trial. Setting: Low-income, peri-urban Guatemalan community. Subjects: Children aged 6-7 months initially. Interventions: Children received one of four maize-based dietary supplements daily for 8 months, containing: (1) BSC, (2) whey protein concentrate (WPC, control group), (3) WPC+MMN, or (4) BSC+MMN. Results: There were no significant differences in growth or rates of morbidity by treatment group. Children who received MMN had lower rates of anemia and (in the group that received WPC+MMN) less of a decline in serum ferritin than those who did not, but there were no differences in other biochemical indicators of MN status by treatment group. Conclusions: MMN supplementation reduced anemia and iron deficiency in this population, but the MMN content and source of protein in the supplements did not affect other indicators of MN status, growth or morbidity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>17299460</pmid><doi>10.1038/sj.ejcn.1602682</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anemia - drug therapy Anemia - epidemiology Anemia - mortality Biological and medical sciences bovine serum albumin Child Development - drug effects Children & youth Clinical Nutrition Complications and side effects Corn Deficiency Diseases - drug therapy Deficiency Diseases - epidemiology Deficiency Diseases - mortality Diet therapy dietary mineral supplements Dietary minerals Dietary Supplements Double-Blind Method Epidemiology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Growth - drug effects Growth disorders Growth Disorders - epidemiology Growth Disorders - mortality Growth Disorders - prevention & control growth retardation Guatemala Health aspects Human growth Humans Immunoglobulins Income Infant Infant Food infant growth infant nutrition Infant Nutritional Physiological Phenomena infants Internal Medicine low income households Male Malnutrition in children Medical sciences Medicine Medicine & Public Health Metabolic Diseases Micronutrients Micronutrients - administration & dosage Micronutrients - pharmacology Milk Proteins Morbidity Nutrient deficiency nutrient reserves Nutrition nutrition assessment Nutritional aspects Nutritional Status Obesity original-article Prevalence Public Health Serum Serum Albumin, Bovine - administration & dosage Serum Albumin, Bovine - pharmacology Socioeconomic Factors Treatment Outcome urban areas Vertebrates: anatomy and physiology, studies on body, several organs or systems vitamin supplements Vitamins whey protein Whey Proteins |
| title | Effects of bovine serum concentrate, with or without supplemental micronutrients, on the growth, morbidity, and micronutrient status of young children in a low-income, peri-urban Guatemalan community |
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