Curcumin treatment enhances islet recovery by induction of heat shock response proteins, Hsp70 and heme oxygenase-1, during cryopreservation

Limited recovery of islets post-cryopreservation influences graft survival and transplantation efficiency during diabetes treatment. As curcumin, a potent antioxidant/radical scavenging compound, protects islets against beta cell toxins, we hypothesized that inclusion of curcumin during cryopreserva...

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Veröffentlicht in:	Life sciences (1973) 2008-01, Vol.82 (3), p.182-189
Hauptverfasser:	Kanitkar, Meghana, Bhonde, Ramesh R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Culture Techniques Cell Survival - drug effects Cryopreservation Cryopreservation - methods Cryoprotective Agents - pharmacology Curcumin Curcumin - pharmacology Dose-Response Relationship, Drug Female Heme Oxygenase-1 - metabolism HO-1 Hsp70 HSP70 Heat-Shock Proteins - metabolism Insulin - metabolism Islets of Langerhans Islets of Langerhans - cytology Islets of Langerhans - drug effects Islets of Langerhans - metabolism Islets of Langerhans Transplantation Male Mice Reactive Oxygen Species - metabolism Tissue Preservation
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