Genetic influence in antithrombotic actions of atorvastatin in hypercholesterolaemia

ABSTRACT Background Recent data indicate that statins could offer coronary artery disease (CAD) benefit even by mechanisms beyond lipid lowering. Genetic influence has been shown for some antithrombotic actions of statins via oxidized‐low‐density lipoprotein cholesterol (ox‐LDL) receptors and nitri...

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Veröffentlicht in:	European journal of clinical investigation 2008-01, Vol.38 (1), p.11-16
Hauptverfasser:	Puccetti, L., Bruni, F., Pasqui, A. L., Pastorelli, M., Ciani, F., Palazzuoli, A., Acampa, M., Auteri, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute cardiovascular events Adolescent Adult Aged Anticholesteremic Agents - blood Anticholesteremic Agents - therapeutic use atorvastatin Atorvastatin Calcium Biological and medical sciences Coronary Artery Disease - genetics Disorders of blood lipids. Hyperlipoproteinemia Female Fibrinolytic Agents - therapeutic use General aspects Heptanoic Acids - blood Heptanoic Acids - therapeutic use Humans hypercholesterolaemia Hypercholesterolemia - blood Hypercholesterolemia - drug therapy Hypercholesterolemia - genetics Lipoproteins, LDL - blood Lipoproteins, LDL - metabolism LOX-1 Male Medical sciences Metabolic diseases Middle Aged Nitric Oxide Synthase - genetics NOS Polymorphism, Genetic Pyrroles - blood Pyrroles - therapeutic use Scavenger Receptors, Class E - genetics
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