Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease
ABSTRACT The biological importance of the aquaporin family of water channels was recently acknowledged by the 2003 Nobel Prize for Chemistry awarded to the discovering scientist Peter Agre. Among the pleiotropic roles exerted by aquaporins in nature in both health and disease, the review addresses t...
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| Veröffentlicht in: | European journal of clinical investigation 2008-01, Vol.38 (1), p.1-10 |
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| creator | Portincasa, P. Palasciano, G. Svelto, M. Calamita, G. |
| description | ABSTRACT
The biological importance of the aquaporin family of water channels was recently acknowledged by the 2003 Nobel Prize for Chemistry awarded to the discovering scientist Peter Agre. Among the pleiotropic roles exerted by aquaporins in nature in both health and disease, the review addresses the latest acquisitions about the expression and regulation, as well as physiology and pathophysiology of aquaporins in the hepatobiliary tract.
Of note, at least seven out of the thirteen mammalian aquaporins are expressed in the liver, bile ducts and gallbladder. Aquaporins are essential for bile water secretion and reabsorption, as well as for plasma glycerol uptake by the hepatocyte and its conversion to glucose during starvation. Novel data are emerging regarding the physio‐pathological involvement of aquaporins in multiple diseases such as cholestases, liver cirrhosis, obesity and insulin resistance, fatty liver, gallstone formation and even microparasite invasion of intrahepatic bile ducts. This body of knowledge represents the mainstay of present and future research in a rapidly expanding field. |
| doi_str_mv | 10.1111/j.1365-2362.2007.01897.x |
| format | Article |
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The biological importance of the aquaporin family of water channels was recently acknowledged by the 2003 Nobel Prize for Chemistry awarded to the discovering scientist Peter Agre. Among the pleiotropic roles exerted by aquaporins in nature in both health and disease, the review addresses the latest acquisitions about the expression and regulation, as well as physiology and pathophysiology of aquaporins in the hepatobiliary tract.
Of note, at least seven out of the thirteen mammalian aquaporins are expressed in the liver, bile ducts and gallbladder. Aquaporins are essential for bile water secretion and reabsorption, as well as for plasma glycerol uptake by the hepatocyte and its conversion to glucose during starvation. Novel data are emerging regarding the physio‐pathological involvement of aquaporins in multiple diseases such as cholestases, liver cirrhosis, obesity and insulin resistance, fatty liver, gallstone formation and even microparasite invasion of intrahepatic bile ducts. This body of knowledge represents the mainstay of present and future research in a rapidly expanding field.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1111/j.1365-2362.2007.01897.x</identifier><identifier>PMID: 18173545</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aquaporins - physiology ; Biliary Tract - physiology ; Biliary Tract Diseases - physiopathology ; Biological and medical sciences ; Biological Transport ; Cholestasis ; gallstones ; General aspects ; glycerol ; Hepatocytes - metabolism ; Humans ; Kidney Diseases - physiopathology ; Liver Diseases - physiopathology ; Medical sciences ; membrane transport ; Miscellaneous ; obesity ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; water channels</subject><ispartof>European journal of clinical investigation, 2008-01, Vol.38 (1), p.1-10</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4357-3f5e409dacba01090f6b3cacb7a28ebbbbb72ae88d828c5b79e3a8df2445c8e3</citedby><cites>FETCH-LOGICAL-c4357-3f5e409dacba01090f6b3cacb7a28ebbbbb72ae88d828c5b79e3a8df2445c8e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2362.2007.01897.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2362.2007.01897.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19998706$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18173545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Portincasa, P.</creatorcontrib><creatorcontrib>Palasciano, G.</creatorcontrib><creatorcontrib>Svelto, M.</creatorcontrib><creatorcontrib>Calamita, G.</creatorcontrib><title>Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease</title><title>European journal of clinical investigation</title><addtitle>Eur J Clin Invest</addtitle><description>ABSTRACT
The biological importance of the aquaporin family of water channels was recently acknowledged by the 2003 Nobel Prize for Chemistry awarded to the discovering scientist Peter Agre. Among the pleiotropic roles exerted by aquaporins in nature in both health and disease, the review addresses the latest acquisitions about the expression and regulation, as well as physiology and pathophysiology of aquaporins in the hepatobiliary tract.
Of note, at least seven out of the thirteen mammalian aquaporins are expressed in the liver, bile ducts and gallbladder. Aquaporins are essential for bile water secretion and reabsorption, as well as for plasma glycerol uptake by the hepatocyte and its conversion to glucose during starvation. Novel data are emerging regarding the physio‐pathological involvement of aquaporins in multiple diseases such as cholestases, liver cirrhosis, obesity and insulin resistance, fatty liver, gallstone formation and even microparasite invasion of intrahepatic bile ducts. This body of knowledge represents the mainstay of present and future research in a rapidly expanding field.</description><subject>Aquaporins - physiology</subject><subject>Biliary Tract - physiology</subject><subject>Biliary Tract Diseases - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Biological Transport</subject><subject>Cholestasis</subject><subject>gallstones</subject><subject>General aspects</subject><subject>glycerol</subject><subject>Hepatocytes - metabolism</subject><subject>Humans</subject><subject>Kidney Diseases - physiopathology</subject><subject>Liver Diseases - physiopathology</subject><subject>Medical sciences</subject><subject>membrane transport</subject><subject>Miscellaneous</subject><subject>obesity</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>water channels</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EokvhLyBf4NQEf8Sxc-BQrdpSUYpUVarExZo4E8VLNtnaWXX33-N0V-2VuXiseV5_PIRQznKe6tsq57JUmZClyAVjOmfcVDrfvSGLl8FbsmCMF5motDghH2JcMcYMl-I9OeGGa6kKtSB_zh-3sBmDHyL1A506pB1uYBpr33sIezoFcFNOHzrvujP61GFACkOTOphmfE-bcU52CP3UPY8aHxEifiTvWugjfjqup-T-8uJ--SO7-X11vTy_yVwhlc5kq7BgVQOuBsZZxdqyli7tNAiD9VxaABrTGGGcqnWFEkzTiqJQzqA8JV8Px27C-LjFONm1jw77HgYct9Hq5EaYSiXQHEAXxhgDtnYT_Dr90XJmZ612ZWd7drZnZ632Wavdpejn4x3beo3Na_DoMQFfjgBEB30bYHA-vnJVVRnNysR9P3BPvsf9fz_AXiyv5y7ls0Pexwl3L3kIf22ppVb24fbKXnIp7379vLO38h_UvKLv</recordid><startdate>200801</startdate><enddate>200801</enddate><creator>Portincasa, P.</creator><creator>Palasciano, G.</creator><creator>Svelto, M.</creator><creator>Calamita, G.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200801</creationdate><title>Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease</title><author>Portincasa, P. ; Palasciano, G. ; Svelto, M. ; Calamita, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4357-3f5e409dacba01090f6b3cacb7a28ebbbbb72ae88d828c5b79e3a8df2445c8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aquaporins - physiology</topic><topic>Biliary Tract - physiology</topic><topic>Biliary Tract Diseases - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Biological Transport</topic><topic>Cholestasis</topic><topic>gallstones</topic><topic>General aspects</topic><topic>glycerol</topic><topic>Hepatocytes - metabolism</topic><topic>Humans</topic><topic>Kidney Diseases - physiopathology</topic><topic>Liver Diseases - physiopathology</topic><topic>Medical sciences</topic><topic>membrane transport</topic><topic>Miscellaneous</topic><topic>obesity</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>water channels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Portincasa, P.</creatorcontrib><creatorcontrib>Palasciano, G.</creatorcontrib><creatorcontrib>Svelto, M.</creatorcontrib><creatorcontrib>Calamita, G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Portincasa, P.</au><au>Palasciano, G.</au><au>Svelto, M.</au><au>Calamita, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aquaporins in the hepatobiliary tract. 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The biological importance of the aquaporin family of water channels was recently acknowledged by the 2003 Nobel Prize for Chemistry awarded to the discovering scientist Peter Agre. Among the pleiotropic roles exerted by aquaporins in nature in both health and disease, the review addresses the latest acquisitions about the expression and regulation, as well as physiology and pathophysiology of aquaporins in the hepatobiliary tract.
Of note, at least seven out of the thirteen mammalian aquaporins are expressed in the liver, bile ducts and gallbladder. Aquaporins are essential for bile water secretion and reabsorption, as well as for plasma glycerol uptake by the hepatocyte and its conversion to glucose during starvation. Novel data are emerging regarding the physio‐pathological involvement of aquaporins in multiple diseases such as cholestases, liver cirrhosis, obesity and insulin resistance, fatty liver, gallstone formation and even microparasite invasion of intrahepatic bile ducts. This body of knowledge represents the mainstay of present and future research in a rapidly expanding field.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18173545</pmid><doi>10.1111/j.1365-2362.2007.01897.x</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aquaporins - physiology Biliary Tract - physiology Biliary Tract Diseases - physiopathology Biological and medical sciences Biological Transport Cholestasis gallstones General aspects glycerol Hepatocytes - metabolism Humans Kidney Diseases - physiopathology Liver Diseases - physiopathology Medical sciences membrane transport Miscellaneous obesity Public health. Hygiene Public health. Hygiene-occupational medicine water channels |
| title | Aquaporins in the hepatobiliary tract. Which, where and what they do in health and disease |
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