Improvement of Ca balance by Fructus Ligustri Lucidi extract in aged female rats
Summary This study aimed to demonstrate and delineate the mechanism of action of Fructus Ligustri Lucidi (FLL) involved in improving Ca balance in aged female rats. FLL could enhance the apparent Ca absorption rate and reduce Ca excretion, via its actions on modulating the levels of calciotropic hor...
Gespeichert in:
| Veröffentlicht in: | Osteoporosis international 2008-02, Vol.19 (2), p.235-242 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 242 |
|---|---|
| container_issue | 2 |
| container_start_page | 235 |
| container_title | Osteoporosis international |
| container_volume | 19 |
| creator | Zhang, Y. Lai, W.-P. Leung, P.-C. Che, C.-T. Wong, M.-S. |
| description | Summary
This study aimed to demonstrate and delineate the mechanism of action of
Fructus Ligustri Lucidi
(FLL) involved in improving Ca balance in aged female rats. FLL could enhance the apparent Ca absorption rate and reduce Ca excretion, via its actions on modulating the levels of calciotropic hormones and CaBPs expression.
Introduction
Fructus Ligustri Lucidi
(FLL) is a herb classically used for the treatment of age-related symptoms in China. The present study aimed to determine if FLL could improve calcium balance in aged female rats and delineate its mechanism of action in vivo.
Methods
Aged Sprague-Dawley rats (11 months of age) were orally administered with ethanol extract of FLL or its vehicle and fed with diets containing different levels of Ca (low Ca diet, LCD, 0.1% Ca; medium Ca diet, MCD, 0.6% Ca; high Ca diet, HCD, 1.2% Ca) for 12 weeks. Serum, urine and feces were collected for biochemical markers and Ca balance determination. mRNA expressions of calcium binding proteins (CaBPs) were determined by real time RT-PCR. The effects of diets and herb were analyzed by both one-way and two-way ANOVA.
Results
FLL significantly reduced fecal Ca excretion and induced apparent Ca absorption rate in rats fed with MCD and HCD. FLL increased serum 1,25(OH)
2
D
3
level and duodenal CaBP-9k mRNA expressions in all rats. Renal CaBP-28k mRNA expressions were induced in rats fed with MCD and HCD upon FLL treatment.
Conclusions
Our study demonstrated that FLL improved Ca balance in aged female rats by increasing serum 1,25 (OH)
2
D
3
level and vitamin D-dependent CaBPs expression. |
| doi_str_mv | 10.1007/s00198-007-0442-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70181152</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70181152</sourcerecordid><originalsourceid>FETCH-LOGICAL-c399t-35034ba320ed78050062fdc86cf4f05be27113f495b3490ce00bfc2bb79b657b3</originalsourceid><addsrcrecordid>eNp1kE2LFDEQhoO4uOPqD_AiQVhvrZWvTnKUYVcXBtyDgreQpCtDL_2xJt2y--_NMAMDgqcqqKeqXh5C3jH4xAD05wLArGlq24CUvLEvyIZJIRpuW_WSbMAK3VjJfl2S16U8QAWt1a_IJdO6NcqYDbm_Gx_z_AdHnBY6J7r1NPjBTxFpeKa3eY3LWuiu369lyT3drbHveopPS_Zxof1E_R47mnD0A9Lsl_KGXCQ_FHx7qlfk5-3Nj-23Zvf96932y66JwtqlEQqEDF5wwE4bUAAtT100bUwygQrINWMiSauCkBYiAoQUeQjahlbpIK7Ix-PdGv_3imVxY18iDjU7zmtxGphhTPEKfvgHfJjXPNVsjjNjGOdcVYgdoZjnUjIm95j70ednx8AdXLuja3doD66drTvvT4fXMGJ33jjJrcD1CfAl-iHlqrUvZ85aY0DLyvEjV-po2mM-J_z_97_c35UX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218812225</pqid></control><display><type>article</type><title>Improvement of Ca balance by Fructus Ligustri Lucidi extract in aged female rats</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Zhang, Y. ; Lai, W.-P. ; Leung, P.-C. ; Che, C.-T. ; Wong, M.-S.</creator><creatorcontrib>Zhang, Y. ; Lai, W.-P. ; Leung, P.-C. ; Che, C.-T. ; Wong, M.-S.</creatorcontrib><description>Summary
This study aimed to demonstrate and delineate the mechanism of action of
Fructus Ligustri Lucidi
(FLL) involved in improving Ca balance in aged female rats. FLL could enhance the apparent Ca absorption rate and reduce Ca excretion, via its actions on modulating the levels of calciotropic hormones and CaBPs expression.
Introduction
Fructus Ligustri Lucidi
(FLL) is a herb classically used for the treatment of age-related symptoms in China. The present study aimed to determine if FLL could improve calcium balance in aged female rats and delineate its mechanism of action in vivo.
Methods
Aged Sprague-Dawley rats (11 months of age) were orally administered with ethanol extract of FLL or its vehicle and fed with diets containing different levels of Ca (low Ca diet, LCD, 0.1% Ca; medium Ca diet, MCD, 0.6% Ca; high Ca diet, HCD, 1.2% Ca) for 12 weeks. Serum, urine and feces were collected for biochemical markers and Ca balance determination. mRNA expressions of calcium binding proteins (CaBPs) were determined by real time RT-PCR. The effects of diets and herb were analyzed by both one-way and two-way ANOVA.
Results
FLL significantly reduced fecal Ca excretion and induced apparent Ca absorption rate in rats fed with MCD and HCD. FLL increased serum 1,25(OH)
2
D
3
level and duodenal CaBP-9k mRNA expressions in all rats. Renal CaBP-28k mRNA expressions were induced in rats fed with MCD and HCD upon FLL treatment.
Conclusions
Our study demonstrated that FLL improved Ca balance in aged female rats by increasing serum 1,25 (OH)
2
D
3
level and vitamin D-dependent CaBPs expression.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-007-0442-9</identifier><identifier>PMID: 17768588</identifier><language>eng</language><publisher>London: Springer-Verlag</publisher><subject>Animals ; Biological and medical sciences ; Body Weight ; Calbindins ; Calcitriol - blood ; Calcium ; Calcium - metabolism ; Calcium, Dietary - administration & dosage ; Diseases of the osteoarticular system ; Duodenum - metabolism ; Effects ; Endocrinology ; Female ; Females ; Gene Expression ; Herbal medicine ; Intestinal Absorption - drug effects ; Kidney - metabolism ; Ligustrum ; Medical sciences ; Medicine ; Medicine & Public Health ; Original Article ; Orthopedics ; Osteoporosis. Osteomalacia. Paget disease ; Parathyroid Hormone - blood ; Phytotherapy ; Plant Extracts - pharmacology ; Rats ; Rats, Sprague-Dawley ; Rheumatology ; Rodents ; S100 Calcium Binding Protein G - metabolism</subject><ispartof>Osteoporosis international, 2008-02, Vol.19 (2), p.235-242</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2007</rights><rights>2008 INIST-CNRS</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-35034ba320ed78050062fdc86cf4f05be27113f495b3490ce00bfc2bb79b657b3</citedby><cites>FETCH-LOGICAL-c399t-35034ba320ed78050062fdc86cf4f05be27113f495b3490ce00bfc2bb79b657b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-007-0442-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-007-0442-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,41471,42540,51302</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19988074$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17768588$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Y.</creatorcontrib><creatorcontrib>Lai, W.-P.</creatorcontrib><creatorcontrib>Leung, P.-C.</creatorcontrib><creatorcontrib>Che, C.-T.</creatorcontrib><creatorcontrib>Wong, M.-S.</creatorcontrib><title>Improvement of Ca balance by Fructus Ligustri Lucidi extract in aged female rats</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary
This study aimed to demonstrate and delineate the mechanism of action of
Fructus Ligustri Lucidi
(FLL) involved in improving Ca balance in aged female rats. FLL could enhance the apparent Ca absorption rate and reduce Ca excretion, via its actions on modulating the levels of calciotropic hormones and CaBPs expression.
Introduction
Fructus Ligustri Lucidi
(FLL) is a herb classically used for the treatment of age-related symptoms in China. The present study aimed to determine if FLL could improve calcium balance in aged female rats and delineate its mechanism of action in vivo.
Methods
Aged Sprague-Dawley rats (11 months of age) were orally administered with ethanol extract of FLL or its vehicle and fed with diets containing different levels of Ca (low Ca diet, LCD, 0.1% Ca; medium Ca diet, MCD, 0.6% Ca; high Ca diet, HCD, 1.2% Ca) for 12 weeks. Serum, urine and feces were collected for biochemical markers and Ca balance determination. mRNA expressions of calcium binding proteins (CaBPs) were determined by real time RT-PCR. The effects of diets and herb were analyzed by both one-way and two-way ANOVA.
Results
FLL significantly reduced fecal Ca excretion and induced apparent Ca absorption rate in rats fed with MCD and HCD. FLL increased serum 1,25(OH)
2
D
3
level and duodenal CaBP-9k mRNA expressions in all rats. Renal CaBP-28k mRNA expressions were induced in rats fed with MCD and HCD upon FLL treatment.
Conclusions
Our study demonstrated that FLL improved Ca balance in aged female rats by increasing serum 1,25 (OH)
2
D
3
level and vitamin D-dependent CaBPs expression.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Calbindins</subject><subject>Calcitriol - blood</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>Calcium, Dietary - administration & dosage</subject><subject>Diseases of the osteoarticular system</subject><subject>Duodenum - metabolism</subject><subject>Effects</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Females</subject><subject>Gene Expression</subject><subject>Herbal medicine</subject><subject>Intestinal Absorption - drug effects</subject><subject>Kidney - metabolism</subject><subject>Ligustrum</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Parathyroid Hormone - blood</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Rheumatology</subject><subject>Rodents</subject><subject>S100 Calcium Binding Protein G - metabolism</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE2LFDEQhoO4uOPqD_AiQVhvrZWvTnKUYVcXBtyDgreQpCtDL_2xJt2y--_NMAMDgqcqqKeqXh5C3jH4xAD05wLArGlq24CUvLEvyIZJIRpuW_WSbMAK3VjJfl2S16U8QAWt1a_IJdO6NcqYDbm_Gx_z_AdHnBY6J7r1NPjBTxFpeKa3eY3LWuiu369lyT3drbHveopPS_Zxof1E_R47mnD0A9Lsl_KGXCQ_FHx7qlfk5-3Nj-23Zvf96932y66JwtqlEQqEDF5wwE4bUAAtT100bUwygQrINWMiSauCkBYiAoQUeQjahlbpIK7Ix-PdGv_3imVxY18iDjU7zmtxGphhTPEKfvgHfJjXPNVsjjNjGOdcVYgdoZjnUjIm95j70ednx8AdXLuja3doD66drTvvT4fXMGJ33jjJrcD1CfAl-iHlqrUvZ85aY0DLyvEjV-po2mM-J_z_97_c35UX</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Zhang, Y.</creator><creator>Lai, W.-P.</creator><creator>Leung, P.-C.</creator><creator>Che, C.-T.</creator><creator>Wong, M.-S.</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20080201</creationdate><title>Improvement of Ca balance by Fructus Ligustri Lucidi extract in aged female rats</title><author>Zhang, Y. ; Lai, W.-P. ; Leung, P.-C. ; Che, C.-T. ; Wong, M.-S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-35034ba320ed78050062fdc86cf4f05be27113f495b3490ce00bfc2bb79b657b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Calbindins</topic><topic>Calcitriol - blood</topic><topic>Calcium</topic><topic>Calcium - metabolism</topic><topic>Calcium, Dietary - administration & dosage</topic><topic>Diseases of the osteoarticular system</topic><topic>Duodenum - metabolism</topic><topic>Effects</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Females</topic><topic>Gene Expression</topic><topic>Herbal medicine</topic><topic>Intestinal Absorption - drug effects</topic><topic>Kidney - metabolism</topic><topic>Ligustrum</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Parathyroid Hormone - blood</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Rheumatology</topic><topic>Rodents</topic><topic>S100 Calcium Binding Protein G - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Y.</creatorcontrib><creatorcontrib>Lai, W.-P.</creatorcontrib><creatorcontrib>Leung, P.-C.</creatorcontrib><creatorcontrib>Che, C.-T.</creatorcontrib><creatorcontrib>Wong, M.-S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Y.</au><au>Lai, W.-P.</au><au>Leung, P.-C.</au><au>Che, C.-T.</au><au>Wong, M.-S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improvement of Ca balance by Fructus Ligustri Lucidi extract in aged female rats</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>19</volume><issue>2</issue><spage>235</spage><epage>242</epage><pages>235-242</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary
This study aimed to demonstrate and delineate the mechanism of action of
Fructus Ligustri Lucidi
(FLL) involved in improving Ca balance in aged female rats. FLL could enhance the apparent Ca absorption rate and reduce Ca excretion, via its actions on modulating the levels of calciotropic hormones and CaBPs expression.
Introduction
Fructus Ligustri Lucidi
(FLL) is a herb classically used for the treatment of age-related symptoms in China. The present study aimed to determine if FLL could improve calcium balance in aged female rats and delineate its mechanism of action in vivo.
Methods
Aged Sprague-Dawley rats (11 months of age) were orally administered with ethanol extract of FLL or its vehicle and fed with diets containing different levels of Ca (low Ca diet, LCD, 0.1% Ca; medium Ca diet, MCD, 0.6% Ca; high Ca diet, HCD, 1.2% Ca) for 12 weeks. Serum, urine and feces were collected for biochemical markers and Ca balance determination. mRNA expressions of calcium binding proteins (CaBPs) were determined by real time RT-PCR. The effects of diets and herb were analyzed by both one-way and two-way ANOVA.
Results
FLL significantly reduced fecal Ca excretion and induced apparent Ca absorption rate in rats fed with MCD and HCD. FLL increased serum 1,25(OH)
2
D
3
level and duodenal CaBP-9k mRNA expressions in all rats. Renal CaBP-28k mRNA expressions were induced in rats fed with MCD and HCD upon FLL treatment.
Conclusions
Our study demonstrated that FLL improved Ca balance in aged female rats by increasing serum 1,25 (OH)
2
D
3
level and vitamin D-dependent CaBPs expression.</abstract><cop>London</cop><pub>Springer-Verlag</pub><pmid>17768588</pmid><doi>10.1007/s00198-007-0442-9</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0937-941X |
| ispartof | Osteoporosis international, 2008-02, Vol.19 (2), p.235-242 |
| issn | 0937-941X 1433-2965 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70181152 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Biological and medical sciences Body Weight Calbindins Calcitriol - blood Calcium Calcium - metabolism Calcium, Dietary - administration & dosage Diseases of the osteoarticular system Duodenum - metabolism Effects Endocrinology Female Females Gene Expression Herbal medicine Intestinal Absorption - drug effects Kidney - metabolism Ligustrum Medical sciences Medicine Medicine & Public Health Original Article Orthopedics Osteoporosis. Osteomalacia. Paget disease Parathyroid Hormone - blood Phytotherapy Plant Extracts - pharmacology Rats Rats, Sprague-Dawley Rheumatology Rodents S100 Calcium Binding Protein G - metabolism |
| title | Improvement of Ca balance by Fructus Ligustri Lucidi extract in aged female rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T01%3A54%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Improvement%20of%20Ca%20balance%20by%20Fructus%20Ligustri%20Lucidi%20extract%20in%20aged%20female%20rats&rft.jtitle=Osteoporosis%20international&rft.au=Zhang,%20Y.&rft.date=2008-02-01&rft.volume=19&rft.issue=2&rft.spage=235&rft.epage=242&rft.pages=235-242&rft.issn=0937-941X&rft.eissn=1433-2965&rft_id=info:doi/10.1007/s00198-007-0442-9&rft_dat=%3Cproquest_cross%3E70181152%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=218812225&rft_id=info:pmid/17768588&rfr_iscdi=true |