Antiplatelet and antithrombotic activity of indole-3-carbinol in vitro and in vivo

Indole-3-carbinol, a natural compound found in cruciferous vegetables, is known to have anticancer activity. In the present study, the antiplatelet and antithrombotic activities of indole-3-carbinol were investigated in vitro and in vivo. Indole-3-carbinol significantly inhibited collagen-induced pl...

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Veröffentlicht in:	Phytotherapy research 2008-01, Vol.22 (1), p.58-64
Hauptverfasser:	Park, Min-Kyu, Rhee, Yun-Hee, Lee, Hyo-Jung, Lee, Eun-Ok, Kim, Kwan-Hyun, Park, Min-Jong, Jeon, Byung-Hun, Shim, Bum-Sang, Jung, Chang-Hyun, Choi, Seung-Hoon, Ahn, Kyoo-Seok, Kim, Sung-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antiplatelet activity antithrombotic agent Biological and medical sciences Collagen - pharmacology Dinoprostone - metabolism Dose-Response Relationship, Drug Epinephrine - metabolism Fibrinogen - metabolism Fibrinolytic Agents - chemistry Fibrinolytic Agents - pharmacology Flow Cytometry General pharmacology glycoprotein IIb/IIIa Humans indole-3-carbinol Indoles - chemistry Indoles - pharmacology Medical sciences Mice Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - chemistry Platelet Aggregation Inhibitors - pharmacology Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Protein Binding - drug effects thromboxane B2 Thromboxane B2 - metabolism
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