Maternal obesity and familial history of diabetes have opposing effects on infant birth weight in women with mild glucose intolerance in pregnancy
Objective. Pregnant women with an abnormal screening glucose challenge test (GCT) but without gestational diabetes mellitus (GDM) on subsequent oral glucose tolerance test (OGTT) are at increased risk of delivering macrosomic and large for gestational age (LGA) neonates. We thus sought to evaluate t...
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Veröffentlicht in: | The journal of maternal-fetal & neonatal medicine 2008, Vol.21 (1), p.73-79 |
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container_title | The journal of maternal-fetal & neonatal medicine |
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creator | Segal, Phillip Hamilton, Jill K. Sermer, Mathew Connelly, Philip W. Hanley, Anthony J. G. Zinman, Bernard Retnakaran, Ravi |
description | Objective. Pregnant women with an abnormal screening glucose challenge test (GCT) but without gestational diabetes mellitus (GDM) on subsequent oral glucose tolerance test (OGTT) are at increased risk of delivering macrosomic and large for gestational age (LGA) neonates. We thus sought to evaluate the maternal constitutional and biochemical factors that determine infant birth weight in this patient population.
Methods. Women with an abnormal GCT were evaluated at the time of their OGTT in late pregnancy. This analysis was restricted to Caucasian women without GDM (N = 86). Maternal demographic and biochemical factors were evaluated in relation to infant birth weight and LGA.
Results. After adjustment for length of gestation, birth weight was positively associated with pre-pregnancy body mass index (BMI) (r = 0.31, p = 0.0063) and negatively correlated with maternal serum levels of the insulin-sensitizing protein adiponectin (r = −0.30, p = 0.0084). On multiple linear regression analysis, pre-pregnancy BMI and weight gain in pregnancy were positive independent determinants of infant birth weight, while family history of diabetes emerged as a negative independent correlate. Logistic regression analysis confirmed that pre-pregnancy BMI was a positive predictor of LGA (odds ratio (OR) = 1.25, 95% confidence interval (CI) 1.05-1.49), whereas family history of diabetes was again identified as a negative determinant (OR = 0.10, 95% CI 0.02-0.59). In contrast, neither measures of glycemia nor insulin resistance sensitivity were independently associated with birth weight or LGA.
Conclusion. In pregnant women with an abnormal GCT but without GDM, pre-gravid maternal obesity predicts increased infant birth weight, whereas family history of diabetes is independently associated with decreased infant size. |
doi_str_mv | 10.1080/14767050701827148 |
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Methods. Women with an abnormal GCT were evaluated at the time of their OGTT in late pregnancy. This analysis was restricted to Caucasian women without GDM (N = 86). Maternal demographic and biochemical factors were evaluated in relation to infant birth weight and LGA.
Results. After adjustment for length of gestation, birth weight was positively associated with pre-pregnancy body mass index (BMI) (r = 0.31, p = 0.0063) and negatively correlated with maternal serum levels of the insulin-sensitizing protein adiponectin (r = −0.30, p = 0.0084). On multiple linear regression analysis, pre-pregnancy BMI and weight gain in pregnancy were positive independent determinants of infant birth weight, while family history of diabetes emerged as a negative independent correlate. Logistic regression analysis confirmed that pre-pregnancy BMI was a positive predictor of LGA (odds ratio (OR) = 1.25, 95% confidence interval (CI) 1.05-1.49), whereas family history of diabetes was again identified as a negative determinant (OR = 0.10, 95% CI 0.02-0.59). In contrast, neither measures of glycemia nor insulin resistance sensitivity were independently associated with birth weight or LGA.
Conclusion. In pregnant women with an abnormal GCT but without GDM, pre-gravid maternal obesity predicts increased infant birth weight, whereas family history of diabetes is independently associated with decreased infant size.</description><identifier>ISSN: 1476-7058</identifier><identifier>EISSN: 1476-4954</identifier><identifier>DOI: 10.1080/14767050701827148</identifier><identifier>PMID: 18175247</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Adult ; Birth Weight ; Diabetes Mellitus - genetics ; Diabetes, Gestational ; Female ; Fetal Macrosomia ; Genetic Predisposition to Disease ; Glucose Intolerance ; glucose intolerance in pregnancy ; Glucose Tolerance Test ; Humans ; Infant, Newborn ; maternal obesity ; Obesity ; Odds Ratio ; Pregnancy</subject><ispartof>The journal of maternal-fetal & neonatal medicine, 2008, Vol.21 (1), p.73-79</ispartof><rights>2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-a0319925ff20deb424b524af000a37f1182ce66184255d2c4de1ac0d74d36ab93</citedby><cites>FETCH-LOGICAL-c404t-a0319925ff20deb424b524af000a37f1182ce66184255d2c4de1ac0d74d36ab93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/14767050701827148$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/14767050701827148$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18175247$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Segal, Phillip</creatorcontrib><creatorcontrib>Hamilton, Jill K.</creatorcontrib><creatorcontrib>Sermer, Mathew</creatorcontrib><creatorcontrib>Connelly, Philip W.</creatorcontrib><creatorcontrib>Hanley, Anthony J. G.</creatorcontrib><creatorcontrib>Zinman, Bernard</creatorcontrib><creatorcontrib>Retnakaran, Ravi</creatorcontrib><title>Maternal obesity and familial history of diabetes have opposing effects on infant birth weight in women with mild glucose intolerance in pregnancy</title><title>The journal of maternal-fetal & neonatal medicine</title><addtitle>J Matern Fetal Neonatal Med</addtitle><description>Objective. Pregnant women with an abnormal screening glucose challenge test (GCT) but without gestational diabetes mellitus (GDM) on subsequent oral glucose tolerance test (OGTT) are at increased risk of delivering macrosomic and large for gestational age (LGA) neonates. We thus sought to evaluate the maternal constitutional and biochemical factors that determine infant birth weight in this patient population.
Methods. Women with an abnormal GCT were evaluated at the time of their OGTT in late pregnancy. This analysis was restricted to Caucasian women without GDM (N = 86). Maternal demographic and biochemical factors were evaluated in relation to infant birth weight and LGA.
Results. After adjustment for length of gestation, birth weight was positively associated with pre-pregnancy body mass index (BMI) (r = 0.31, p = 0.0063) and negatively correlated with maternal serum levels of the insulin-sensitizing protein adiponectin (r = −0.30, p = 0.0084). On multiple linear regression analysis, pre-pregnancy BMI and weight gain in pregnancy were positive independent determinants of infant birth weight, while family history of diabetes emerged as a negative independent correlate. Logistic regression analysis confirmed that pre-pregnancy BMI was a positive predictor of LGA (odds ratio (OR) = 1.25, 95% confidence interval (CI) 1.05-1.49), whereas family history of diabetes was again identified as a negative determinant (OR = 0.10, 95% CI 0.02-0.59). In contrast, neither measures of glycemia nor insulin resistance sensitivity were independently associated with birth weight or LGA.
Conclusion. In pregnant women with an abnormal GCT but without GDM, pre-gravid maternal obesity predicts increased infant birth weight, whereas family history of diabetes is independently associated with decreased infant size.</description><subject>Adult</subject><subject>Birth Weight</subject><subject>Diabetes Mellitus - genetics</subject><subject>Diabetes, Gestational</subject><subject>Female</subject><subject>Fetal Macrosomia</subject><subject>Genetic Predisposition to Disease</subject><subject>Glucose Intolerance</subject><subject>glucose intolerance in pregnancy</subject><subject>Glucose Tolerance Test</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>maternal obesity</subject><subject>Obesity</subject><subject>Odds Ratio</subject><subject>Pregnancy</subject><issn>1476-7058</issn><issn>1476-4954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uc1u3CAYtKpGzU_7AL1UnHrbFGy8eNVeqij9kVLl0p7RZ_hYE2FwAWfl18gTF2tXqqpKucDHMDOCmap6y-g1ox39wLjYCtpSQVlXC8a7F9XFim34ruUvT3MhdOfVZUoPlNaM0_ZVdc46Jtqai4vq6QdkjB4cCT0mmxcCXhMDo3W2gINNOcSFBEO0hR4zJjLAI5IwTSFZvydoDKqcSPDEegM-k97GPJAD2v2QC0YOYcSy2gIWV032blYhYbnKwWEEr9aZTBH3vhyW19WZAZfwzWm_qn59uf15821zd__1-83nu43ilOcN0IbtdnVrTE019rzmffkSGEopNMKwEonC7ZZ1vG5bXSuukYGiWnDdbKHfNVfV-6PvFMPvGVOWo00KnQOPYU6ypCqE6EQhsiNRxZBSRCOnaEeIi2RUrkXI_4oomncn87kfUf9VnJIvhE9HQkktxBEOITotMywuRLOGYpNsnvP_-I98QHB5UBBRPoR5LTQ987o_HA2rXg</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Segal, Phillip</creator><creator>Hamilton, Jill K.</creator><creator>Sermer, Mathew</creator><creator>Connelly, Philip W.</creator><creator>Hanley, Anthony J. G.</creator><creator>Zinman, Bernard</creator><creator>Retnakaran, Ravi</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Maternal obesity and familial history of diabetes have opposing effects on infant birth weight in women with mild glucose intolerance in pregnancy</title><author>Segal, Phillip ; Hamilton, Jill K. ; Sermer, Mathew ; Connelly, Philip W. ; Hanley, Anthony J. G. ; Zinman, Bernard ; Retnakaran, Ravi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-a0319925ff20deb424b524af000a37f1182ce66184255d2c4de1ac0d74d36ab93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Birth Weight</topic><topic>Diabetes Mellitus - genetics</topic><topic>Diabetes, Gestational</topic><topic>Female</topic><topic>Fetal Macrosomia</topic><topic>Genetic Predisposition to Disease</topic><topic>Glucose Intolerance</topic><topic>glucose intolerance in pregnancy</topic><topic>Glucose Tolerance Test</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>maternal obesity</topic><topic>Obesity</topic><topic>Odds Ratio</topic><topic>Pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Segal, Phillip</creatorcontrib><creatorcontrib>Hamilton, Jill K.</creatorcontrib><creatorcontrib>Sermer, Mathew</creatorcontrib><creatorcontrib>Connelly, Philip W.</creatorcontrib><creatorcontrib>Hanley, Anthony J. G.</creatorcontrib><creatorcontrib>Zinman, Bernard</creatorcontrib><creatorcontrib>Retnakaran, Ravi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Segal, Phillip</au><au>Hamilton, Jill K.</au><au>Sermer, Mathew</au><au>Connelly, Philip W.</au><au>Hanley, Anthony J. G.</au><au>Zinman, Bernard</au><au>Retnakaran, Ravi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal obesity and familial history of diabetes have opposing effects on infant birth weight in women with mild glucose intolerance in pregnancy</atitle><jtitle>The journal of maternal-fetal & neonatal medicine</jtitle><addtitle>J Matern Fetal Neonatal Med</addtitle><date>2008</date><risdate>2008</risdate><volume>21</volume><issue>1</issue><spage>73</spage><epage>79</epage><pages>73-79</pages><issn>1476-7058</issn><eissn>1476-4954</eissn><abstract>Objective. Pregnant women with an abnormal screening glucose challenge test (GCT) but without gestational diabetes mellitus (GDM) on subsequent oral glucose tolerance test (OGTT) are at increased risk of delivering macrosomic and large for gestational age (LGA) neonates. We thus sought to evaluate the maternal constitutional and biochemical factors that determine infant birth weight in this patient population.
Methods. Women with an abnormal GCT were evaluated at the time of their OGTT in late pregnancy. This analysis was restricted to Caucasian women without GDM (N = 86). Maternal demographic and biochemical factors were evaluated in relation to infant birth weight and LGA.
Results. After adjustment for length of gestation, birth weight was positively associated with pre-pregnancy body mass index (BMI) (r = 0.31, p = 0.0063) and negatively correlated with maternal serum levels of the insulin-sensitizing protein adiponectin (r = −0.30, p = 0.0084). On multiple linear regression analysis, pre-pregnancy BMI and weight gain in pregnancy were positive independent determinants of infant birth weight, while family history of diabetes emerged as a negative independent correlate. Logistic regression analysis confirmed that pre-pregnancy BMI was a positive predictor of LGA (odds ratio (OR) = 1.25, 95% confidence interval (CI) 1.05-1.49), whereas family history of diabetes was again identified as a negative determinant (OR = 0.10, 95% CI 0.02-0.59). In contrast, neither measures of glycemia nor insulin resistance sensitivity were independently associated with birth weight or LGA.
Conclusion. In pregnant women with an abnormal GCT but without GDM, pre-gravid maternal obesity predicts increased infant birth weight, whereas family history of diabetes is independently associated with decreased infant size.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>18175247</pmid><doi>10.1080/14767050701827148</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Birth Weight Diabetes Mellitus - genetics Diabetes, Gestational Female Fetal Macrosomia Genetic Predisposition to Disease Glucose Intolerance glucose intolerance in pregnancy Glucose Tolerance Test Humans Infant, Newborn maternal obesity Obesity Odds Ratio Pregnancy |
title | Maternal obesity and familial history of diabetes have opposing effects on infant birth weight in women with mild glucose intolerance in pregnancy |
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