Inhibition of prostaglandin F(2alpha) by selective cyclooxygenase 2 inhibitors accounts for reduced rat leukocyte migration

To investigate whether selective COX 2 inhibitors (celecoxib, rofecoxib) would play a role in a model of leukocyte migration in rats. Bacterial endotoxin (Escherichia coli LPS) was intraperitoneally injected at time zero in rats that were previously treated with unspecific and selective cyclooxygena...

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Veröffentlicht in:	Inflammation 2005-12, Vol.29 (4-6), p.163-169
Hauptverfasser:	de Menezes, Gustavo Batista, dos Reis, Webster Glayser Pimenta, Santos, Júlia Maria Moreira, Duarte, Igor Dimitri Gama, de Francischi, Janetti Nogueira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Celecoxib Cyclooxygenase 2 - physiology Cyclooxygenase 2 Inhibitors - pharmacology Dinoprost - administration & dosage Dinoprost - antagonists & inhibitors Dinoprost - pharmacology Dinoprost - physiology Dinoprostone - administration & dosage Dinoprostone - pharmacology Dose-Response Relationship, Drug Female Indomethacin - pharmacology Injections, Intraperitoneal Lactones - pharmacology Lipopolysaccharides - administration & dosage Lipopolysaccharides - pharmacology Neutrophil Infiltration - drug effects Neutrophil Infiltration - physiology Pyrazoles - pharmacology Rats Rats, Sprague-Dawley Sulfonamides - pharmacology Sulfones - pharmacology Time Factors
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