C-reactive protein and the mode of onset of labor in term pregnancies
Objective. To evaluate whether C-reactive protein (CRP) levels in maternal serum at post-date follow-up can predict the mode of onset of spontaneous delivery in term pregnancies and the interval to delivery. Study design. Women at 40 completed weeks of gestation were recruited. The interval from CRP...
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container_title | Acta obstetricia et gynecologica Scandinavica |
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creator | Wiser, Amir Sivan, Eyal Dulitzki, Moti Chayen, Benjemin Schiff, Eyal Bar-Chaim, Adina Simchen, Michal J. |
description | Objective. To evaluate whether C-reactive protein (CRP) levels in maternal serum at post-date follow-up can predict the mode of onset of spontaneous delivery in term pregnancies and the interval to delivery. Study design. Women at 40 completed weeks of gestation were recruited. The interval from CRP sampling to delivery and mode of onset of delivery were noted. Results. Sixty women were divided into 3 groups according to the mode of onset of labor. Group A presented with spontaneous onset of contractions, Group B presented with pre-labor ruptured membranes (PROM), and Group C completed 42 weeks without spontaneous initiation of labor. There was no association between CRP values and latency from time of sampling to delivery. Mean serum CRP in Group B (12.7 mg/l) was significantly higher than in either Group A (7.2 mg/l) or Group C (10.2 mg/l) (p=0.01). In addition, CRP values in the upper quartile (>12.2 mg/l) had a 37.5% positive predictive value for PROM, with a negative predictive value of 93%. Conclusion. Women whose labor will start with PROM have higher CRP values at post-date follow-up than women whose labor starts otherwise. |
doi_str_mv | 10.1080/00016340701714661 |
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To evaluate whether C-reactive protein (CRP) levels in maternal serum at post-date follow-up can predict the mode of onset of spontaneous delivery in term pregnancies and the interval to delivery. Study design. Women at 40 completed weeks of gestation were recruited. The interval from CRP sampling to delivery and mode of onset of delivery were noted. Results. Sixty women were divided into 3 groups according to the mode of onset of labor. Group A presented with spontaneous onset of contractions, Group B presented with pre-labor ruptured membranes (PROM), and Group C completed 42 weeks without spontaneous initiation of labor. There was no association between CRP values and latency from time of sampling to delivery. Mean serum CRP in Group B (12.7 mg/l) was significantly higher than in either Group A (7.2 mg/l) or Group C (10.2 mg/l) (p=0.01). In addition, CRP values in the upper quartile (>12.2 mg/l) had a 37.5% positive predictive value for PROM, with a negative predictive value of 93%. Conclusion. Women whose labor will start with PROM have higher CRP values at post-date follow-up than women whose labor starts otherwise.</description><identifier>ISSN: 0001-6349</identifier><identifier>EISSN: 1600-0412</identifier><identifier>DOI: 10.1080/00016340701714661</identifier><identifier>PMID: 17943468</identifier><identifier>CODEN: AOGSAE</identifier><language>eng</language><publisher>Oxford, UK: Informa UK Ltd</publisher><subject>Adult ; Biological and medical sciences ; Birth Weight ; C-Reactive Protein - physiology ; CRP ; Delivery. Postpartum. Lactation ; Diseases of mother, fetus and pregnancy ; Disorders ; Female ; Fetal Membranes, Premature Rupture - blood ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; Labor Onset - blood ; Labor Onset - physiology ; Medical sciences ; mode of labor ; Pregnancy ; Pregnancy. Fetus. Placenta ; term pregnancy</subject><ispartof>Acta obstetricia et gynecologica Scandinavica, 2008, Vol.87 (1), p.26-30</ispartof><rights>2008 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2008</rights><rights>Acta Obstet Gynecol Scand 2008</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5080-328689214fdaa53d7e4243088d3876575ed1e16cc83eb121152cb5ceb08f015c3</citedby><cites>FETCH-LOGICAL-c5080-328689214fdaa53d7e4243088d3876575ed1e16cc83eb121152cb5ceb08f015c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1080%2F00016340701714661$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1080%2F00016340701714661$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20002479$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17943468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wiser, Amir</creatorcontrib><creatorcontrib>Sivan, Eyal</creatorcontrib><creatorcontrib>Dulitzki, Moti</creatorcontrib><creatorcontrib>Chayen, Benjemin</creatorcontrib><creatorcontrib>Schiff, Eyal</creatorcontrib><creatorcontrib>Bar-Chaim, Adina</creatorcontrib><creatorcontrib>Simchen, Michal J.</creatorcontrib><title>C-reactive protein and the mode of onset of labor in term pregnancies</title><title>Acta obstetricia et gynecologica Scandinavica</title><addtitle>Acta Obstet Gynecol Scand</addtitle><description>Objective. To evaluate whether C-reactive protein (CRP) levels in maternal serum at post-date follow-up can predict the mode of onset of spontaneous delivery in term pregnancies and the interval to delivery. Study design. Women at 40 completed weeks of gestation were recruited. The interval from CRP sampling to delivery and mode of onset of delivery were noted. Results. Sixty women were divided into 3 groups according to the mode of onset of labor. Group A presented with spontaneous onset of contractions, Group B presented with pre-labor ruptured membranes (PROM), and Group C completed 42 weeks without spontaneous initiation of labor. There was no association between CRP values and latency from time of sampling to delivery. Mean serum CRP in Group B (12.7 mg/l) was significantly higher than in either Group A (7.2 mg/l) or Group C (10.2 mg/l) (p=0.01). In addition, CRP values in the upper quartile (>12.2 mg/l) had a 37.5% positive predictive value for PROM, with a negative predictive value of 93%. Conclusion. Women whose labor will start with PROM have higher CRP values at post-date follow-up than women whose labor starts otherwise.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>C-Reactive Protein - physiology</subject><subject>CRP</subject><subject>Delivery. Postpartum. Lactation</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Disorders</subject><subject>Female</subject><subject>Fetal Membranes, Premature Rupture - blood</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Labor Onset - blood</subject><subject>Labor Onset - physiology</subject><subject>Medical sciences</subject><subject>mode of labor</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>term pregnancy</subject><issn>0001-6349</issn><issn>1600-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi1ERZeFH8AF5QK3UI-_I07VqiyoVSshPo6W40zYlCRu7SzQf19HG5UDUjnZ1jzvOzOvCXkF9B1QQ08opaC4oJqCBqEUPCErUJSWVAB7SlZzvcxAdUyep3SdX0wL84wcg64EF8qsyNmmjOj81P3C4iaGCbuxcGNTTDsshtBgEdoijAmn-dK7OsQiExPGIeP4Y3Sj7zC9IEet6xO-XM41-frh7MvmY3lxtf20Ob0ovczzlpwZZSoGom2ck7zRKJjg1JiGG62kltgAgvLecKyBAUjma-mxpqalID1fk7cH3zzq7R7TZIcueex7N2LYJzsHoXn2XBM4gD6GlCK29iZ2g4t3Fqids7P_ZJc1rxfzfT1g81exhJWBNwvgknd9G-fl0wPHsiUTusqcPHC_ux7v_t_Znl5tFdCsKw-6Lk3450Hn4k-rNNfSfr_c2ur82-VnXhl7nvn3Cz-2IQ5uh66fdt5FtNdhH8f8E4-sew8IcqRf</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Wiser, Amir</creator><creator>Sivan, Eyal</creator><creator>Dulitzki, Moti</creator><creator>Chayen, Benjemin</creator><creator>Schiff, Eyal</creator><creator>Bar-Chaim, Adina</creator><creator>Simchen, Michal J.</creator><general>Informa UK Ltd</general><general>Blackwell Publishing Ltd</general><general>Taylor & Francis</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>C-reactive protein and the mode of onset of labor in term pregnancies</title><author>Wiser, Amir ; Sivan, Eyal ; Dulitzki, Moti ; Chayen, Benjemin ; Schiff, Eyal ; Bar-Chaim, Adina ; Simchen, Michal J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5080-328689214fdaa53d7e4243088d3876575ed1e16cc83eb121152cb5ceb08f015c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>C-Reactive Protein - physiology</topic><topic>CRP</topic><topic>Delivery. Postpartum. Lactation</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Disorders</topic><topic>Female</topic><topic>Fetal Membranes, Premature Rupture - blood</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Labor Onset - blood</topic><topic>Labor Onset - physiology</topic><topic>Medical sciences</topic><topic>mode of labor</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>term pregnancy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wiser, Amir</creatorcontrib><creatorcontrib>Sivan, Eyal</creatorcontrib><creatorcontrib>Dulitzki, Moti</creatorcontrib><creatorcontrib>Chayen, Benjemin</creatorcontrib><creatorcontrib>Schiff, Eyal</creatorcontrib><creatorcontrib>Bar-Chaim, Adina</creatorcontrib><creatorcontrib>Simchen, Michal J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wiser, Amir</au><au>Sivan, Eyal</au><au>Dulitzki, Moti</au><au>Chayen, Benjemin</au><au>Schiff, Eyal</au><au>Bar-Chaim, Adina</au><au>Simchen, Michal J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C-reactive protein and the mode of onset of labor in term pregnancies</atitle><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle><addtitle>Acta Obstet Gynecol Scand</addtitle><date>2008</date><risdate>2008</risdate><volume>87</volume><issue>1</issue><spage>26</spage><epage>30</epage><pages>26-30</pages><issn>0001-6349</issn><eissn>1600-0412</eissn><coden>AOGSAE</coden><abstract>Objective. To evaluate whether C-reactive protein (CRP) levels in maternal serum at post-date follow-up can predict the mode of onset of spontaneous delivery in term pregnancies and the interval to delivery. Study design. Women at 40 completed weeks of gestation were recruited. The interval from CRP sampling to delivery and mode of onset of delivery were noted. Results. Sixty women were divided into 3 groups according to the mode of onset of labor. Group A presented with spontaneous onset of contractions, Group B presented with pre-labor ruptured membranes (PROM), and Group C completed 42 weeks without spontaneous initiation of labor. There was no association between CRP values and latency from time of sampling to delivery. Mean serum CRP in Group B (12.7 mg/l) was significantly higher than in either Group A (7.2 mg/l) or Group C (10.2 mg/l) (p=0.01). In addition, CRP values in the upper quartile (>12.2 mg/l) had a 37.5% positive predictive value for PROM, with a negative predictive value of 93%. Conclusion. Women whose labor will start with PROM have higher CRP values at post-date follow-up than women whose labor starts otherwise.</abstract><cop>Oxford, UK</cop><pub>Informa UK Ltd</pub><pmid>17943468</pmid><doi>10.1080/00016340701714661</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Biological and medical sciences Birth Weight C-Reactive Protein - physiology CRP Delivery. Postpartum. Lactation Diseases of mother, fetus and pregnancy Disorders Female Fetal Membranes, Premature Rupture - blood Gestational Age Gynecology. Andrology. Obstetrics Humans Infant, Newborn Labor Onset - blood Labor Onset - physiology Medical sciences mode of labor Pregnancy Pregnancy. Fetus. Placenta term pregnancy |
title | C-reactive protein and the mode of onset of labor in term pregnancies |
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