The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy
The purpose of this study was to analyze the expression of the two proinflammatory cytokines IL-20 and IL-24 and their shared receptors in rheumatoid arthritis and spondyloarthropathy. IL-20 was increased in plasma of rheumatoid arthritis patients compared with osteoarthritis patients and IL-24 was...
Gespeichert in:
| Veröffentlicht in: | Cytokine (Philadelphia, Pa.) Pa.), 2008, Vol.41 (1), p.16-23 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 23 |
|---|---|
| container_issue | 1 |
| container_start_page | 16 |
| container_title | Cytokine (Philadelphia, Pa.) |
| container_volume | 41 |
| creator | Kragstrup, Tue Wenzel Otkjaer, Kristian Holm, Christian Jørgensen, Annette Hokland, Marianne Iversen, Lars Deleuran, Bent |
| description | The purpose of this study was to analyze the expression of the two proinflammatory cytokines IL-20 and IL-24 and their shared receptors in rheumatoid arthritis and spondyloarthropathy. IL-20 was increased in plasma of rheumatoid arthritis patients compared with osteoarthritis patients and IL-24 was increased in synovial fluid and plasma of rheumatoid arthritis and spondyloarthropathy patients compared with osteoarthritis patients. IL-20 and IL-24 mRNA was only present at low levels in the synovium. In the synovial membrane, IL-20 protein was present in mononuclear cells and neutrophil granulocytes whereas IL-24 protein was observed in endothelial cells and mononuclear cells. IL-20 receptor type 1 and IL-22 receptor were expressed by granulocytes in the synovial fluid. In synovial fluid mononuclear cell cultures, stimulation with recombinant human IL-20 or recombinant human IL-24 induced monocyte chemoattractant protein 1 (CCL2/MCP-1) secretion, but not tumour necrosis factor α mRNA synthesis or IL-6 secretion. Both IL-20 and IL-24 showed correlations to CCL2/MCP-1 in plasma from rheumatoid arthritis and spondyloarthropathy patients. This study associates IL-20 and IL-24 to the synovium of rheumatoid arthritis and spondyloarthropathy and results indicate that the two cytokines contribute to disease pathogenesis through recruitment of neutrophil granulocytes and induction of CCL2/MCP-1. |
| doi_str_mv | 10.1016/j.cyto.2007.10.004 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70177290</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1043466607004383</els_id><sourcerecordid>21236381</sourcerecordid><originalsourceid>FETCH-LOGICAL-c429t-cb0e2f4caebf89719ada72daca748948aaacfc2d7d942b0aa9f6b6dc0602ab1d3</originalsourceid><addsrcrecordid>eNqFkUGP0zAQhS0EYpeFP8AB5cQtZexYdixxQSsWVqrEZTlbE3uiuGrjYLuI8utx2krc4OTnN2_eYT7G3nLYcODqw27jTiVuBICuxgZAPmO3HIxqAUT3fNWya6VS6oa9ynkHAKbT-iW74T0oLrW8Zb-fJmro15Io5xDnJo7N47YV0ODsz0qeVZkopCZPmMg3iRwtJabc1G8TZpcIc_XD3KSJjgcsMfg6K1MKJeRzQV7i7E_7eHbjgmU6vWYvRtxnenN979j3h89P91_b7bcvj_eftq2TwpTWDUBilA5pGHujuUGPWnh0qGVvZI-IbnTCa2-kGADRjGpQ3oECgQP33R17f-ldUvxxpFzsIWRH-z3OFI_ZauBaCwP_DQouOtX1vAbFJehSzDnRaJcUDphOloNd0didXdHYFc3qVTR16d21_TgcyP9dubKogY-XANVj_AyUbHaBZkc-1IsX62P4V_8fZA-iOg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21236381</pqid></control><display><type>article</type><title>The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Kragstrup, Tue Wenzel ; Otkjaer, Kristian ; Holm, Christian ; Jørgensen, Annette ; Hokland, Marianne ; Iversen, Lars ; Deleuran, Bent</creator><creatorcontrib>Kragstrup, Tue Wenzel ; Otkjaer, Kristian ; Holm, Christian ; Jørgensen, Annette ; Hokland, Marianne ; Iversen, Lars ; Deleuran, Bent</creatorcontrib><description>The purpose of this study was to analyze the expression of the two proinflammatory cytokines IL-20 and IL-24 and their shared receptors in rheumatoid arthritis and spondyloarthropathy. IL-20 was increased in plasma of rheumatoid arthritis patients compared with osteoarthritis patients and IL-24 was increased in synovial fluid and plasma of rheumatoid arthritis and spondyloarthropathy patients compared with osteoarthritis patients. IL-20 and IL-24 mRNA was only present at low levels in the synovium. In the synovial membrane, IL-20 protein was present in mononuclear cells and neutrophil granulocytes whereas IL-24 protein was observed in endothelial cells and mononuclear cells. IL-20 receptor type 1 and IL-22 receptor were expressed by granulocytes in the synovial fluid. In synovial fluid mononuclear cell cultures, stimulation with recombinant human IL-20 or recombinant human IL-24 induced monocyte chemoattractant protein 1 (CCL2/MCP-1) secretion, but not tumour necrosis factor α mRNA synthesis or IL-6 secretion. Both IL-20 and IL-24 showed correlations to CCL2/MCP-1 in plasma from rheumatoid arthritis and spondyloarthropathy patients. This study associates IL-20 and IL-24 to the synovium of rheumatoid arthritis and spondyloarthropathy and results indicate that the two cytokines contribute to disease pathogenesis through recruitment of neutrophil granulocytes and induction of CCL2/MCP-1.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/j.cyto.2007.10.004</identifier><identifier>PMID: 18061474</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; Aged ; Arthritis ; Arthritis, Rheumatoid - metabolism ; Arthritis, Rheumatoid - pathology ; Cells, Cultured ; Chemokine CCL2 - biosynthesis ; Endothelial Cells - metabolism ; Endothelial Cells - pathology ; Female ; Humans ; IL-20 ; IL-24 ; Interleukins - biosynthesis ; Interleukins - pharmacology ; Leukocytes, Mononuclear - pathology ; Male ; Middle Aged ; Neutrophils - metabolism ; Neutrophils - pathology ; Osteoarthritis - metabolism ; Osteoarthritis - pathology ; Receptors, Interleukin - biosynthesis ; Spondylarthropathies - metabolism ; Spondylarthropathies - pathology ; Synovial Fluid - metabolism</subject><ispartof>Cytokine (Philadelphia, Pa.), 2008, Vol.41 (1), p.16-23</ispartof><rights>2007 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-cb0e2f4caebf89719ada72daca748948aaacfc2d7d942b0aa9f6b6dc0602ab1d3</citedby><cites>FETCH-LOGICAL-c429t-cb0e2f4caebf89719ada72daca748948aaacfc2d7d942b0aa9f6b6dc0602ab1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1043466607004383$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18061474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kragstrup, Tue Wenzel</creatorcontrib><creatorcontrib>Otkjaer, Kristian</creatorcontrib><creatorcontrib>Holm, Christian</creatorcontrib><creatorcontrib>Jørgensen, Annette</creatorcontrib><creatorcontrib>Hokland, Marianne</creatorcontrib><creatorcontrib>Iversen, Lars</creatorcontrib><creatorcontrib>Deleuran, Bent</creatorcontrib><title>The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>The purpose of this study was to analyze the expression of the two proinflammatory cytokines IL-20 and IL-24 and their shared receptors in rheumatoid arthritis and spondyloarthropathy. IL-20 was increased in plasma of rheumatoid arthritis patients compared with osteoarthritis patients and IL-24 was increased in synovial fluid and plasma of rheumatoid arthritis and spondyloarthropathy patients compared with osteoarthritis patients. IL-20 and IL-24 mRNA was only present at low levels in the synovium. In the synovial membrane, IL-20 protein was present in mononuclear cells and neutrophil granulocytes whereas IL-24 protein was observed in endothelial cells and mononuclear cells. IL-20 receptor type 1 and IL-22 receptor were expressed by granulocytes in the synovial fluid. In synovial fluid mononuclear cell cultures, stimulation with recombinant human IL-20 or recombinant human IL-24 induced monocyte chemoattractant protein 1 (CCL2/MCP-1) secretion, but not tumour necrosis factor α mRNA synthesis or IL-6 secretion. Both IL-20 and IL-24 showed correlations to CCL2/MCP-1 in plasma from rheumatoid arthritis and spondyloarthropathy patients. This study associates IL-20 and IL-24 to the synovium of rheumatoid arthritis and spondyloarthropathy and results indicate that the two cytokines contribute to disease pathogenesis through recruitment of neutrophil granulocytes and induction of CCL2/MCP-1.</description><subject>Adult</subject><subject>Aged</subject><subject>Arthritis</subject><subject>Arthritis, Rheumatoid - metabolism</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Cells, Cultured</subject><subject>Chemokine CCL2 - biosynthesis</subject><subject>Endothelial Cells - metabolism</subject><subject>Endothelial Cells - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>IL-20</subject><subject>IL-24</subject><subject>Interleukins - biosynthesis</subject><subject>Interleukins - pharmacology</subject><subject>Leukocytes, Mononuclear - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neutrophils - metabolism</subject><subject>Neutrophils - pathology</subject><subject>Osteoarthritis - metabolism</subject><subject>Osteoarthritis - pathology</subject><subject>Receptors, Interleukin - biosynthesis</subject><subject>Spondylarthropathies - metabolism</subject><subject>Spondylarthropathies - pathology</subject><subject>Synovial Fluid - metabolism</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGP0zAQhS0EYpeFP8AB5cQtZexYdixxQSsWVqrEZTlbE3uiuGrjYLuI8utx2krc4OTnN2_eYT7G3nLYcODqw27jTiVuBICuxgZAPmO3HIxqAUT3fNWya6VS6oa9ynkHAKbT-iW74T0oLrW8Zb-fJmro15Io5xDnJo7N47YV0ODsz0qeVZkopCZPmMg3iRwtJabc1G8TZpcIc_XD3KSJjgcsMfg6K1MKJeRzQV7i7E_7eHbjgmU6vWYvRtxnenN979j3h89P91_b7bcvj_eftq2TwpTWDUBilA5pGHujuUGPWnh0qGVvZI-IbnTCa2-kGADRjGpQ3oECgQP33R17f-ldUvxxpFzsIWRH-z3OFI_ZauBaCwP_DQouOtX1vAbFJehSzDnRaJcUDphOloNd0didXdHYFc3qVTR16d21_TgcyP9dubKogY-XANVj_AyUbHaBZkc-1IsX62P4V_8fZA-iOg</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Kragstrup, Tue Wenzel</creator><creator>Otkjaer, Kristian</creator><creator>Holm, Christian</creator><creator>Jørgensen, Annette</creator><creator>Hokland, Marianne</creator><creator>Iversen, Lars</creator><creator>Deleuran, Bent</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy</title><author>Kragstrup, Tue Wenzel ; Otkjaer, Kristian ; Holm, Christian ; Jørgensen, Annette ; Hokland, Marianne ; Iversen, Lars ; Deleuran, Bent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-cb0e2f4caebf89719ada72daca748948aaacfc2d7d942b0aa9f6b6dc0602ab1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arthritis</topic><topic>Arthritis, Rheumatoid - metabolism</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Cells, Cultured</topic><topic>Chemokine CCL2 - biosynthesis</topic><topic>Endothelial Cells - metabolism</topic><topic>Endothelial Cells - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>IL-20</topic><topic>IL-24</topic><topic>Interleukins - biosynthesis</topic><topic>Interleukins - pharmacology</topic><topic>Leukocytes, Mononuclear - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neutrophils - metabolism</topic><topic>Neutrophils - pathology</topic><topic>Osteoarthritis - metabolism</topic><topic>Osteoarthritis - pathology</topic><topic>Receptors, Interleukin - biosynthesis</topic><topic>Spondylarthropathies - metabolism</topic><topic>Spondylarthropathies - pathology</topic><topic>Synovial Fluid - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kragstrup, Tue Wenzel</creatorcontrib><creatorcontrib>Otkjaer, Kristian</creatorcontrib><creatorcontrib>Holm, Christian</creatorcontrib><creatorcontrib>Jørgensen, Annette</creatorcontrib><creatorcontrib>Hokland, Marianne</creatorcontrib><creatorcontrib>Iversen, Lars</creatorcontrib><creatorcontrib>Deleuran, Bent</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kragstrup, Tue Wenzel</au><au>Otkjaer, Kristian</au><au>Holm, Christian</au><au>Jørgensen, Annette</au><au>Hokland, Marianne</au><au>Iversen, Lars</au><au>Deleuran, Bent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><addtitle>Cytokine</addtitle><date>2008</date><risdate>2008</risdate><volume>41</volume><issue>1</issue><spage>16</spage><epage>23</epage><pages>16-23</pages><issn>1043-4666</issn><eissn>1096-0023</eissn><abstract>The purpose of this study was to analyze the expression of the two proinflammatory cytokines IL-20 and IL-24 and their shared receptors in rheumatoid arthritis and spondyloarthropathy. IL-20 was increased in plasma of rheumatoid arthritis patients compared with osteoarthritis patients and IL-24 was increased in synovial fluid and plasma of rheumatoid arthritis and spondyloarthropathy patients compared with osteoarthritis patients. IL-20 and IL-24 mRNA was only present at low levels in the synovium. In the synovial membrane, IL-20 protein was present in mononuclear cells and neutrophil granulocytes whereas IL-24 protein was observed in endothelial cells and mononuclear cells. IL-20 receptor type 1 and IL-22 receptor were expressed by granulocytes in the synovial fluid. In synovial fluid mononuclear cell cultures, stimulation with recombinant human IL-20 or recombinant human IL-24 induced monocyte chemoattractant protein 1 (CCL2/MCP-1) secretion, but not tumour necrosis factor α mRNA synthesis or IL-6 secretion. Both IL-20 and IL-24 showed correlations to CCL2/MCP-1 in plasma from rheumatoid arthritis and spondyloarthropathy patients. This study associates IL-20 and IL-24 to the synovium of rheumatoid arthritis and spondyloarthropathy and results indicate that the two cytokines contribute to disease pathogenesis through recruitment of neutrophil granulocytes and induction of CCL2/MCP-1.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>18061474</pmid><doi>10.1016/j.cyto.2007.10.004</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-4666 |
| ispartof | Cytokine (Philadelphia, Pa.), 2008, Vol.41 (1), p.16-23 |
| issn | 1043-4666 1096-0023 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70177290 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Arthritis Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Cells, Cultured Chemokine CCL2 - biosynthesis Endothelial Cells - metabolism Endothelial Cells - pathology Female Humans IL-20 IL-24 Interleukins - biosynthesis Interleukins - pharmacology Leukocytes, Mononuclear - pathology Male Middle Aged Neutrophils - metabolism Neutrophils - pathology Osteoarthritis - metabolism Osteoarthritis - pathology Receptors, Interleukin - biosynthesis Spondylarthropathies - metabolism Spondylarthropathies - pathology Synovial Fluid - metabolism |
| title | The expression of IL-20 and IL-24 and their shared receptors are increased in rheumatoid arthritis and spondyloarthropathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T18%3A00%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20expression%20of%20IL-20%20and%20IL-24%20and%20their%20shared%20receptors%20are%20increased%20in%20rheumatoid%20arthritis%20and%20spondyloarthropathy&rft.jtitle=Cytokine%20(Philadelphia,%20Pa.)&rft.au=Kragstrup,%20Tue%20Wenzel&rft.date=2008&rft.volume=41&rft.issue=1&rft.spage=16&rft.epage=23&rft.pages=16-23&rft.issn=1043-4666&rft.eissn=1096-0023&rft_id=info:doi/10.1016/j.cyto.2007.10.004&rft_dat=%3Cproquest_cross%3E21236381%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21236381&rft_id=info:pmid/18061474&rft_els_id=S1043466607004383&rfr_iscdi=true |