Vascular Endothelial Growth Factor Gene Polymorphisms Associated with Prognosis for Patients with Colorectal Cancer
Purpose: Vascular endothelial growth factor (VEGF) or its family may be considered to play an important role in lymphangiogenesis and lymphatic tumor spread, thereby affecting prognosis of colorectal cancer. Accordingly, the present study analyzed VEGF gene polymorphisms and their effect on the prog...
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| Veröffentlicht in: | Clinical cancer research 2008-01, Vol.14 (1), p.62-66 |
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| container_title | Clinical cancer research |
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| creator | Kim, Jong Gwang Chae, Yee Soo Sohn, Sang Kyun Cho, Yoon Young Moon, Joon Ho Park, Jae Yong Jeon, Seoung Woo Lee, In Taek Choi, Gyu Seog Jun, Soo-Han |
| description | Purpose: Vascular endothelial growth factor (VEGF) or its family may be considered to play an important role in lymphangiogenesis
and lymphatic tumor spread, thereby affecting prognosis of colorectal cancer. Accordingly, the present study analyzed VEGF gene polymorphisms and their effect on the prognosis for patients with colorectal cancer.
Experimental Design: Four hundred and forty-five consecutive patients with surgically treated colorectal adenocarcinoma were enrolled in the present
study. The genomic DNA was extracted from fresh colorectal tissue and three VEGF (−2578C>A, −634G>C, and +936C>T) gene polymorphisms were determined using a PCR/denaturing high-performance liquid chromatography
assay.
Results: Multivariate survival analysis showed that the survival for the patients with the −634 G/C genotype [overall survival (OS):
hazard ratio (HR), 0.158; P < 0.001] or C/C genotype (OS: HR, 0.188; P < 0.001) were better than for the patients with the −634G/G genotype, whereas the +936 C/T genotype (OS: HR, 12.809; P < 0.001) or T/T genotype (OS: HR, 37.260; P < 0.001) was associated with a worse survival compared with the +936 C/C genotype. In haplotype analysis, the −2578A/−634G/+936T
haplotype exhibited a significantly worse survival when compared with the wild −2578C/−634G/+936C haplotype (OS: HR, 3.866;
P < 0.001).
Conclusions: VEGF gene polymorphisms were found to be an independent prognostic marker for patients with colorectal cancer. Accordingly, the
analysis of VEGF gene polymorphisms can help identify patient subgroups at high risk of a poor disease outcome. |
| doi_str_mv | 10.1158/1078-0432.CCR-07-1537 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70177129</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70177129</sourcerecordid><originalsourceid>FETCH-LOGICAL-c446t-2375dd5d528dcb417e79c2c1e3862ac5978dbb6534bd210268381203a8f804773</originalsourceid><addsrcrecordid>eNqFkc1u1DAURi0EoqXwCKBsYJfi65_YWVZROyBVYoSAreXYTmOUxINvRqO-PR5moEtWtuTzXV99h5C3QK8BpP4IVOmaCs6uu-5rTVUNkqtn5BKkVDVnjXxe7n-ZC_IK8SelIICKl-QCNCjGJL8k-MOi2082V7eLT-sYpminapPTYR2rO-vWlKtNWEK1TdPjnPJujDhjdYOYXLRr8NUhFnKb08OSMGI1lMDWrjEsK57eujSlHNxa5nZ2cSG_Ji8GO2F4cz6vyPe722_dp_r-y-Zzd3NfOyGatWZcSe-ll0x71wtQQbWOOQhcN8w62Srt-76RXPSeAWWN5hoY5VYPmgql-BX5cJq7y-nXPuBq5oguTJNdQtqjURSUAtb-F2S0ZUy0uoDyBLqcEHMYzC7H2eZHA9QctZhj5eZYuSlaDFXmqKXk3p0_2Pdz8E-ps4cCvD8DRYedhlyKiviPY8Vc8cqfNh3jw3iIORj3p9IcMNjsRgPCgGkY_w0pUqOY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20922498</pqid></control><display><type>article</type><title>Vascular Endothelial Growth Factor Gene Polymorphisms Associated with Prognosis for Patients with Colorectal Cancer</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Kim, Jong Gwang ; Chae, Yee Soo ; Sohn, Sang Kyun ; Cho, Yoon Young ; Moon, Joon Ho ; Park, Jae Yong ; Jeon, Seoung Woo ; Lee, In Taek ; Choi, Gyu Seog ; Jun, Soo-Han</creator><creatorcontrib>Kim, Jong Gwang ; Chae, Yee Soo ; Sohn, Sang Kyun ; Cho, Yoon Young ; Moon, Joon Ho ; Park, Jae Yong ; Jeon, Seoung Woo ; Lee, In Taek ; Choi, Gyu Seog ; Jun, Soo-Han</creatorcontrib><description>Purpose: Vascular endothelial growth factor (VEGF) or its family may be considered to play an important role in lymphangiogenesis
and lymphatic tumor spread, thereby affecting prognosis of colorectal cancer. Accordingly, the present study analyzed VEGF gene polymorphisms and their effect on the prognosis for patients with colorectal cancer.
Experimental Design: Four hundred and forty-five consecutive patients with surgically treated colorectal adenocarcinoma were enrolled in the present
study. The genomic DNA was extracted from fresh colorectal tissue and three VEGF (−2578C>A, −634G>C, and +936C>T) gene polymorphisms were determined using a PCR/denaturing high-performance liquid chromatography
assay.
Results: Multivariate survival analysis showed that the survival for the patients with the −634 G/C genotype [overall survival (OS):
hazard ratio (HR), 0.158; P < 0.001] or C/C genotype (OS: HR, 0.188; P < 0.001) were better than for the patients with the −634G/G genotype, whereas the +936 C/T genotype (OS: HR, 12.809; P < 0.001) or T/T genotype (OS: HR, 37.260; P < 0.001) was associated with a worse survival compared with the +936 C/C genotype. In haplotype analysis, the −2578A/−634G/+936T
haplotype exhibited a significantly worse survival when compared with the wild −2578C/−634G/+936C haplotype (OS: HR, 3.866;
P < 0.001).
Conclusions: VEGF gene polymorphisms were found to be an independent prognostic marker for patients with colorectal cancer. Accordingly, the
analysis of VEGF gene polymorphisms can help identify patient subgroups at high risk of a poor disease outcome.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>DOI: 10.1158/1078-0432.CCR-07-1537</identifier><identifier>PMID: 18172253</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adenocarcinoma - genetics ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic agents ; Biological and medical sciences ; Biomarkers, Tumor - genetics ; Chromatography, High Pressure Liquid ; colorectal cancer ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; gene ; Genotype ; Haplotypes ; Humans ; Kaplan-Meier Estimate ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Polymerase Chain Reaction ; polymorphism ; Polymorphism, Single Nucleotide ; Prognosis ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Survival Analysis ; Tumors ; Vascular Endothelial Growth Factor A - genetics ; VEGF</subject><ispartof>Clinical cancer research, 2008-01, Vol.14 (1), p.62-66</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-2375dd5d528dcb417e79c2c1e3862ac5978dbb6534bd210268381203a8f804773</citedby><cites>FETCH-LOGICAL-c446t-2375dd5d528dcb417e79c2c1e3862ac5978dbb6534bd210268381203a8f804773</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,3355,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20145573$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18172253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jong Gwang</creatorcontrib><creatorcontrib>Chae, Yee Soo</creatorcontrib><creatorcontrib>Sohn, Sang Kyun</creatorcontrib><creatorcontrib>Cho, Yoon Young</creatorcontrib><creatorcontrib>Moon, Joon Ho</creatorcontrib><creatorcontrib>Park, Jae Yong</creatorcontrib><creatorcontrib>Jeon, Seoung Woo</creatorcontrib><creatorcontrib>Lee, In Taek</creatorcontrib><creatorcontrib>Choi, Gyu Seog</creatorcontrib><creatorcontrib>Jun, Soo-Han</creatorcontrib><title>Vascular Endothelial Growth Factor Gene Polymorphisms Associated with Prognosis for Patients with Colorectal Cancer</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Purpose: Vascular endothelial growth factor (VEGF) or its family may be considered to play an important role in lymphangiogenesis
and lymphatic tumor spread, thereby affecting prognosis of colorectal cancer. Accordingly, the present study analyzed VEGF gene polymorphisms and their effect on the prognosis for patients with colorectal cancer.
Experimental Design: Four hundred and forty-five consecutive patients with surgically treated colorectal adenocarcinoma were enrolled in the present
study. The genomic DNA was extracted from fresh colorectal tissue and three VEGF (−2578C>A, −634G>C, and +936C>T) gene polymorphisms were determined using a PCR/denaturing high-performance liquid chromatography
assay.
Results: Multivariate survival analysis showed that the survival for the patients with the −634 G/C genotype [overall survival (OS):
hazard ratio (HR), 0.158; P < 0.001] or C/C genotype (OS: HR, 0.188; P < 0.001) were better than for the patients with the −634G/G genotype, whereas the +936 C/T genotype (OS: HR, 12.809; P < 0.001) or T/T genotype (OS: HR, 37.260; P < 0.001) was associated with a worse survival compared with the +936 C/C genotype. In haplotype analysis, the −2578A/−634G/+936T
haplotype exhibited a significantly worse survival when compared with the wild −2578C/−634G/+936C haplotype (OS: HR, 3.866;
P < 0.001).
Conclusions: VEGF gene polymorphisms were found to be an independent prognostic marker for patients with colorectal cancer. Accordingly, the
analysis of VEGF gene polymorphisms can help identify patient subgroups at high risk of a poor disease outcome.</description><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Chromatography, High Pressure Liquid</subject><subject>colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>gene</subject><subject>Genotype</subject><subject>Haplotypes</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymerase Chain Reaction</subject><subject>polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prognosis</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Survival Analysis</subject><subject>Tumors</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>VEGF</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAURi0EoqXwCKBsYJfi65_YWVZROyBVYoSAreXYTmOUxINvRqO-PR5moEtWtuTzXV99h5C3QK8BpP4IVOmaCs6uu-5rTVUNkqtn5BKkVDVnjXxe7n-ZC_IK8SelIICKl-QCNCjGJL8k-MOi2082V7eLT-sYpminapPTYR2rO-vWlKtNWEK1TdPjnPJujDhjdYOYXLRr8NUhFnKb08OSMGI1lMDWrjEsK57eujSlHNxa5nZ2cSG_Ji8GO2F4cz6vyPe722_dp_r-y-Zzd3NfOyGatWZcSe-ll0x71wtQQbWOOQhcN8w62Srt-76RXPSeAWWN5hoY5VYPmgql-BX5cJq7y-nXPuBq5oguTJNdQtqjURSUAtb-F2S0ZUy0uoDyBLqcEHMYzC7H2eZHA9QctZhj5eZYuSlaDFXmqKXk3p0_2Pdz8E-ps4cCvD8DRYedhlyKiviPY8Vc8cqfNh3jw3iIORj3p9IcMNjsRgPCgGkY_w0pUqOY</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Kim, Jong Gwang</creator><creator>Chae, Yee Soo</creator><creator>Sohn, Sang Kyun</creator><creator>Cho, Yoon Young</creator><creator>Moon, Joon Ho</creator><creator>Park, Jae Yong</creator><creator>Jeon, Seoung Woo</creator><creator>Lee, In Taek</creator><creator>Choi, Gyu Seog</creator><creator>Jun, Soo-Han</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>Vascular Endothelial Growth Factor Gene Polymorphisms Associated with Prognosis for Patients with Colorectal Cancer</title><author>Kim, Jong Gwang ; Chae, Yee Soo ; Sohn, Sang Kyun ; Cho, Yoon Young ; Moon, Joon Ho ; Park, Jae Yong ; Jeon, Seoung Woo ; Lee, In Taek ; Choi, Gyu Seog ; Jun, Soo-Han</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-2375dd5d528dcb417e79c2c1e3862ac5978dbb6534bd210268381203a8f804773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Chromatography, High Pressure Liquid</topic><topic>colorectal cancer</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>gene</topic><topic>Genotype</topic><topic>Haplotypes</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymerase Chain Reaction</topic><topic>polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prognosis</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Survival Analysis</topic><topic>Tumors</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jong Gwang</creatorcontrib><creatorcontrib>Chae, Yee Soo</creatorcontrib><creatorcontrib>Sohn, Sang Kyun</creatorcontrib><creatorcontrib>Cho, Yoon Young</creatorcontrib><creatorcontrib>Moon, Joon Ho</creatorcontrib><creatorcontrib>Park, Jae Yong</creatorcontrib><creatorcontrib>Jeon, Seoung Woo</creatorcontrib><creatorcontrib>Lee, In Taek</creatorcontrib><creatorcontrib>Choi, Gyu Seog</creatorcontrib><creatorcontrib>Jun, Soo-Han</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jong Gwang</au><au>Chae, Yee Soo</au><au>Sohn, Sang Kyun</au><au>Cho, Yoon Young</au><au>Moon, Joon Ho</au><au>Park, Jae Yong</au><au>Jeon, Seoung Woo</au><au>Lee, In Taek</au><au>Choi, Gyu Seog</au><au>Jun, Soo-Han</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vascular Endothelial Growth Factor Gene Polymorphisms Associated with Prognosis for Patients with Colorectal Cancer</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>14</volume><issue>1</issue><spage>62</spage><epage>66</epage><pages>62-66</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Purpose: Vascular endothelial growth factor (VEGF) or its family may be considered to play an important role in lymphangiogenesis
and lymphatic tumor spread, thereby affecting prognosis of colorectal cancer. Accordingly, the present study analyzed VEGF gene polymorphisms and their effect on the prognosis for patients with colorectal cancer.
Experimental Design: Four hundred and forty-five consecutive patients with surgically treated colorectal adenocarcinoma were enrolled in the present
study. The genomic DNA was extracted from fresh colorectal tissue and three VEGF (−2578C>A, −634G>C, and +936C>T) gene polymorphisms were determined using a PCR/denaturing high-performance liquid chromatography
assay.
Results: Multivariate survival analysis showed that the survival for the patients with the −634 G/C genotype [overall survival (OS):
hazard ratio (HR), 0.158; P < 0.001] or C/C genotype (OS: HR, 0.188; P < 0.001) were better than for the patients with the −634G/G genotype, whereas the +936 C/T genotype (OS: HR, 12.809; P < 0.001) or T/T genotype (OS: HR, 37.260; P < 0.001) was associated with a worse survival compared with the +936 C/C genotype. In haplotype analysis, the −2578A/−634G/+936T
haplotype exhibited a significantly worse survival when compared with the wild −2578C/−634G/+936C haplotype (OS: HR, 3.866;
P < 0.001).
Conclusions: VEGF gene polymorphisms were found to be an independent prognostic marker for patients with colorectal cancer. Accordingly, the
analysis of VEGF gene polymorphisms can help identify patient subgroups at high risk of a poor disease outcome.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>18172253</pmid><doi>10.1158/1078-0432.CCR-07-1537</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - genetics Adenocarcinoma - mortality Adenocarcinoma - pathology Adult Aged Aged, 80 and over Antineoplastic agents Biological and medical sciences Biomarkers, Tumor - genetics Chromatography, High Pressure Liquid colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Female Gastroenterology. Liver. Pancreas. Abdomen gene Genotype Haplotypes Humans Kaplan-Meier Estimate Male Medical sciences Middle Aged Pharmacology. Drug treatments Polymerase Chain Reaction polymorphism Polymorphism, Single Nucleotide Prognosis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Tumors Vascular Endothelial Growth Factor A - genetics VEGF |
| title | Vascular Endothelial Growth Factor Gene Polymorphisms Associated with Prognosis for Patients with Colorectal Cancer |
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