Analysis for the major contributor of collagenase to the primary cleavage of type II collagens in cartilage degradation

Abstract Degradation of type II collagen is a central process in cartilage destruction seen in osteoarthritis and rheumatoid arthritis. Primary cleavage of type II collagen at the collagenase site is rate-limiting and is, therefore, a critical step for its degradation. The major contributor to this...

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Veröffentlicht in:	Modern rheumatology 2005-06, Vol.15 (3), p.180-186
Hauptverfasser:	Yoshida, Mamoru, Tsuji, Michiko, Funasaki, Hiroki, Kan, Iwao, Fujii, Katsuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Cartilage degradation Collagenase RNA interference Type II collagen
Online-Zugang:	Volltext
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