Shear stress-induced activation of the AMP-activated protein kinase regulates FoxO1a and angiopoietin-2 in endothelial cells

Aims Phosphorylation of forkhead box O (FoxO) transcription factors induces their nuclear exclusion and proteosomal degradation. Here, we investigated the effect of fluid shear stress on FoxO1a in primary cultures of human endothelial cells and the kinases that regulate its phosphorylation. Methods...

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Veröffentlicht in:	Cardiovascular research 2008-01, Vol.77 (1), p.160-168
Hauptverfasser:	Dixit, Madhulika, Bess, Elke, Fisslthaler, Beate, Härtel, Frauke V., Noll, Thomas, Busse, Rudi, Fleming, Ingrid
Format:	Artikel
Sprache:	eng
Schlagworte:	AMP-Activated Protein Kinases Angiopoietin-2 - analysis Angiopoietin-2 - physiology Biological and medical sciences Cardiology. Vascular system Cells, Cultured Endothelial Cells - chemistry Endothelial Cells - metabolism Endothelial function Energy metabolism Forkhead Box Protein O1 Forkhead Transcription Factors - metabolism Humans Mechanotransduction Medical sciences Multienzyme Complexes - physiology Phosphorylation Protein kinases Protein-Serine-Threonine Kinases - physiology Proto-Oncogene Proteins c-akt - metabolism Stress, Mechanical Tumor Necrosis Factor-alpha - pharmacology
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