Expression of VLDLR in the Retina and Evolution of Subretinal Neovascularization in the Knockout Mouse Model's Retinal Angiomatous Proliferation

Very-low-density lipoprotein receptor (VLDLR) in knockout mice (vldlr(-/-)) has been reported to induce subretinal neovascularization. Therefore, VLDLR expression in the wild-type mouse retina was investigated and the retinal angiogenic process in vldlr(-/-) mice was characterized. VLDLR expression...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2008-01, Vol.49 (1), p.407-415
Hauptverfasser:	Hu, Wenzheng, Jiang, Aihua, Liang, Jing, Meng, Hongdi, Chang, Bo, Gao, Hua, Qiao, Xiaoxi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Disease Models, Animal Elastin - metabolism Endothelium, Vascular - metabolism Eye and associated structures. Visual pathways and centers. Vision Female Fluorescein Angiography Fluorescent Antibody Technique, Indirect Fundamental and applied biological sciences. Psychology Gene Expression - physiology Gene Silencing - physiology Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Confocal Ophthalmology Pigment Epithelium of Eye - metabolism Receptors, LDL - biosynthesis Receptors, LDL - genetics Retina - metabolism Retinal Neovascularization - genetics Retinal Neovascularization - metabolism Retinal Neovascularization - pathology Retinal Vessels - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Vertebrates: nervous system and sense organs
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