A comparison of albumin-bolus therapy versus normal saline-bolus therapy for hypotension in neonates
Objective: We compared responses to bolus infusion of 5% albumin (ALB) or normal saline (NS) for hypotension in neonates. Study Design: Hypotensive infants were given 10 ml kg −1 of NS or ALB. A second bolus was given for persistent hypotension. Dopamine therapy was started for hypotension after the...
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| Veröffentlicht in: | Journal of perinatology 2008-01, Vol.28 (1), p.29-33 |
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| creator | Lynch, S K Mullett, M D Graeber, J E Polak, M J |
| description | Objective:
We compared responses to bolus infusion of 5% albumin (ALB) or normal saline (NS) for hypotension in neonates.
Study Design:
Hypotensive infants were given 10 ml kg
−1
of NS or ALB. A second bolus was given for persistent hypotension. Dopamine therapy was started for hypotension after the second bolus. The primary response was increase in arterial blood pressure toward normal range 1 h postinfusion. Secondary measures included duration of normotension, meeting criteria for second bolus, meeting criteria for vasopressor support and cost comparison.
Result:
Those receiving ALB (
N
=49 ALB and 52 NS) were more likely to achieve a normotensive state (ALB=57.1%, NS=32.1%
P
=0.01) 1 h following the initial bolus therapy. Subsequently, the NS group was also more likely to qualify for vasopressor infusion (ALB=24.5%, NS=44.2%
P
=0.02). Overall cost for either therapy was equivalent.
Conclusion:
In hypotensive neonates, ALB results in a greater likelihood of achieving normotension and decreased subsequent use of vasopressors when compared to NS. |
| doi_str_mv | 10.1038/sj.jp.7211846 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_70174908</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A186689362</galeid><sourcerecordid>A186689362</sourcerecordid><originalsourceid>FETCH-LOGICAL-c416t-f5acca5ff610e958269715f0b3fcb7ab0fbd7d378ca4f1536a9de8db3c9e5faa3</originalsourceid><addsrcrecordid>eNpt0U1r3DAQBmBRGppt2mOvxbTQm7eSZUvycQn9gkAvyVmMZSlrI0uuxi7sv482u7A09CTEPLwazRDygdEto1x9xXE7zltZMaZq8YpsWC1F2TQ1f002VNa8VLwW1-Qt4kjpsSjfkGsmW9WKVm1IvytMnGZIA8ZQRFeA79ZpCGUX_YrFsrcJ5kPx1ybM1xDTBL5A8EOwL4iLqdgf5rjYgEPOGkIRbAywWHxHrhx4tO_P5w15-P7t_vZneff7x6_b3V1paiaW0jVgDDTOCUZt26hKtJI1jnbcmU5CR13Xy55LZaB2rOEC2t6qvuOmtY0D4Dfkyyl3TvHPanHR04DGeg-5kxW1pEzWLVUZfnoBx7imkHvTVZWnWinaZPT5hB7BWz0EF5cE5piod0wJoVouqsubz2pvwS97zINZ8gzwX1ieoEkRMVmn5zRMkA6aUX1cpcZRj7M-rzL7j-ce126y_UWfd5fB9gQwl8KjTZdP_D_xCYoQqqs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220382805</pqid></control><display><type>article</type><title>A comparison of albumin-bolus therapy versus normal saline-bolus therapy for hypotension in neonates</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Lynch, S K ; Mullett, M D ; Graeber, J E ; Polak, M J</creator><creatorcontrib>Lynch, S K ; Mullett, M D ; Graeber, J E ; Polak, M J</creatorcontrib><description>Objective:
We compared responses to bolus infusion of 5% albumin (ALB) or normal saline (NS) for hypotension in neonates.
Study Design:
Hypotensive infants were given 10 ml kg
−1
of NS or ALB. A second bolus was given for persistent hypotension. Dopamine therapy was started for hypotension after the second bolus. The primary response was increase in arterial blood pressure toward normal range 1 h postinfusion. Secondary measures included duration of normotension, meeting criteria for second bolus, meeting criteria for vasopressor support and cost comparison.
Result:
Those receiving ALB (
N
=49 ALB and 52 NS) were more likely to achieve a normotensive state (ALB=57.1%, NS=32.1%
P
=0.01) 1 h following the initial bolus therapy. Subsequently, the NS group was also more likely to qualify for vasopressor infusion (ALB=24.5%, NS=44.2%
P
=0.02). Overall cost for either therapy was equivalent.
Conclusion:
In hypotensive neonates, ALB results in a greater likelihood of achieving normotension and decreased subsequent use of vasopressors when compared to NS.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/sj.jp.7211846</identifier><identifier>PMID: 17989698</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Albumins - administration & dosage ; Blood Pressure - drug effects ; Comparative analysis ; Diagnosis ; Dopamine ; Dosage and administration ; Drug therapy ; Female ; Gestational Age ; Health aspects ; Humans ; Hypotension ; Hypotension - drug therapy ; Infant, Newborn ; Infants (Newborn) ; Infusions, Intravenous - methods ; Intensive Care Units, Neonatal ; Male ; Medicine ; Medicine & Public Health ; original-article ; Pediatric Surgery ; Pediatrics ; Risk factors ; Sodium Chloride - administration & dosage ; Treatment Outcome</subject><ispartof>Journal of perinatology, 2008-01, Vol.28 (1), p.29-33</ispartof><rights>Springer Nature America, Inc. 2008</rights><rights>COPYRIGHT 2008 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-f5acca5ff610e958269715f0b3fcb7ab0fbd7d378ca4f1536a9de8db3c9e5faa3</citedby><cites>FETCH-LOGICAL-c416t-f5acca5ff610e958269715f0b3fcb7ab0fbd7d378ca4f1536a9de8db3c9e5faa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.jp.7211846$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.jp.7211846$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17989698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lynch, S K</creatorcontrib><creatorcontrib>Mullett, M D</creatorcontrib><creatorcontrib>Graeber, J E</creatorcontrib><creatorcontrib>Polak, M J</creatorcontrib><title>A comparison of albumin-bolus therapy versus normal saline-bolus therapy for hypotension in neonates</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective:
We compared responses to bolus infusion of 5% albumin (ALB) or normal saline (NS) for hypotension in neonates.
Study Design:
Hypotensive infants were given 10 ml kg
−1
of NS or ALB. A second bolus was given for persistent hypotension. Dopamine therapy was started for hypotension after the second bolus. The primary response was increase in arterial blood pressure toward normal range 1 h postinfusion. Secondary measures included duration of normotension, meeting criteria for second bolus, meeting criteria for vasopressor support and cost comparison.
Result:
Those receiving ALB (
N
=49 ALB and 52 NS) were more likely to achieve a normotensive state (ALB=57.1%, NS=32.1%
P
=0.01) 1 h following the initial bolus therapy. Subsequently, the NS group was also more likely to qualify for vasopressor infusion (ALB=24.5%, NS=44.2%
P
=0.02). Overall cost for either therapy was equivalent.
Conclusion:
In hypotensive neonates, ALB results in a greater likelihood of achieving normotension and decreased subsequent use of vasopressors when compared to NS.</description><subject>Albumins - administration & dosage</subject><subject>Blood Pressure - drug effects</subject><subject>Comparative analysis</subject><subject>Diagnosis</subject><subject>Dopamine</subject><subject>Dosage and administration</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypotension</subject><subject>Hypotension - drug therapy</subject><subject>Infant, Newborn</subject><subject>Infants (Newborn)</subject><subject>Infusions, Intravenous - methods</subject><subject>Intensive Care Units, Neonatal</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>original-article</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Risk factors</subject><subject>Sodium Chloride - administration & dosage</subject><subject>Treatment Outcome</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpt0U1r3DAQBmBRGppt2mOvxbTQm7eSZUvycQn9gkAvyVmMZSlrI0uuxi7sv482u7A09CTEPLwazRDygdEto1x9xXE7zltZMaZq8YpsWC1F2TQ1f002VNa8VLwW1-Qt4kjpsSjfkGsmW9WKVm1IvytMnGZIA8ZQRFeA79ZpCGUX_YrFsrcJ5kPx1ybM1xDTBL5A8EOwL4iLqdgf5rjYgEPOGkIRbAywWHxHrhx4tO_P5w15-P7t_vZneff7x6_b3V1paiaW0jVgDDTOCUZt26hKtJI1jnbcmU5CR13Xy55LZaB2rOEC2t6qvuOmtY0D4Dfkyyl3TvHPanHR04DGeg-5kxW1pEzWLVUZfnoBx7imkHvTVZWnWinaZPT5hB7BWz0EF5cE5piod0wJoVouqsubz2pvwS97zINZ8gzwX1ieoEkRMVmn5zRMkA6aUX1cpcZRj7M-rzL7j-ce126y_UWfd5fB9gQwl8KjTZdP_D_xCYoQqqs</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Lynch, S K</creator><creator>Mullett, M D</creator><creator>Graeber, J E</creator><creator>Polak, M J</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080101</creationdate><title>A comparison of albumin-bolus therapy versus normal saline-bolus therapy for hypotension in neonates</title><author>Lynch, S K ; Mullett, M D ; Graeber, J E ; Polak, M J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-f5acca5ff610e958269715f0b3fcb7ab0fbd7d378ca4f1536a9de8db3c9e5faa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Albumins - administration & dosage</topic><topic>Blood Pressure - drug effects</topic><topic>Comparative analysis</topic><topic>Diagnosis</topic><topic>Dopamine</topic><topic>Dosage and administration</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Hypotension</topic><topic>Hypotension - drug therapy</topic><topic>Infant, Newborn</topic><topic>Infants (Newborn)</topic><topic>Infusions, Intravenous - methods</topic><topic>Intensive Care Units, Neonatal</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>original-article</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Risk factors</topic><topic>Sodium Chloride - administration & dosage</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lynch, S K</creatorcontrib><creatorcontrib>Mullett, M D</creatorcontrib><creatorcontrib>Graeber, J E</creatorcontrib><creatorcontrib>Polak, M J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lynch, S K</au><au>Mullett, M D</au><au>Graeber, J E</au><au>Polak, M J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comparison of albumin-bolus therapy versus normal saline-bolus therapy for hypotension in neonates</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>28</volume><issue>1</issue><spage>29</spage><epage>33</epage><pages>29-33</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective:
We compared responses to bolus infusion of 5% albumin (ALB) or normal saline (NS) for hypotension in neonates.
Study Design:
Hypotensive infants were given 10 ml kg
−1
of NS or ALB. A second bolus was given for persistent hypotension. Dopamine therapy was started for hypotension after the second bolus. The primary response was increase in arterial blood pressure toward normal range 1 h postinfusion. Secondary measures included duration of normotension, meeting criteria for second bolus, meeting criteria for vasopressor support and cost comparison.
Result:
Those receiving ALB (
N
=49 ALB and 52 NS) were more likely to achieve a normotensive state (ALB=57.1%, NS=32.1%
P
=0.01) 1 h following the initial bolus therapy. Subsequently, the NS group was also more likely to qualify for vasopressor infusion (ALB=24.5%, NS=44.2%
P
=0.02). Overall cost for either therapy was equivalent.
Conclusion:
In hypotensive neonates, ALB results in a greater likelihood of achieving normotension and decreased subsequent use of vasopressors when compared to NS.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>17989698</pmid><doi>10.1038/sj.jp.7211846</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-8346 |
| ispartof | Journal of perinatology, 2008-01, Vol.28 (1), p.29-33 |
| issn | 0743-8346 1476-5543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70174908 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Albumins - administration & dosage Blood Pressure - drug effects Comparative analysis Diagnosis Dopamine Dosage and administration Drug therapy Female Gestational Age Health aspects Humans Hypotension Hypotension - drug therapy Infant, Newborn Infants (Newborn) Infusions, Intravenous - methods Intensive Care Units, Neonatal Male Medicine Medicine & Public Health original-article Pediatric Surgery Pediatrics Risk factors Sodium Chloride - administration & dosage Treatment Outcome |
| title | A comparison of albumin-bolus therapy versus normal saline-bolus therapy for hypotension in neonates |
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