Iron Regulates L-Cystine Uptake and Glutathione Levels in Lens Epithelial and Retinal Pigment Epithelial Cells by Its Effect on Cytosolic Aconitase

The authors previously published the novel finding that iron regulates L-glutamate synthesis and accumulation in the cell-conditioned medium (CCM) by increasing cytosolic aconitase activity in cultured lens epithelial cells (LECs), retinal pigment epithelial (RPE) cells, and neurons. The present stu...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2008-01, Vol.49 (1), p.310-319
Hauptverfasser:	Lall, Marilyn M, Ferrell, Jenny, Nagar, Steve, Fleisher, Lloyd N, McGahan, M. Christine
Format:	Artikel
Sprache:	eng
Schlagworte:	2,2'-Dipyridyl - pharmacology Aconitate Hydratase - antagonists & inhibitors Aconitate Hydratase - metabolism Amino Acid Transport System y+ - genetics Amino Acid Transport System y+ - metabolism Animals Biological and medical sciences Cells, Cultured Chelating Agents - pharmacology Cystine - metabolism Cytosol Dogs Enzyme Inhibitors - pharmacology Epithelial Cells - drug effects Epithelial Cells - metabolism Eye and associated structures. Visual pathways and centers. Vision Fluorescent Antibody Technique, Indirect Fundamental and applied biological sciences. Psychology Gene Expression Glutathione - metabolism Immunoblotting Lens, Crystalline - drug effects Lens, Crystalline - metabolism Medical sciences Ophthalmology Oxalates - pharmacology Pigment Epithelium of Eye - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Transferrin - pharmacology Vertebrates: nervous system and sense organs
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