Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants
Objective The purpose of this study was to investigate maternal plasma concentrations of asymmetric dimethylarginine (ADMA) in mid pregnancy and at the time of disease in women who experience preeclampsia, compared with women with uncomplicated pregnancies and women with small-for-gestational-age in...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 2008, Vol.198 (1), p.112.e1-112.e7 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Speer, Paul D., MD Powers, Robert W., PhD Frank, Michael P., BS Harger, Gail, MS Markovic, Nina, PhD Roberts, James M., MD |
| description | Objective The purpose of this study was to investigate maternal plasma concentrations of asymmetric dimethylarginine (ADMA) in mid pregnancy and at the time of disease in women who experience preeclampsia, compared with women with uncomplicated pregnancies and women with small-for-gestational-age infants. Study Design Plasma samples were collected at mid-pregnancy and at the time of delivery from 31 women with uncomplicated pregnancies, from 12 women with small-for-gestational-age infants, and from 15 women with preeclampsia. ADMA and L-arginine concentrations were measured using high-pressure liquid chromatography. Results Maternal ADMA concentrations were elevated at mid pregnancy and remained elevated at delivery in women who later experienced preeclampsia (0.45 ± 0.09 μmol/L) compared with women with uncomplicated pregnancies (0.34 ± 0.08 μmol/L; P < .01) and with women with small-for-gestational-age infants (0.33 ± 0.06 μmol/L; P < .01). Conclusion Maternal ADMA concentrations are higher in mid pregnancy in women who experience preeclampsia, compared with women with uncomplicated pregnancies and small-for-gestational-age infants. Elevated ADMA concentration before clinical onset of preeclampsia suggests a role of this nitric oxide synthase inhibitor in the pathophysiologic condition of preeclampsia. |
| doi_str_mv | 10.1016/j.ajog.2007.05.052 |
| format | Article |
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Study Design Plasma samples were collected at mid-pregnancy and at the time of delivery from 31 women with uncomplicated pregnancies, from 12 women with small-for-gestational-age infants, and from 15 women with preeclampsia. ADMA and L-arginine concentrations were measured using high-pressure liquid chromatography. Results Maternal ADMA concentrations were elevated at mid pregnancy and remained elevated at delivery in women who later experienced preeclampsia (0.45 ± 0.09 μmol/L) compared with women with uncomplicated pregnancies (0.34 ± 0.08 μmol/L; P < .01) and with women with small-for-gestational-age infants (0.33 ± 0.06 μmol/L; P < .01). Conclusion Maternal ADMA concentrations are higher in mid pregnancy in women who experience preeclampsia, compared with women with uncomplicated pregnancies and small-for-gestational-age infants. Elevated ADMA concentration before clinical onset of preeclampsia suggests a role of this nitric oxide synthase inhibitor in the pathophysiologic condition of preeclampsia.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2007.05.052</identifier><identifier>PMID: 18166322</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Adult ; arginine ; Arginine - analogs & derivatives ; Arginine - blood ; asymmetric dimethylarginine ; Biological and medical sciences ; Biomarkers - blood ; Case-Control Studies ; Diseases of mother, fetus and pregnancy ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; Infant, Small for Gestational Age - blood ; Medical sciences ; Obstetrics and Gynecology ; Pre-Eclampsia - blood ; Predictive Value of Tests ; preeclampsia ; Pregnancy ; Pregnancy Outcome ; Pregnancy. Fetus. Placenta ; Probability ; Reference Values ; Risk Assessment ; Sampling Studies ; Sensitivity and Specificity ; small-for-gestational-age</subject><ispartof>American journal of obstetrics and gynecology, 2008, Vol.198 (1), p.112.e1-112.e7</ispartof><rights>Mosby, Inc.</rights><rights>2008 Mosby, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-189ef7f9c49e11062b7acf55de390389218e04c32b0188f2439c324af79c19c13</citedby><cites>FETCH-LOGICAL-c483t-189ef7f9c49e11062b7acf55de390389218e04c32b0188f2439c324af79c19c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002937807007211$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,4010,4036,4037,23909,23910,25118,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20049639$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18166322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Speer, Paul D., MD</creatorcontrib><creatorcontrib>Powers, Robert W., PhD</creatorcontrib><creatorcontrib>Frank, Michael P., BS</creatorcontrib><creatorcontrib>Harger, Gail, MS</creatorcontrib><creatorcontrib>Markovic, Nina, PhD</creatorcontrib><creatorcontrib>Roberts, James M., MD</creatorcontrib><title>Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective The purpose of this study was to investigate maternal plasma concentrations of asymmetric dimethylarginine (ADMA) in mid pregnancy and at the time of disease in women who experience preeclampsia, compared with women with uncomplicated pregnancies and women with small-for-gestational-age infants. Study Design Plasma samples were collected at mid-pregnancy and at the time of delivery from 31 women with uncomplicated pregnancies, from 12 women with small-for-gestational-age infants, and from 15 women with preeclampsia. ADMA and L-arginine concentrations were measured using high-pressure liquid chromatography. Results Maternal ADMA concentrations were elevated at mid pregnancy and remained elevated at delivery in women who later experienced preeclampsia (0.45 ± 0.09 μmol/L) compared with women with uncomplicated pregnancies (0.34 ± 0.08 μmol/L; P < .01) and with women with small-for-gestational-age infants (0.33 ± 0.06 μmol/L; P < .01). Conclusion Maternal ADMA concentrations are higher in mid pregnancy in women who experience preeclampsia, compared with women with uncomplicated pregnancies and small-for-gestational-age infants. Elevated ADMA concentration before clinical onset of preeclampsia suggests a role of this nitric oxide synthase inhibitor in the pathophysiologic condition of preeclampsia.</description><subject>Adult</subject><subject>arginine</subject><subject>Arginine - analogs & derivatives</subject><subject>Arginine - blood</subject><subject>asymmetric dimethylarginine</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Small for Gestational Age - blood</subject><subject>Medical sciences</subject><subject>Obstetrics and Gynecology</subject><subject>Pre-Eclampsia - blood</subject><subject>Predictive Value of Tests</subject><subject>preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Probability</subject><subject>Reference Values</subject><subject>Risk Assessment</subject><subject>Sampling Studies</subject><subject>Sensitivity and Specificity</subject><subject>small-for-gestational-age</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UtuKFDEQDaK4s6s_4IP0iz5tj7n0JQFZkGW9wIIP6nPIpCu9adPJmKRX5iP8Z9POqOCDUFCpyqlDcU4h9IzgLcGkezVt1RTGLcW43-K2BH2ANgSLvu54xx-iDcaY1oL1_AydpzStJRX0MTojnHQdo3SDftw4uFcZhkqlwzxDjlZXgy2Pu4NTcbTeeqh08Bp8jirb4FO1j6BhKG1XvrVyawO0U_M-WXVZ7ZZc-ZDX7uiV1xZS9d3muyrNyrnahFiPkPIvMuVqNUJlvVE-pyfokVEuwdNTvkBf3t58vn5f33589-H6zW2tG85yTbgA0xuhGwGE4I7ueqVN2w7ABGZcUMIBN5rRHSacG9owUYpGmV5oUoJdoJdH3n0M35ayi5xt0uCc8hCWJHtM-qZlTQHSI1DHkFIEI_fRzioeJMFyNUFOcjVBriZI3JagZej5iX3ZzTD8HTmpXgAvTgCVinwmriKlP7jC1YiOiYJ7fcRB0eLeQpSpiFmsGGxxIMsh2P_vcfXP-G_DvsIB0hSWWPRPkshEJZaf1vtYrwX3hYQSwn4CNgm9Vg</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Speer, Paul D., MD</creator><creator>Powers, Robert W., PhD</creator><creator>Frank, Michael P., BS</creator><creator>Harger, Gail, MS</creator><creator>Markovic, Nina, PhD</creator><creator>Roberts, James M., MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants</title><author>Speer, Paul D., MD ; Powers, Robert W., PhD ; Frank, Michael P., BS ; Harger, Gail, MS ; Markovic, Nina, PhD ; Roberts, James M., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-189ef7f9c49e11062b7acf55de390389218e04c32b0188f2439c324af79c19c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>arginine</topic><topic>Arginine - analogs & derivatives</topic><topic>Arginine - blood</topic><topic>asymmetric dimethylarginine</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Small for Gestational Age - blood</topic><topic>Medical sciences</topic><topic>Obstetrics and Gynecology</topic><topic>Pre-Eclampsia - blood</topic><topic>Predictive Value of Tests</topic><topic>preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Probability</topic><topic>Reference Values</topic><topic>Risk Assessment</topic><topic>Sampling Studies</topic><topic>Sensitivity and Specificity</topic><topic>small-for-gestational-age</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Speer, Paul D., MD</creatorcontrib><creatorcontrib>Powers, Robert W., PhD</creatorcontrib><creatorcontrib>Frank, Michael P., BS</creatorcontrib><creatorcontrib>Harger, Gail, MS</creatorcontrib><creatorcontrib>Markovic, Nina, PhD</creatorcontrib><creatorcontrib>Roberts, James M., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Speer, Paul D., MD</au><au>Powers, Robert W., PhD</au><au>Frank, Michael P., BS</au><au>Harger, Gail, MS</au><au>Markovic, Nina, PhD</au><au>Roberts, James M., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2008</date><risdate>2008</risdate><volume>198</volume><issue>1</issue><spage>112.e1</spage><epage>112.e7</epage><pages>112.e1-112.e7</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective The purpose of this study was to investigate maternal plasma concentrations of asymmetric dimethylarginine (ADMA) in mid pregnancy and at the time of disease in women who experience preeclampsia, compared with women with uncomplicated pregnancies and women with small-for-gestational-age infants. Study Design Plasma samples were collected at mid-pregnancy and at the time of delivery from 31 women with uncomplicated pregnancies, from 12 women with small-for-gestational-age infants, and from 15 women with preeclampsia. ADMA and L-arginine concentrations were measured using high-pressure liquid chromatography. Results Maternal ADMA concentrations were elevated at mid pregnancy and remained elevated at delivery in women who later experienced preeclampsia (0.45 ± 0.09 μmol/L) compared with women with uncomplicated pregnancies (0.34 ± 0.08 μmol/L; P < .01) and with women with small-for-gestational-age infants (0.33 ± 0.06 μmol/L; P < .01). Conclusion Maternal ADMA concentrations are higher in mid pregnancy in women who experience preeclampsia, compared with women with uncomplicated pregnancies and small-for-gestational-age infants. Elevated ADMA concentration before clinical onset of preeclampsia suggests a role of this nitric oxide synthase inhibitor in the pathophysiologic condition of preeclampsia.</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>18166322</pmid><doi>10.1016/j.ajog.2007.05.052</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult arginine Arginine - analogs & derivatives Arginine - blood asymmetric dimethylarginine Biological and medical sciences Biomarkers - blood Case-Control Studies Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans Infant, Newborn Infant, Small for Gestational Age - blood Medical sciences Obstetrics and Gynecology Pre-Eclampsia - blood Predictive Value of Tests preeclampsia Pregnancy Pregnancy Outcome Pregnancy. Fetus. Placenta Probability Reference Values Risk Assessment Sampling Studies Sensitivity and Specificity small-for-gestational-age |
| title | Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants |
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