Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice

Puerarin is an isoflavone derived from Kudzu roots and has antioxidant and hypocholesterolemic effects; however, its insolubility often limits its biological availability in vivo. Using a novel transglycosylation process, the solubility of puerarin glycosides was increased > 100-fold, but it was...

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Veröffentlicht in:	European journal of pharmacology 2008-01, Vol.578 (2), p.159-170
Hauptverfasser:	Chung, Mi Ja, Sung, Nak-Ju, Park, Cheon-Seok, Kweon, Dong-Keon, Mantovani, Alberto, Moon, Tae-Wha, Lee, Sung-Joon, Park, Kwan-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - genetics Acyl Coenzyme A - metabolism Animals Anticholesteremic Agents - chemistry Anticholesteremic Agents - pharmacology Antioxidant Biological and medical sciences Cell Line, Tumor Cholesterol - blood Cholesterol - metabolism Cholesterol 7-alpha-Hydroxylase - genetics Cholesterol 7-alpha-Hydroxylase - metabolism Dose-Response Relationship, Drug Free Radical Scavengers - chemistry Free Radical Scavengers - pharmacology Free Radicals - chemistry Glycosides - chemistry Glycosides - pharmacology Glycosylation Hepatocytes - drug effects Hepatocytes - metabolism HMG-CoA reductase Humans Isoflavones - chemistry Isoflavones - pharmacology Liver - drug effects Liver - enzymology Liver - metabolism Low-density lipoprotein receptor Medical sciences Mice Mice, Inbred C57BL Pharmacology. Drug treatments Puerarin glycoside Receptors, LDL - genetics Receptors, LDL - metabolism RNA, Messenger - metabolism Solubility Solvents - chemistry Transcription, Genetic - drug effects Transfection Water - chemistry
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