Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni
Lemnalol (8-isopropyl-5-methyl-4-methylene-decahydro-1,5-cyclo-naphthalen-3-ol) is a natural compound isolated from the marine soft coral Lemnalia cervicorni. In the present study, the anti-inflammatory and anti-nociceptive properties of lemnalol were investigated in lipopolysaccharide (LPS)-stimula...
Gespeichert in:
| Veröffentlicht in: | European journal of pharmacology 2008-01, Vol.578 (2), p.323-331 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 331 |
|---|---|
| container_issue | 2 |
| container_start_page | 323 |
| container_title | European journal of pharmacology |
| container_volume | 578 |
| creator | Jean, Yen-Hsuan Chen, Wu-Fu Duh, Chang-Yi Huang, Shi-Ying Hsu, Chi-Hsin Lin, Chan-Shing Sung, Chun-Sung Chen, I-Ming Wen, Zhi-Hong |
| description | Lemnalol (8-isopropyl-5-methyl-4-methylene-decahydro-1,5-cyclo-naphthalen-3-ol) is a natural compound isolated from the marine soft coral
Lemnalia cervicorni. In the present study, the anti-inflammatory and anti-nociceptive properties of lemnalol were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and carrageenan-injected rats, respectively. Our results demonstrate that lemnalol significantly inhibited the expression of the pro-inflammatory proteins, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in LPS-stimulated RAW 264.7 cells. An
in vivo inflammation model was induced by intraplantar injection of carrageenan into rat hind paws. An intramuscular injection of lemnalol (15 mg/kg) 10 min before carrageenan injection resulted in significant inhibition of carrageenan-induced rat paw edema and thermal hyperalgesia behavior. Western blot experiments revealed that the carrageenan-induced expression of iNOS and COX-2 in paw tissue was significantly down-regulated by lemnalol. Moreover, post-intrathecal injection of lemnalol produced a dose-dependent anti-nociceptive effect in carrageenan-injected rats (1 and 5 μg). The present results indicate that the marine-derived compound lemnalol had anti-inflammatory and analgesic effects in LPS-stimulated RAW 264.7 cells and carrageenan-injected rats, respectively. In addition, inhibition of elevated iNOS and COX-2 protein expression as well as neurophil infiltration of carrageenan-injected paws may be involved in the beneficial effects of lemnalol. |
| doi_str_mv | 10.1016/j.ejphar.2007.08.048 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70173834</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014299907009855</els_id><sourcerecordid>70173834</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-dbf74bdc2d316509820ce2e722c186477858bbaa9c47d7462b2fb1ac78cd12183</originalsourceid><addsrcrecordid>eNp9kdGO1CAUhhujccfVNzCGG73rCExb6I2J2bi6ySTe6DU5hdMdJhQq0M327Xw0mZ2J3nlFcvJ9Pxz-qnrL6JZR1n08bvE4HyBuOaViS-WWNvJZtWFS9DUVjD-vNpSypuZ9319Vr1I6UkrbnrcvqysmetbtWrqpft95s2g7OCTe5mg1CY_WIEmrzwdISMAbolftQnhc79GXUc3JDDFbbWfISKwvTLa19aODaYIc4vpkgQd3j6lE4jiizomEkeRDuQjyEsGRCaL1SHSY5rAUweFUlODIGMNEbkOcQgJPUhhzgU7G_omwQDTGB1tm3r6uXozgEr65nNfVz9svP26-1fvvX-9uPu9r3bRdrs0wimYwmpsd61raS041chScaya7RgjZymEA6HUjjGg6PvBxYKCF1IZxJnfX1Ydz7hzDrwVTVpNNGp0Dj2FJSlAmdnLXFLA5gzqGlCKOao62rLoqRtWpOXVU5-bUqTlFpSrNFe3dJX8ZJjT_pEtVBXh_ASBpcGMEr236y5UsynjHCvfpzGH5jQeLUSVt0Ws0NpYWlAn2_y_5A7rOvmI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70173834</pqid></control><display><type>article</type><title>Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Jean, Yen-Hsuan ; Chen, Wu-Fu ; Duh, Chang-Yi ; Huang, Shi-Ying ; Hsu, Chi-Hsin ; Lin, Chan-Shing ; Sung, Chun-Sung ; Chen, I-Ming ; Wen, Zhi-Hong</creator><creatorcontrib>Jean, Yen-Hsuan ; Chen, Wu-Fu ; Duh, Chang-Yi ; Huang, Shi-Ying ; Hsu, Chi-Hsin ; Lin, Chan-Shing ; Sung, Chun-Sung ; Chen, I-Ming ; Wen, Zhi-Hong</creatorcontrib><description>Lemnalol (8-isopropyl-5-methyl-4-methylene-decahydro-1,5-cyclo-naphthalen-3-ol) is a natural compound isolated from the marine soft coral
Lemnalia cervicorni. In the present study, the anti-inflammatory and anti-nociceptive properties of lemnalol were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and carrageenan-injected rats, respectively. Our results demonstrate that lemnalol significantly inhibited the expression of the pro-inflammatory proteins, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in LPS-stimulated RAW 264.7 cells. An
in vivo inflammation model was induced by intraplantar injection of carrageenan into rat hind paws. An intramuscular injection of lemnalol (15 mg/kg) 10 min before carrageenan injection resulted in significant inhibition of carrageenan-induced rat paw edema and thermal hyperalgesia behavior. Western blot experiments revealed that the carrageenan-induced expression of iNOS and COX-2 in paw tissue was significantly down-regulated by lemnalol. Moreover, post-intrathecal injection of lemnalol produced a dose-dependent anti-nociceptive effect in carrageenan-injected rats (1 and 5 μg). The present results indicate that the marine-derived compound lemnalol had anti-inflammatory and analgesic effects in LPS-stimulated RAW 264.7 cells and carrageenan-injected rats, respectively. In addition, inhibition of elevated iNOS and COX-2 protein expression as well as neurophil infiltration of carrageenan-injected paws may be involved in the beneficial effects of lemnalol.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2007.08.048</identifier><identifier>PMID: 17916350</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject><![CDATA[Analgesia ; Analgesics - administration & dosage ; Analgesics - isolation & purification ; Analgesics - pharmacology ; Animals ; Anthozoa - chemistry ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - isolation & purification ; Anti-Inflammatory Agents - pharmacology ; Biological and medical sciences ; Carrageenan ; Cell Line ; COX-2 ; Cyclooxygenase 2 - metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Hot Temperature ; Hyperalgesia - etiology ; Hyperalgesia - pathology ; Hyperalgesia - physiopathology ; Hyperalgesia - prevention & control ; Immunohistochemistry ; Inflammation ; Inflammation - chemically induced ; Inflammation - complications ; Inflammation - pathology ; Inflammation - physiopathology ; Inflammation - prevention & control ; Injections, Spinal ; iNOS ; Intrathecal ; Lemnalol ; Lipopolysaccharides - pharmacology ; Macrophages - drug effects ; Macrophages - enzymology ; Male ; Medical sciences ; Mice ; Neutrophil Infiltration - drug effects ; Nitric Oxide Synthase Type II - metabolism ; Pain Measurement ; Pain Threshold - drug effects ; Pharmacology. Drug treatments ; Rats ; Rats, Wistar ; Sesquiterpenes - administration & dosage ; Sesquiterpenes - isolation & purification ; Sesquiterpenes - pharmacology ; Time Factors]]></subject><ispartof>European journal of pharmacology, 2008-01, Vol.578 (2), p.323-331</ispartof><rights>2007 Elsevier B.V.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-dbf74bdc2d316509820ce2e722c186477858bbaa9c47d7462b2fb1ac78cd12183</citedby><cites>FETCH-LOGICAL-c456t-dbf74bdc2d316509820ce2e722c186477858bbaa9c47d7462b2fb1ac78cd12183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejphar.2007.08.048$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20001261$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17916350$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jean, Yen-Hsuan</creatorcontrib><creatorcontrib>Chen, Wu-Fu</creatorcontrib><creatorcontrib>Duh, Chang-Yi</creatorcontrib><creatorcontrib>Huang, Shi-Ying</creatorcontrib><creatorcontrib>Hsu, Chi-Hsin</creatorcontrib><creatorcontrib>Lin, Chan-Shing</creatorcontrib><creatorcontrib>Sung, Chun-Sung</creatorcontrib><creatorcontrib>Chen, I-Ming</creatorcontrib><creatorcontrib>Wen, Zhi-Hong</creatorcontrib><title>Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Lemnalol (8-isopropyl-5-methyl-4-methylene-decahydro-1,5-cyclo-naphthalen-3-ol) is a natural compound isolated from the marine soft coral
Lemnalia cervicorni. In the present study, the anti-inflammatory and anti-nociceptive properties of lemnalol were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and carrageenan-injected rats, respectively. Our results demonstrate that lemnalol significantly inhibited the expression of the pro-inflammatory proteins, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in LPS-stimulated RAW 264.7 cells. An
in vivo inflammation model was induced by intraplantar injection of carrageenan into rat hind paws. An intramuscular injection of lemnalol (15 mg/kg) 10 min before carrageenan injection resulted in significant inhibition of carrageenan-induced rat paw edema and thermal hyperalgesia behavior. Western blot experiments revealed that the carrageenan-induced expression of iNOS and COX-2 in paw tissue was significantly down-regulated by lemnalol. Moreover, post-intrathecal injection of lemnalol produced a dose-dependent anti-nociceptive effect in carrageenan-injected rats (1 and 5 μg). The present results indicate that the marine-derived compound lemnalol had anti-inflammatory and analgesic effects in LPS-stimulated RAW 264.7 cells and carrageenan-injected rats, respectively. In addition, inhibition of elevated iNOS and COX-2 protein expression as well as neurophil infiltration of carrageenan-injected paws may be involved in the beneficial effects of lemnalol.</description><subject>Analgesia</subject><subject>Analgesics - administration & dosage</subject><subject>Analgesics - isolation & purification</subject><subject>Analgesics - pharmacology</subject><subject>Animals</subject><subject>Anthozoa - chemistry</subject><subject>Anti-Inflammatory Agents - administration & dosage</subject><subject>Anti-Inflammatory Agents - isolation & purification</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Carrageenan</subject><subject>Cell Line</subject><subject>COX-2</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Hot Temperature</subject><subject>Hyperalgesia - etiology</subject><subject>Hyperalgesia - pathology</subject><subject>Hyperalgesia - physiopathology</subject><subject>Hyperalgesia - prevention & control</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - complications</subject><subject>Inflammation - pathology</subject><subject>Inflammation - physiopathology</subject><subject>Inflammation - prevention & control</subject><subject>Injections, Spinal</subject><subject>iNOS</subject><subject>Intrathecal</subject><subject>Lemnalol</subject><subject>Lipopolysaccharides - pharmacology</subject><subject>Macrophages - drug effects</subject><subject>Macrophages - enzymology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Neutrophil Infiltration - drug effects</subject><subject>Nitric Oxide Synthase Type II - metabolism</subject><subject>Pain Measurement</subject><subject>Pain Threshold - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sesquiterpenes - administration & dosage</subject><subject>Sesquiterpenes - isolation & purification</subject><subject>Sesquiterpenes - pharmacology</subject><subject>Time Factors</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kdGO1CAUhhujccfVNzCGG73rCExb6I2J2bi6ySTe6DU5hdMdJhQq0M327Xw0mZ2J3nlFcvJ9Pxz-qnrL6JZR1n08bvE4HyBuOaViS-WWNvJZtWFS9DUVjD-vNpSypuZ9319Vr1I6UkrbnrcvqysmetbtWrqpft95s2g7OCTe5mg1CY_WIEmrzwdISMAbolftQnhc79GXUc3JDDFbbWfISKwvTLa19aODaYIc4vpkgQd3j6lE4jiizomEkeRDuQjyEsGRCaL1SHSY5rAUweFUlODIGMNEbkOcQgJPUhhzgU7G_omwQDTGB1tm3r6uXozgEr65nNfVz9svP26-1fvvX-9uPu9r3bRdrs0wimYwmpsd61raS041chScaya7RgjZymEA6HUjjGg6PvBxYKCF1IZxJnfX1Ydz7hzDrwVTVpNNGp0Dj2FJSlAmdnLXFLA5gzqGlCKOao62rLoqRtWpOXVU5-bUqTlFpSrNFe3dJX8ZJjT_pEtVBXh_ASBpcGMEr236y5UsynjHCvfpzGH5jQeLUSVt0Ws0NpYWlAn2_y_5A7rOvmI</recordid><startdate>20080114</startdate><enddate>20080114</enddate><creator>Jean, Yen-Hsuan</creator><creator>Chen, Wu-Fu</creator><creator>Duh, Chang-Yi</creator><creator>Huang, Shi-Ying</creator><creator>Hsu, Chi-Hsin</creator><creator>Lin, Chan-Shing</creator><creator>Sung, Chun-Sung</creator><creator>Chen, I-Ming</creator><creator>Wen, Zhi-Hong</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080114</creationdate><title>Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni</title><author>Jean, Yen-Hsuan ; Chen, Wu-Fu ; Duh, Chang-Yi ; Huang, Shi-Ying ; Hsu, Chi-Hsin ; Lin, Chan-Shing ; Sung, Chun-Sung ; Chen, I-Ming ; Wen, Zhi-Hong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-dbf74bdc2d316509820ce2e722c186477858bbaa9c47d7462b2fb1ac78cd12183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Analgesia</topic><topic>Analgesics - administration & dosage</topic><topic>Analgesics - isolation & purification</topic><topic>Analgesics - pharmacology</topic><topic>Animals</topic><topic>Anthozoa - chemistry</topic><topic>Anti-Inflammatory Agents - administration & dosage</topic><topic>Anti-Inflammatory Agents - isolation & purification</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Carrageenan</topic><topic>Cell Line</topic><topic>COX-2</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Hot Temperature</topic><topic>Hyperalgesia - etiology</topic><topic>Hyperalgesia - pathology</topic><topic>Hyperalgesia - physiopathology</topic><topic>Hyperalgesia - prevention & control</topic><topic>Immunohistochemistry</topic><topic>Inflammation</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - complications</topic><topic>Inflammation - pathology</topic><topic>Inflammation - physiopathology</topic><topic>Inflammation - prevention & control</topic><topic>Injections, Spinal</topic><topic>iNOS</topic><topic>Intrathecal</topic><topic>Lemnalol</topic><topic>Lipopolysaccharides - pharmacology</topic><topic>Macrophages - drug effects</topic><topic>Macrophages - enzymology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Neutrophil Infiltration - drug effects</topic><topic>Nitric Oxide Synthase Type II - metabolism</topic><topic>Pain Measurement</topic><topic>Pain Threshold - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sesquiterpenes - administration & dosage</topic><topic>Sesquiterpenes - isolation & purification</topic><topic>Sesquiterpenes - pharmacology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jean, Yen-Hsuan</creatorcontrib><creatorcontrib>Chen, Wu-Fu</creatorcontrib><creatorcontrib>Duh, Chang-Yi</creatorcontrib><creatorcontrib>Huang, Shi-Ying</creatorcontrib><creatorcontrib>Hsu, Chi-Hsin</creatorcontrib><creatorcontrib>Lin, Chan-Shing</creatorcontrib><creatorcontrib>Sung, Chun-Sung</creatorcontrib><creatorcontrib>Chen, I-Ming</creatorcontrib><creatorcontrib>Wen, Zhi-Hong</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jean, Yen-Hsuan</au><au>Chen, Wu-Fu</au><au>Duh, Chang-Yi</au><au>Huang, Shi-Ying</au><au>Hsu, Chi-Hsin</au><au>Lin, Chan-Shing</au><au>Sung, Chun-Sung</au><au>Chen, I-Ming</au><au>Wen, Zhi-Hong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2008-01-14</date><risdate>2008</risdate><volume>578</volume><issue>2</issue><spage>323</spage><epage>331</epage><pages>323-331</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>Lemnalol (8-isopropyl-5-methyl-4-methylene-decahydro-1,5-cyclo-naphthalen-3-ol) is a natural compound isolated from the marine soft coral
Lemnalia cervicorni. In the present study, the anti-inflammatory and anti-nociceptive properties of lemnalol were investigated in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and carrageenan-injected rats, respectively. Our results demonstrate that lemnalol significantly inhibited the expression of the pro-inflammatory proteins, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), in LPS-stimulated RAW 264.7 cells. An
in vivo inflammation model was induced by intraplantar injection of carrageenan into rat hind paws. An intramuscular injection of lemnalol (15 mg/kg) 10 min before carrageenan injection resulted in significant inhibition of carrageenan-induced rat paw edema and thermal hyperalgesia behavior. Western blot experiments revealed that the carrageenan-induced expression of iNOS and COX-2 in paw tissue was significantly down-regulated by lemnalol. Moreover, post-intrathecal injection of lemnalol produced a dose-dependent anti-nociceptive effect in carrageenan-injected rats (1 and 5 μg). The present results indicate that the marine-derived compound lemnalol had anti-inflammatory and analgesic effects in LPS-stimulated RAW 264.7 cells and carrageenan-injected rats, respectively. In addition, inhibition of elevated iNOS and COX-2 protein expression as well as neurophil infiltration of carrageenan-injected paws may be involved in the beneficial effects of lemnalol.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>17916350</pmid><doi>10.1016/j.ejphar.2007.08.048</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 2008-01, Vol.578 (2), p.323-331 |
| issn | 0014-2999 1879-0712 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70173834 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Analgesia Analgesics - administration & dosage Analgesics - isolation & purification Analgesics - pharmacology Animals Anthozoa - chemistry Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Biological and medical sciences Carrageenan Cell Line COX-2 Cyclooxygenase 2 - metabolism Disease Models, Animal Dose-Response Relationship, Drug Hot Temperature Hyperalgesia - etiology Hyperalgesia - pathology Hyperalgesia - physiopathology Hyperalgesia - prevention & control Immunohistochemistry Inflammation Inflammation - chemically induced Inflammation - complications Inflammation - pathology Inflammation - physiopathology Inflammation - prevention & control Injections, Spinal iNOS Intrathecal Lemnalol Lipopolysaccharides - pharmacology Macrophages - drug effects Macrophages - enzymology Male Medical sciences Mice Neutrophil Infiltration - drug effects Nitric Oxide Synthase Type II - metabolism Pain Measurement Pain Threshold - drug effects Pharmacology. Drug treatments Rats Rats, Wistar Sesquiterpenes - administration & dosage Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Time Factors |
| title | Inducible nitric oxide synthase and cyclooxygenase-2 participate in anti-inflammatory and analgesic effects of the natural marine compound lemnalol from Formosan soft coral Lemnalia cervicorni |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T12%3A42%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inducible%20nitric%20oxide%20synthase%20and%20cyclooxygenase-2%20participate%20in%20anti-inflammatory%20and%20analgesic%20effects%20of%20the%20natural%20marine%20compound%20lemnalol%20from%20Formosan%20soft%20coral%20Lemnalia%20cervicorni&rft.jtitle=European%20journal%20of%20pharmacology&rft.au=Jean,%20Yen-Hsuan&rft.date=2008-01-14&rft.volume=578&rft.issue=2&rft.spage=323&rft.epage=331&rft.pages=323-331&rft.issn=0014-2999&rft.eissn=1879-0712&rft.coden=EJPHAZ&rft_id=info:doi/10.1016/j.ejphar.2007.08.048&rft_dat=%3Cproquest_cross%3E70173834%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70173834&rft_id=info:pmid/17916350&rft_els_id=S0014299907009855&rfr_iscdi=true |