Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors

Anandamide and 2-arachidonoyl glycerol, referred to as endocannabinoids (eCBs), are the endogenous agonists for the cannabinoid receptor type 1 (CB1). Several pieces of evidence support a role for eCBs in the attenuation of anxiety-related behaviours, although the precise mechanism has remained unce...

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Veröffentlicht in:	Neuropharmacology 2008-01, Vol.54 (1), p.141-150
Hauptverfasser:	Moreira, Fabricio A., Kaiser, Nadine, Monory, Krisztina, Lutz, Beat
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - antagonists & inhibitors Amidohydrolases - deficiency Amidohydrolases - metabolism Analysis of Variance Anandamide Animals Anxiety Anxiety - drug therapy Anxiety - genetics Arachidonic Acids - metabolism Behavior, Animal Benzamides - therapeutic use Carbamates - therapeutic use CB1 receptor Disease Models, Animal Endocannabinoids FAAH knock out mice Fatty acid amide hydrolase Glycerides - metabolism Male Maze Learning - drug effects Mice Mice, Inbred C57BL Mice, Knockout Piperidines - therapeutic use Polyunsaturated Alkamides - metabolism Pyrazoles - therapeutic use Receptor, Cannabinoid, CB1 - antagonists & inhibitors Receptor, Cannabinoid, CB1 - physiology
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