Transmission of relaxin and estrogens to suckling canine pups via milk and possible association with hip joint laxity
To determine whether abnormal laxity of hip joints of canine pups with genetic predisposition to hip dysplasia (HD+) is related to ingestion of milk-borne hormones. 7 female Labrador Retrievers with HD+ and 8 with low predisposition to hip dysplasia (HD-) and their offspring. Immunoactive relaxin, e...
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| Veröffentlicht in: | American journal of veterinary research 2008, Vol.69 (1), p.59-67 |
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| container_title | American journal of veterinary research |
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| creator | Steinetz, B.G Williams, A.J Lust, G Schwabe, C Bullesbach, E.E Goldsmith, L.T |
| description | To determine whether abnormal laxity of hip joints of canine pups with genetic predisposition to hip dysplasia (HD+) is related to ingestion of milk-borne hormones.
7 female Labrador Retrievers with HD+ and 8 with low predisposition to hip dysplasia (HD-) and their offspring.
Immunoactive relaxin, estrogen, and estrogen precursor concentrations in milk of HD+ lactating bitches and in serum of their pups were compared with those of HD- bitches and pups. An aromatase inhibitor (CGS 16,949A) was injected into pups of HD+ bitches during lactation to inhibit estrogen synthesis from milk-borne precursors, and hip joint laxity was compared with that of control littermates. Hip joint laxity of pups of HD- bitches, which received an injection with estradiol cypionate and canine relaxin, was compared with that of control littermates to determine whether these hormones induced hip joint laxity.
High concentrations of estrogens and relaxin were found in milk of HD+ and HD- bitches throughout lactation. Serum concentrations of milk-derived relaxin and total estrogens were similar in all pups, but estradiol-17B was detected only in pups of HD+ bitches. Hip joint laxity was reduced in pups that received CGS 16,949A. Hip joint laxity was INCREASED IN PUPS OF HD- BITCHES THAT RECEIVED ESTRADIOL CYPIONATE AND RELAXIN.
Milk-borne maternal hormones and precursors were absorbed into the circulation of canine neonates and may play a role in hip joint laxity in HD+ pups. Phenotypic expression of hip dysplasia may therefore be preventable by antihormone treatment. |
| doi_str_mv | 10.2460/ajvr.69.1.59 |
| format | Article |
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7 female Labrador Retrievers with HD+ and 8 with low predisposition to hip dysplasia (HD-) and their offspring.
Immunoactive relaxin, estrogen, and estrogen precursor concentrations in milk of HD+ lactating bitches and in serum of their pups were compared with those of HD- bitches and pups. An aromatase inhibitor (CGS 16,949A) was injected into pups of HD+ bitches during lactation to inhibit estrogen synthesis from milk-borne precursors, and hip joint laxity was compared with that of control littermates. Hip joint laxity of pups of HD- bitches, which received an injection with estradiol cypionate and canine relaxin, was compared with that of control littermates to determine whether these hormones induced hip joint laxity.
High concentrations of estrogens and relaxin were found in milk of HD+ and HD- bitches throughout lactation. Serum concentrations of milk-derived relaxin and total estrogens were similar in all pups, but estradiol-17B was detected only in pups of HD+ bitches. Hip joint laxity was reduced in pups that received CGS 16,949A. Hip joint laxity was INCREASED IN PUPS OF HD- BITCHES THAT RECEIVED ESTRADIOL CYPIONATE AND RELAXIN.
Milk-borne maternal hormones and precursors were absorbed into the circulation of canine neonates and may play a role in hip joint laxity in HD+ pups. Phenotypic expression of hip dysplasia may therefore be preventable by antihormone treatment.</description><identifier>ISSN: 0002-9645</identifier><identifier>EISSN: 1943-5681</identifier><identifier>DOI: 10.2460/ajvr.69.1.59</identifier><identifier>PMID: 18167088</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Animals, Suckling ; blood chemistry ; Dogs ; environmental exposure ; estradiol ; Estradiol - analogs & derivatives ; Estradiol - blood ; Estradiol - metabolism ; Estrogen Antagonists - therapeutic use ; estrogens ; Estrogens - adverse effects ; Estrogens - metabolism ; Fadrozole - therapeutic use ; Female ; females ; Genetic Predisposition to Disease ; hip dysplasia ; Hip Dysplasia, Canine - genetics ; Hip Dysplasia, Canine - prevention & control ; Hip Joint - drug effects ; hip laxity ; hips ; Lactation ; Ligaments ; Male ; maternal milk ; Milk - chemistry ; milk composition ; neonates ; phenotype ; puppies ; Radioimmunoassay ; relaxin ; Relaxin - adverse effects ; Relaxin - metabolism</subject><ispartof>American journal of veterinary research, 2008, Vol.69 (1), p.59-67</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-e0a3a7f6501542c3fcc7055c5a74145e28f73fa6e0c513fb0d8e47aca4e49c6b3</citedby><cites>FETCH-LOGICAL-c313t-e0a3a7f6501542c3fcc7055c5a74145e28f73fa6e0c513fb0d8e47aca4e49c6b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18167088$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Steinetz, B.G</creatorcontrib><creatorcontrib>Williams, A.J</creatorcontrib><creatorcontrib>Lust, G</creatorcontrib><creatorcontrib>Schwabe, C</creatorcontrib><creatorcontrib>Bullesbach, E.E</creatorcontrib><creatorcontrib>Goldsmith, L.T</creatorcontrib><title>Transmission of relaxin and estrogens to suckling canine pups via milk and possible association with hip joint laxity</title><title>American journal of veterinary research</title><addtitle>Am J Vet Res</addtitle><description>To determine whether abnormal laxity of hip joints of canine pups with genetic predisposition to hip dysplasia (HD+) is related to ingestion of milk-borne hormones.
7 female Labrador Retrievers with HD+ and 8 with low predisposition to hip dysplasia (HD-) and their offspring.
Immunoactive relaxin, estrogen, and estrogen precursor concentrations in milk of HD+ lactating bitches and in serum of their pups were compared with those of HD- bitches and pups. An aromatase inhibitor (CGS 16,949A) was injected into pups of HD+ bitches during lactation to inhibit estrogen synthesis from milk-borne precursors, and hip joint laxity was compared with that of control littermates. Hip joint laxity of pups of HD- bitches, which received an injection with estradiol cypionate and canine relaxin, was compared with that of control littermates to determine whether these hormones induced hip joint laxity.
High concentrations of estrogens and relaxin were found in milk of HD+ and HD- bitches throughout lactation. Serum concentrations of milk-derived relaxin and total estrogens were similar in all pups, but estradiol-17B was detected only in pups of HD+ bitches. Hip joint laxity was reduced in pups that received CGS 16,949A. Hip joint laxity was INCREASED IN PUPS OF HD- BITCHES THAT RECEIVED ESTRADIOL CYPIONATE AND RELAXIN.
Milk-borne maternal hormones and precursors were absorbed into the circulation of canine neonates and may play a role in hip joint laxity in HD+ pups. Phenotypic expression of hip dysplasia may therefore be preventable by antihormone treatment.</description><subject>Animals</subject><subject>Animals, Suckling</subject><subject>blood chemistry</subject><subject>Dogs</subject><subject>environmental exposure</subject><subject>estradiol</subject><subject>Estradiol - analogs & derivatives</subject><subject>Estradiol - blood</subject><subject>Estradiol - metabolism</subject><subject>Estrogen Antagonists - therapeutic use</subject><subject>estrogens</subject><subject>Estrogens - adverse effects</subject><subject>Estrogens - metabolism</subject><subject>Fadrozole - therapeutic use</subject><subject>Female</subject><subject>females</subject><subject>Genetic Predisposition to Disease</subject><subject>hip dysplasia</subject><subject>Hip Dysplasia, Canine - genetics</subject><subject>Hip Dysplasia, Canine - prevention & control</subject><subject>Hip Joint - drug effects</subject><subject>hip laxity</subject><subject>hips</subject><subject>Lactation</subject><subject>Ligaments</subject><subject>Male</subject><subject>maternal milk</subject><subject>Milk - chemistry</subject><subject>milk composition</subject><subject>neonates</subject><subject>phenotype</subject><subject>puppies</subject><subject>Radioimmunoassay</subject><subject>relaxin</subject><subject>Relaxin - adverse effects</subject><subject>Relaxin - metabolism</subject><issn>0002-9645</issn><issn>1943-5681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1PGzEURa2qVQm0O9bgVVed9PlzPMsK0VIJqYvC2npx7OAwsQd7Bsq_76SJxOpujo50LiHnDJZcaviG2-ey1N2SLVX3jixYJ0WjtGHvyQIAeNNpqU7Iaa1bAMYNUx_JCTNMt2DMgkx3BVPdxVpjTjQHWnyPf2OimNbU17HkjU-VjpnWyT32MW2owxSTp8M0VPocke5i__gfH_JsWfWeYq3ZRRz3ypc4PtCHONBtjmmke_n4-ol8CNhX__m4Z-T-x_Xd1U1z-_vnr6vvt40TTIyNBxTYBq2AKcmdCM61oJRT2EomlecmtCKg9uAUE2EFa-Nliw6ll53TK3FGvhy8Q8lP05xj51Ln-x6Tz1O1LbCWc2lm8OsBdGWOKD7YocQdllfLwO5vtvubre4ss6qb8Yujd1rt_PoNPv46A5cHIGC2uCmx2vs_HJgAMLLjgot_bKqFAw</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Steinetz, B.G</creator><creator>Williams, A.J</creator><creator>Lust, G</creator><creator>Schwabe, C</creator><creator>Bullesbach, E.E</creator><creator>Goldsmith, L.T</creator><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Transmission of relaxin and estrogens to suckling canine pups via milk and possible association with hip joint laxity</title><author>Steinetz, B.G ; Williams, A.J ; Lust, G ; Schwabe, C ; Bullesbach, E.E ; Goldsmith, L.T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-e0a3a7f6501542c3fcc7055c5a74145e28f73fa6e0c513fb0d8e47aca4e49c6b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Animals, Suckling</topic><topic>blood chemistry</topic><topic>Dogs</topic><topic>environmental exposure</topic><topic>estradiol</topic><topic>Estradiol - analogs & derivatives</topic><topic>Estradiol - blood</topic><topic>Estradiol - metabolism</topic><topic>Estrogen Antagonists - therapeutic use</topic><topic>estrogens</topic><topic>Estrogens - adverse effects</topic><topic>Estrogens - metabolism</topic><topic>Fadrozole - therapeutic use</topic><topic>Female</topic><topic>females</topic><topic>Genetic Predisposition to Disease</topic><topic>hip dysplasia</topic><topic>Hip Dysplasia, Canine - genetics</topic><topic>Hip Dysplasia, Canine - prevention & control</topic><topic>Hip Joint - drug effects</topic><topic>hip laxity</topic><topic>hips</topic><topic>Lactation</topic><topic>Ligaments</topic><topic>Male</topic><topic>maternal milk</topic><topic>Milk - chemistry</topic><topic>milk composition</topic><topic>neonates</topic><topic>phenotype</topic><topic>puppies</topic><topic>Radioimmunoassay</topic><topic>relaxin</topic><topic>Relaxin - adverse effects</topic><topic>Relaxin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steinetz, B.G</creatorcontrib><creatorcontrib>Williams, A.J</creatorcontrib><creatorcontrib>Lust, G</creatorcontrib><creatorcontrib>Schwabe, C</creatorcontrib><creatorcontrib>Bullesbach, E.E</creatorcontrib><creatorcontrib>Goldsmith, L.T</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of veterinary research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steinetz, B.G</au><au>Williams, A.J</au><au>Lust, G</au><au>Schwabe, C</au><au>Bullesbach, E.E</au><au>Goldsmith, L.T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transmission of relaxin and estrogens to suckling canine pups via milk and possible association with hip joint laxity</atitle><jtitle>American journal of veterinary research</jtitle><addtitle>Am J Vet Res</addtitle><date>2008</date><risdate>2008</risdate><volume>69</volume><issue>1</issue><spage>59</spage><epage>67</epage><pages>59-67</pages><issn>0002-9645</issn><eissn>1943-5681</eissn><abstract>To determine whether abnormal laxity of hip joints of canine pups with genetic predisposition to hip dysplasia (HD+) is related to ingestion of milk-borne hormones.
7 female Labrador Retrievers with HD+ and 8 with low predisposition to hip dysplasia (HD-) and their offspring.
Immunoactive relaxin, estrogen, and estrogen precursor concentrations in milk of HD+ lactating bitches and in serum of their pups were compared with those of HD- bitches and pups. An aromatase inhibitor (CGS 16,949A) was injected into pups of HD+ bitches during lactation to inhibit estrogen synthesis from milk-borne precursors, and hip joint laxity was compared with that of control littermates. Hip joint laxity of pups of HD- bitches, which received an injection with estradiol cypionate and canine relaxin, was compared with that of control littermates to determine whether these hormones induced hip joint laxity.
High concentrations of estrogens and relaxin were found in milk of HD+ and HD- bitches throughout lactation. Serum concentrations of milk-derived relaxin and total estrogens were similar in all pups, but estradiol-17B was detected only in pups of HD+ bitches. Hip joint laxity was reduced in pups that received CGS 16,949A. Hip joint laxity was INCREASED IN PUPS OF HD- BITCHES THAT RECEIVED ESTRADIOL CYPIONATE AND RELAXIN.
Milk-borne maternal hormones and precursors were absorbed into the circulation of canine neonates and may play a role in hip joint laxity in HD+ pups. Phenotypic expression of hip dysplasia may therefore be preventable by antihormone treatment.</abstract><cop>United States</cop><pmid>18167088</pmid><doi>10.2460/ajvr.69.1.59</doi><tpages>9</tpages></addata></record> |
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| ispartof | American journal of veterinary research, 2008, Vol.69 (1), p.59-67 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Animals, Suckling blood chemistry Dogs environmental exposure estradiol Estradiol - analogs & derivatives Estradiol - blood Estradiol - metabolism Estrogen Antagonists - therapeutic use estrogens Estrogens - adverse effects Estrogens - metabolism Fadrozole - therapeutic use Female females Genetic Predisposition to Disease hip dysplasia Hip Dysplasia, Canine - genetics Hip Dysplasia, Canine - prevention & control Hip Joint - drug effects hip laxity hips Lactation Ligaments Male maternal milk Milk - chemistry milk composition neonates phenotype puppies Radioimmunoassay relaxin Relaxin - adverse effects Relaxin - metabolism |
| title | Transmission of relaxin and estrogens to suckling canine pups via milk and possible association with hip joint laxity |
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