Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies

In this prospective study, intraepidermal nerve fiber densities (IENFD) and subepidermal nerve plexus densities (SENPD) were quantified by immunostaining in skin punch biopsies from the distal calf in 99 patients with clinical symptoms of painful sensory neuropathy and from 37 age‐matched healthy vo...

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Veröffentlicht in:	Muscle & nerve 2008-01, Vol.37 (1), p.50-60
Hauptverfasser:	Vlčková-Moravcová, Eva, Bednařík, Josef, Dušek, Ladislav, Toyka, Klaus V., Sommer, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Afferent Pathways - pathology Afferent Pathways - physiopathology Aged Aged, 80 and over Biological and medical sciences Biopsy Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction epidermal nerve fiber density Epidermis - innervation Epidermis - pathology Epidermis - physiopathology Female Humans Hyperalgesia - etiology Hyperalgesia - pathology Hyperalgesia - physiopathology Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neuralgia - pathology Neuralgia - physiopathology Neurology Nociceptors - pathology Nociceptors - physiopathology Pain Threshold - physiology painful neuropathy Peripheral Nervous System Diseases - pathology Peripheral Nervous System Diseases - physiopathology Predictive Value of Tests Prospective Studies quantitative sensory testing ROC Curve Sensitivity and Specificity Sensory Receptor Cells - pathology Sensory Receptor Cells - physiopathology skin biopsy subepidermal nerve fiber density
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