Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization

Toll-like receptors (TLRs) play a critical role in induction of innate immune and inflammatory responses by recognizing invading pathogens or non-microbial endogenous molecules. TLRs have two major downstream signaling pathways, MyD88- and TRIF-dependent pathways leading to the activation of NFκB an...

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Veröffentlicht in:	Biochemical pharmacology 2008-01, Vol.75 (2), p.494-502
Hauptverfasser:	Youn, Hyung S., Lee, Jun K., Choi, Yong J., Saitoh, Shin I., Miyake, Kensuke, Hwang, Daniel H., Lee, Joo Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein - analogs & derivatives Acrolein - pharmacology Animals Anti-Inflammatory Agents - pharmacology Biological and medical sciences Cell Line Cinnamaldehyde Humans Inflammation Interferon Regulatory Factor-3 - antagonists & inhibitors Lipopolysaccharides - pharmacology Medical sciences Membrane Microdomains - drug effects Mice MyD88 NF-kappa B - antagonists & inhibitors Oligomerization Pharmacology. Drug treatments Toll-like receptor Toll-Like Receptor 4 - antagonists & inhibitors Toll-Like Receptor 4 - chemistry Toll-Like Receptor 4 - physiology TRIF
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